A Novel G-Protein-Coupled Receptor Gene Expressed in Striatum

Mizushima, Koichi; Miyamoto, Yasuhide; Tsukahara, Fujiko; Hirai, Momoki; Sakaki, Yoshiyuki; Ito, Takashi

doi:10.1006/geno.2000.6340

Cited by 79 publications

(198 citation statements)

References 27 publications

Supporting

Mentioning

192

Contrasting

Order By: Relevance

“…GPR88 is an orphan GPCR of the family A, which shows highest homology to 5HT 1D -receptor and the beta 3 adrenergic receptor, respectively. GPR88 was recently described to be selectively expressed in the striatum; 105 however, its mRNA is also present in cerebral cortex, nucleus accumbens, Amy, Hippo, Hypo, thalamus, and LC (Allen Brain Atlas, GNF Atlas and our own unpublished data). Several lines of evidence suggest that GPR88 mRNA is regulated in a variety of psychiatric conditions including bipolar disorder and major depression.…”

Section: Number Of Transcripts Affected By Single and Multiple Treatmmentioning

confidence: 86%

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

et al. 2006

View full text Add to dashboard Cite

The significant proportion of depressed patients that are resistant to monoaminergic drug therapy and the slow onset of therapeutic effects of the selective serotonin reuptake inhibitors (SSRIs)/serotonin/noradrenaline reuptake inhibitors (SNRIs) are two major reasons for the sustained search for new antidepressants. In an attempt to identify common underlying mechanisms for fast-and slow-acting antidepressant modalities, we have examined the transcriptional changes in seven different brain regions of the rat brain induced by three clinically effective antidepressant treatments: electro convulsive therapy (ECT), sleep deprivation (SD), and fluoxetine (FLX), the most commonly used slow-onset antidepressant. Each of these antidepressant treatments was applied with the same regimen known to have clinical efficacy: 2 days of ECT (four sessions per day), 24 h of SD, and 14 days of daily treatment of FLX, respectively. Transcriptional changes were evaluated on RNA extracted from seven different brain regions using the Affymetrix rat genome microarray 230 2.0. The gene chip data were validated using in situ hybridization or autoradiography for selected genes. The major findings of the study are:1. The transcriptional changes induced by SD, ECT and SSRI display a regionally specific distribution distinct to each treatment. 2. The fast-onset, short-lived antidepressant treatments ECT and SD evoked transcriptional changes primarily in the catecholaminergic system, whereas the slow-onset antidepressant FLX treatment evoked transcriptional changes in the serotonergic system. 3. ECT and SD affect in a similar manner the same brain regions, primarily the locus coeruleus, whereas the effects of FLX were primarily in the dorsal raphe and hypothalamus, suggesting that both different regions and pathways account for fast onset but short lasting effects as compared to slow-onset but long-lasting effects. However, the similarity between effects of ECT and SD is somewhat confounded by the fact that the two treatments appear to regulate a number of transcripts in an opposite manner. 4. Multiple transcripts (e.g. brain-derived neurotrophic factor (BDNF), serum/glucocorticoidregulated kinase (Sgk1)), whose level was reported to be affected by antidepressants or behavioral manipulations, were also found to be regulated by the treatments used in the present study. Several novel findings of transcriptional regulation upon one, two or all three treatments were made, for the latter we highlight homer, erg2, HSP27, the proto oncogene ret, sulfotransferase family 1A (Sult1a1), glycerol 3-phosphate dehydrogenase (GPD3), the orphan receptor G protein-coupled receptor 88 (GPR88) and a large number of expressed sequence tags (ESTs). 5. Transcripts encoding proteins involved in synaptic plasticity in the hippocampus were strongly affected by ECT and SD, but not by FLX.The novel transcripts, concomitantly regulated by several antidepressant treatments, may represent novel targets for fast onset, long-duration antidepressants.

show abstract

Section: Number Of Transcripts Affected By Single and Multiple Treatmmentioning

confidence: 86%

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

et al. 2006

View full text Add to dashboard Cite

show abstract

“…CNS expression is particularly robust in striatum, paralleling that of the dopamine D2 receptor 1 and suggesting that the receptor may play a role in regulating dopaminergic activity. Consistent with this hypothesis, genetically-modified mice that lack GPR88 expression exhibit disrupted prepulse inhibition of startle (PPI) and increased sensitivity to apomorphine-induced climbing and stereotypy (AICS) and amphetamine-stimulated locomotor activity.…”

mentioning

confidence: 98%

Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88

Dzierba

Dasgupta

et al. 2015

Bioorganic & Medicinal Chemistry Letters

View full text Add to dashboard Cite

“…Comparison of expression patterns between different brain structures was first undertaken on a modest number of genes by using subtractive hybridization and differential mRNA display [6][7][8]. In contrast, global approaches currently allow large-scale comparative analyses, and have been used mainly to detect molecular alterations in neurodegenerative and neuropsychiatric conditions [9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiling of Rat Cerebral Cortex Development Using cDNA Microarrays

Lee

2008

Neurochem Res

View full text Add to dashboard Cite

A large amount of genetic information is devoted to brain development. In this study, the cortical development in rats at eight developmental time points (four embryonic [E15, E16, E18, E20] and four postnatal [P0, P7, P14, P21]) was studied using a rat brain 10K cDNA microarray. Significant differential expression was observed in 467 of the 9,805 genes represented on the microarray. Two major Gene Ontology classes-cell differentiation and cell-cell signaling-were found to be important for cortical development. Genes for ribosomal proteins, heterogeneous nuclear ribonucleoproteins, and tubulin proteins were up-regulated in the embryonic stage, coincidently with extensive proliferation of neural precursor cells as the major component of the cerebral cortex. Genes related to neurogenesis, including neurite regeneration, neuron development, and synaptic transmission, were more active in adulthood, when the cerebral cortex reached maturity. The many developmentally modulated genes identified by this approach will facilitate further studies of cortical functions.

show abstract

A Novel G-Protein-Coupled Receptor Gene Expressed in Striatum

Cited by 79 publications

References 27 publications

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88

Gene Expression Profiling of Rat Cerebral Cortex Development Using cDNA Microarrays

Contact Info

Product

Resources

About