A novel gold nanocluster–based fluorometric biosensor for measuring prooxidant activity with a large Stokes shift

Akyüz, Esin; Şen, Furkan Burak; Bener, Mustafa; Başkan, Kevser Sözgen; Apak, Reşat

doi:10.1016/j.talanta.2019.120425

Cited by 18 publications

(13 citation statements)

References 56 publications

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“…An egg white–gold nanocluster‐based fluorescent biosensor was developed using egg white as a reducing and protecting agent to monitor the antioxidant activity induced by natural antioxidants in the Cu ++ ions of food and biological samples. The biosensor provides a simple and easy way to controlling the shelf life of food and the stability of oxidants 116 …”

Section: Application To Biomaterialsmentioning

confidence: 99%

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An insight on egg white: From most common functional food to biomaterial application

Dong

Zhang

2020

J Biomed Mater Res

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Natural egg white tis widely used as an ingredient in nutritional foods and for food processing. Due to its characteristic foaming, emulsification, adhesion, and gelation, and its heat setting, biocompatibility, and low cost, research into the application and development of egg white in biomaterials, especially medical biomaterials, have been receiving attention. The composition and characteristics of egg white protein, and the physical mixing and chemically cross‐linking of egg white with other materials used to make degradable packaging films, bioceramics, bioplastics, biomimetic films, hydrogels, 3D scaffolds, bone regeneration, biopatterning, biosensors, and so forth, are reviewed in detail in this report. The novel egg white‐based biomaterials in various forms and applications could be constructed mostly through physical treatments such as ultrasonic wave, ultraviolet, laser and other radiation or high‐temperature calcination. Furthermore, the application and prospects for the use of egg white in biomaterials is also discussed.

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Section: Application To Biomaterialsmentioning

confidence: 99%

“…The biosensor provides a simple and easy way to controlling the shelf life of food and the stability of oxidants. 116…”

Section: Biosensormentioning

confidence: 99%

An insight on egg white: From most common functional food to biomaterial application

Dong

Zhang

2020

J Biomed Mater Res

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“…The wavelength of emitted light can vary with cluster size. These superior properties make AuNCs as fluorescent probe for sensing and imaging that greatly enhance the selectivity and sensitivity and improve the imaging capability of biomarker [73,74]. The physical method for preparing AuNCs is dispersing large pieces of Au particles into nano-sized metal particles, and the obtained AuNCs have a wide particle size range and poor light stability.…”

Section: Nanoclusters (Ncs)mentioning

confidence: 99%

Noble Metal Nanostructured Materials for Chemical and Biosensing Systems

et al. 2020

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Nanomaterials with unique physical and chemical properties have attracted extensive attention of scientific research and will play an increasingly important role in the future development of science and technology. With the gradual deepening of research, noble metal nanomaterials have been applied in the fields of new energy materials, photoelectric information storage, and nano-enhanced catalysis due to their unique optical, electrical and catalytic properties. Nanostructured materials formed by noble metal elements (Au, Ag, etc.) exhibit remarkable photoelectric properties, good stability and low biotoxicity, which received extensive attention in chemical and biological sensing field and achieved significant research progress. In this paper, the research on the synthesis, modification and sensing application of the existing noble metal nanomaterials is reviewed in detail, which provides a theoretical guidance for further research on the functional properties of such nanostructured materials and their applications of other nanofields.

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“…Metal nanoclusters (NCs) are a class of extremely small and versatile nanomaterials (1–5 nm) exhibiting unique chemical and optical properties. They are composed of a few and up to 200 atoms, having a size comparable to the Fermi wavelength, and are protected by an organic molecular ligand enriching them with molecular-like properties such as large Stoke shift and tunable intrinsic photoluminescence (PL) ( Akyüz et al, 2020 ), similar to upconversion nanocrystals ( Wang et al, 2021a ; Wang et al, 2021b ). Owing to the aforementioned characteristics, NCs show potential in various applications like cell and tissue imaging ( Liu et al, 2011 ; Chen et al, 2016 ), biolabeling ( Xu et al, 2020 ), catalysis ( Li and Jin, 2013 ), molecular identification ( Zhang et al, 2018 ), ion detection ( Ding et al, 2014 ; Hada et al, 2021c ), etc.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Photoluminescence of Solid-State Gold Nanoclusters: Towards Fluorescence Lifetime Imaging of Tissue-Like Phantoms Under Two-Photon Near-Infrared Excitation

2021

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Gold nanoclusters (AuNCs) have attracted extensive attention as light-emissive materials with unique advantages such as high photostability, large Stoke shifts and low toxicity. However, a better understanding of their solid-state photoluminescence properties is still needed. Herein, we investigated for the first time the intrinsic photoluminescence properties of lyophilized bovine serum albumin stabilized AuNCs (BSA-AuNCs) via fluorescence lifetime imaging microscopy (FLIM) studies performed under both one and two photon excitations (OPE and TPE) on individual microflakes, combined with fluorescence spectroscopic investigations. Both in solution and solid-state, the synthesized BSA-AuNCs exhibit photoluminescence in the first biological window with an absolute quantum yield of 6% and high photostability under continuous irradiation. Moreover, under both OPE and TPE conditions, solid BSA-AuNCs samples exhibited a low degree of photobleaching, while FLIM assays prove the homogeneous distribution of the photoluminescence signal inside the microflakes. Finally, we demonstrate the ability of BSA-AuNCs to perform as reliable bright and photostable contrast agents for the visualization of cancer tissue mimicking agarose-phantoms using FLIM approach under non-invasive TPE. Therefore, our results emphasize the great potential of the as synthesized BSA-AuNCs for ex vivo and in vivo non-invasive NIR imaging applications.

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A novel gold nanocluster–based fluorometric biosensor for measuring prooxidant activity with a large Stokes shift

Cited by 18 publications

References 56 publications

An insight on egg white: From most common functional food to biomaterial application

An insight on egg white: From most common functional food to biomaterial application

Noble Metal Nanostructured Materials for Chemical and Biosensing Systems

Intrinsic Photoluminescence of Solid-State Gold Nanoclusters: Towards Fluorescence Lifetime Imaging of Tissue-Like Phantoms Under Two-Photon Near-Infrared Excitation

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