A novel genetic fluorescent reporter to visualize mitochondrial nucleoids
Jingti Deng,
Lucy Swift,
Fatemeh Shahhosseini
et al.
Abstract:Mitochondria have their own genome (mtDNA), which is present in hundreds of copies per cell and organized into nucleoid structures that are distributed throughout the dynamic mitochondrial network. Beyond encoding essential protein subunits for oxidative phosphorylation, mtDNA can also serve as a signalling molecule when it is present into the cytosol. Despite the importance of this genome, there are still many unknowns with respect to its regulation. To study mtDNA dynamics in living cells, we have developed … Show more
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