A Novel Gastrin-Binding Protein in the Human Eosinophil

Praissman, Melvin; Fox, Robin L.; Walden, Mae; Praissman, Laura A.; Kromholz, Noah W.; Zahra, Tasneem; Abrar, Naim; Feffer, Stephen E.; Grant, Michelle

doi:10.1006/bbrc.1997.8025

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…This is how a particular long-suspected new gastrin binding type (Bold et al, 1994) was recently evidenced, in which the G-gly binding was not subject to inhibition by gastrin or the inhibitors of the CCK A or CCK B receptors (Seva et al, 1994). Additional CCK/gastrin re- ceptor types are also suspected Baldwin, 1994;Singh et al, 1995;Praissman et al, 1998). We are carrying out investigations to ascertain whether these various receptor types could be involved in the gastrin-mediated effects in astrocytic tumors.…”

Section: Discussionmentioning

confidence: 91%

“…It has also been shown that gastrin is able to significantly inhibit motility via an increase in the level of cell adhesion to the substrate in several cell types of the immune system (de la Fuente et al, 1995Fuente et al, , 1996Fuente et al, , 1997Carrasco et al, 1997a,b). A new type of gastrinbinding protein is even suspected in eosinophils (Praissman et al, 1998). For reasons which still remain to be elucidated, all the authors who have succeeded in demonstrating a significant gastrin-and/or CCK-mediated effect of cell motility have observed such an effect in a very narrow dose range, i.e., between 10 Ϫ10 /10 Ϫ9 and 10…”

Section: Discussionmentioning

confidence: 99%

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Gastrin inhibits motility, decreases cell death levels and increases proliferation in human glioblastoma cell lines

et al. 1998

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Gastrin inhibits motility, decreases cell death levels and increases proliferation in human glioblastoma cell lines

et al. 1998

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“…First, matrix metalloproteinase-1 has been identified in eosinophils (26) and could theoretically perpetuate ulceration or lead to perforation by breaking down the extracellular matrix of the bowel wall. Additionally, human eosinophils have been shown to contain a gastrin binding protein (most likely major basic protein) (27) with an interaction with gastrin that may regulate gastric acid secretion.…”

Section: Figmentioning

confidence: 99%

Helicobacter pylori and Meckel's Diverticula

Finn,

Christie

2001

J. pediatr. gastroenterol. nutr.

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BackgroundHelicobacter pylori is known to infect only gastric mucosa and is strongly associated with gastroduodenal ulceration. The authors studied whether H. pylori colonizes the gastric mucosa of Meckel's diverticula, and determined its relationship to “gastritis” and bleeding.MethodsA 10‐year retrospective review identified 45 children with Meckel's diverticulum. Hematoxylin–eosin and Diff‐Quik stains were used to assess the presence and severity of gastritis, and to highlight organisms in the resected diverticula. Cases with organisms were then studied with antibodies specific for H. pylori using immunoperoxidase methods.ResultsTwenty‐eight children, 7 months to 12.6 years of age, had lower gastrointestinal hemorrhage caused by Meckel's diverticulum and had positive radionuclide scans. All had acid‐secreting mucosa in their diverticula, and ulceration. “Chronic gastritis” and eosinophilia were constant findings; “acute gastritis” was present in four patients. Twenty specimens exhibited lymphoid follicles in the gastric mucosa. Seventeen patients with Meckel's diverticula (age range, 1 month–14.7 years) who presented with acute abdominal pain associated with intussusception were used for comparison. Acid‐secreting gastric mucosa was seen in four patients. H. pylori was identified in only one of the 45 patients; this patient had ulceration and moderate “acute gastritis.”ConclusionsH. pylori does not colonize a substantial number of children who have ulcerated and bleeding Meckel's diverticulum in the presence of acid‐secreting mucosa. Although H. pylori is a notable cause of ulceration, the authors confirm that ulceration is possible in its absence, and alternative mechanisms of ulceration are important. The presence of lymphoid follicles in Meckel's diverticula, unlike gastric biopsies, is not associated with H. pylori.

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Helicobacter pylori and Meckel's Diverticula

Finn

Christie

2001

Journal of Pediatric Gastroenterology and Nutrition

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H. pylori does not colonize a substantial number of children who have ulcerated and bleeding Meckel's diverticulum in the presence of acid-secreting mucosa. Although H. pylori is a notable cause of ulceration, the authors confirm that ulceration is possible in its absence, and alternative mechanisms of ulceration are important. The presence of lymphoid follicles in Meckel's diverticula, unlike gastric biopsies, is not associated with H. pylori.

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A Novel Gastrin-Binding Protein in the Human Eosinophil

Cited by 4 publications

References 25 publications

Gastrin inhibits motility, decreases cell death levels and increases proliferation in human glioblastoma cell lines

Gastrin inhibits motility, decreases cell death levels and increases proliferation in human glioblastoma cell lines

Helicobacter pylori and Meckel's Diverticula

Helicobacter pylori and Meckel's Diverticula

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