A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells

Chang, Glenn T.G.; Steenbeek, Martine; Schippers, Esther; Blok, Leen J.; Weerden, W.M. Van; Alewijk, Dirk C.J.G. van; Eussen, Bert; Steenbrugge, G.J. van; Brinkmann, Albert O.

doi:10.1016/s0959-8049(01)00259-3

Cited by 7 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A higher degree of resemblance exists between the endometrial samples (tissue and cell-line samples), than between the endometrial samples and the breast cancer cell-line, implicating a basic endometrial gene-expression fingerprint. As tumour behaviour is thought to be driven by genetic alterations, it is plausible that clinical behaviour of carcinomas can be reflected in their specific gene-expression fingerprints (Blok et al, 1995;Chang et al, 1997) Figure 2, could be used to establish the degree of similarity between the tumour samples. Using the cDNA expression array to reveal degrees of similarity between uncharacterized tumour samples of interest and tumour samples of known clinical behaviour, could have great potential value in the diagnosis and prognosis of endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique: assessment of an analysis method

et al. 2000

View full text Add to dashboard Cite

SummaryThe recently developed cDNA expression array technique can be used to generate gene-expression fingerprints of tumour specimens. To gain insight into molecular mechanisms involved in the development and progression of cancer, this cDNA expression array technique could be a useful tool, however, no established methods for interpreting the results are yet available. We used the Atlas cancer cDNA expression array (Clontech, USA) for analysing total RNA isolated from four human endometrial carcinoma samples (two cell-lines and two tissue samples), one benign endometrial tissue sample and a human breast cancer cell-line, in order to develop a method for analysing the array data. The obtained gene-expression profiles were highly reproducible. XY-scatterplots and regression analysis of the logarithmic transformed data provided a practical method to analyse the data without the need of preceding normalization. Three genes (Decorin, TIMP3 and Cyclin D1) were identified to be differentially expressed between the benign endometrial tissue sample and the endometrial carcinoma samples (tissue and cell-lines). These three genes may potentially be involved in cancer progression. A higher degree of similarity in geneexpression profile was found between the endometrial samples (tissue and cell-lines) than between the endometrial samples and the breast cancer cell-line, which is indicative for an endometrial tissue-specific gene-expression profile.

show abstract

Section: Discussionmentioning

confidence: 99%

Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique: assessment of an analysis method

et al. 2000

View full text Add to dashboard Cite

show abstract

“…The GC109 (2p24) product, which is downregulated in androgen-independent prostate cancer, contains a leucine zipper and a ret-finger-protein-like domain (Ref 123),. The best-known alterations of chromosome 1 in prostate cancer are mutations in hereditary prostate cancer loci that were identified in several linkage analyses.…”

mentioning

confidence: 99%

Genetic factors underlying prostate cancer

Luo

2003

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Prostate cancer is one of the leading causes of cancer-related death in the USA. In the past decade, tremendous progress has been made in the identification and understanding of the genetic factors related to prostate cancer development. Unlike many other types of cancers, only a small fraction of prostate cancer cases are aggressive and life-threatening. The factors related to prostate cancer development and progression appear complex and diverse. This review summarises some of the important findings in the areas of genome and gene expression abnormalities in prostate cancer, and aims to provide a comprehensive view of new developments in these areas.

show abstract

“…Nesse sistema, os tumores são classificados em 5 graus, denominando-se grau 1 as lesões mais diferenciadas e grau 5 as mais indiferenciadas. Como os adenocarcinomas da próstata apresentam mais de um padrão histológico, o diagnóstico final na escala de Gleason é dado pela soma dos graus do padrão primário (predominante) e do padrão secundário (segunda maior área representada) McNEAL, 1992;ISAACS, 1997; CHANG et al, 2001; INTITUTO NACIONAL DO CÂNCER, INCA, 2004). Outrossim, é a segunda causa de morte em homens (COFFEY, 1993;ALBRIGHT;EELES, 1995;GIMBA;BARCINSKI, 2003) depois do câncer de pulmão WEIR et al, 2003).…”

Section: O Sistema De Graduação Histológico Mais Utilizado é O Proposunclassified

Análise molecular de polimorfismos e expressão gênica do fator β1 de transformação do crescimento (TGF-β1) no câncer de próstata.

Faria¹

View full text Add to dashboard Cite

A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells

Cited by 7 publications

References 18 publications

Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique: assessment of an analysis method

Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique: assessment of an analysis method

Genetic factors underlying prostate cancer

Análise molecular de polimorfismos e expressão gênica do fator β1 de transformação do crescimento (TGF-β1) no câncer de próstata.

Contact Info

Product

Resources

About