A novel glass ionomer cement containing MgCO3 apatite induced the increased proliferation and differentiation of human pulp cells in vitro

Laiteerapong, Arunee; Lochaiwatana, Yossakit; Hirata, Isao; Okazaki, Masanori; Mori, Kensaku; Murakami, Shinya; Poolthong, Suchit

doi:10.4012/dmj.2012-096

Cited by 4 publications

(4 citation statements)

References 22 publications

(24 reference statements)

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“…Dental pulp cells cultured in vitro are able to form mineralization nodules at the site where cellular nodules exhibit multilayer growth and can aggregate under the effect of mineralization induction solution (Laiteerapong et al, 2012). Some studies have discovered that these mineralized nodules are primarily comprised of a dentin-like mineralized matrix, which has the characteristics of dentin (Jiang et al, 2012;Jin et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

2015

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ABSTRACT. We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferation. Alizarin red staining was used to observe the formation of mineralized nodules after cell mineralization and induction for 10 and 20 days under different culture conditions, and the areas of the mineralized nodules formed 20 days after induction were computed. The addition of 1, 10, and 100 mL/L WPLTs or PRP significantly promoted rat dental pulp cell proliferation (P < 0.05) whereas 500 mL/L WPLTs or PRP had no significant effect (P > 0.05). Under the same concentrations, no significant differences on cell proliferation were observed between WPLT and PRP treatments (P > 0.05 in all groups). After 10 days mineralization and culture, the 100 and 500 mL/L WPLT and PRP group positive nodule rates were significantly higher than those of the low concentration and the control groups (P < 0.05). After 20 days, the areas of the mineralized nodules formed in the 100 and 500 mL/L WPLT and 9487 Effects of WPLTs and PRP on rat dental pulp cells ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9486-9496 (2015) PRP groups were significantly larger than those in the control group (P < 0.05). These results demonstrate that both WPLTs and PRP are equally able to significantly promote the proliferation and calcification of rat dental pulp cells under a certain range of concentrations.

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Section: Discussionmentioning

confidence: 99%

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

2015

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“…Mg scaffolds induce cell proliferation, migration, and osteogenic differentiation of human dental pulp cells and participate in the process of pulp repair [ 113 , 114 , 115 ].…”

Section: Mg-based Materials For Soft Tissue Regenerationmentioning

confidence: 99%

Applications of Biodegradable Magnesium-Based Materials in Reconstructive Oral and Maxillofacial Surgery: A Review

et al. 2022

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Reconstruction of defects in the maxillofacial region following traumatic injuries, craniofacial deformities, defects from tumor removal, or infections in the maxillofacial area represents a major challenge for surgeons. Various materials have been studied for the reconstruction of defects in the maxillofacial area. Biodegradable metals have been widely researched due to their excellent biological properties. Magnesium (Mg) and Mg-based materials have been extensively studied for tissue regeneration procedures due to biodegradability, mechanical characteristics, osteogenic capacity, biocompatibility, and antibacterial properties. The aim of this review was to analyze and discuss the applications of Mg and Mg-based materials in reconstructive oral and maxillofacial surgery in the fields of guided bone regeneration, dental implantology, fixation of facial bone fractures and soft tissue regeneration.

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“…Mg ions enter human dental pulp cells (hDPSCs) via ion channel TRPM7, and are involved in cell proliferation, migration, and osteogenic differentiation, and participate in the process of pulp repair [ 179 ]. The addition of 2.5% Mg carbonate apatite to a glass ionomer cement promoted the proliferation and mineralization of hDPSCs, which showed a potential for dentin regeneration and repair [ 180 ]. Kong et al.…”

Section: Mg-based Bms For Oral and Maxillofacial Applicationmentioning

confidence: 99%

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

Xia

Yang

Zheng

et al. 2021

Bioactive Materials

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The oral and maxillofacial regions have complex anatomical structures and different tissue types, which have vital health and aesthetic functions. Biodegradable metals (BMs) is a promising bioactive materials to treat oral and maxillofacial diseases. This review summarizes the research status and future research directions of BMs for oral and maxillofacial applications. Mg-based BMs and Zn-based BMs for bone fracture fixation systems, and guided bone regeneration (GBR) membranes, are discussed in detail. Zn-based BMs with a moderate degradation rate and superior mechanical properties for GBR membranes show great potential for clinical translation. Fe-based BMs have a relatively low degradation rate and insoluble degradation products, which greatly limit their application and clinical translation. Furthermore, we proposed potential future research directions for BMs in the oral and maxillofacial regions, including 3D printed BM bone scaffolds, surface modification for BMs GBR membranes, and BMs containing hydrogels for cartilage regeneration, soft tissue regeneration, and nerve regeneration. Taken together, the progress made in the development of BMs in oral and maxillofacial regions has laid a foundation for further clinical translation.

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A novel glass ionomer cement containing MgCO3 apatite induced the increased proliferation and differentiation of human pulp cells in vitro

Cited by 4 publications

References 22 publications

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells

Applications of Biodegradable Magnesium-Based Materials in Reconstructive Oral and Maxillofacial Surgery: A Review

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

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