A novel function of capsaicin-sensitive TRPV1 channels: Involvement in cell migration

Waning, J; Vriens, Joris; Owsianik, Grzegorz; Stüwe, Laura; Mally, Sabine; Fabian, Anke; Frippiat, Christophe; Nilius, Bernd; Schwab, Albrecht

doi:10.1016/j.ceca.2006.11.005

Cited by 137 publications

(107 citation statements)

References 58 publications

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“…In this context, previous studies provided evidence for tonic activation of NK-1 receptors, through NK-1 receptor antagonist SR14033 administration, which blocked the second phase of the orofacial formalin test in rat (Henry et al, 1999;Luccarini et al, 2003). Waning et al (2007) demonstrated that capsaicin-sensitive transient receptor potential vaniloid 1 (TRPV1) is one of the Ca +2 influx channels involved in cell migration, which plays an important role in pain transduction. Moreover, Honda et al (2008) suggest that TRPV1 receptor mechanisms in rat facial skin influence nociceptive responses to noxious cutaneous thermal and mechanical stimuli by inducing neuroplastic changes in subnucleus caudalis (Vc) and C1-C2 neurons.…”

Section: Discussionmentioning

confidence: 95%

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Venâncio¹,

Marchioro²,

Estavam³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 μM)-and capsaicin (2.5 µg)-induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.

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Section: Discussionmentioning

confidence: 95%

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Venâncio¹,

Marchioro²,

Estavam³

et al. 2011

Rev. bras. farmacogn.

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“…However, with respect to TRPV1 channel diverging results have been reported, suggesting that its role in malignant motility and invasion may be cancer cell-specific. Indeed, activation of the TRPV1 channel was shown to promote migration of human hepatoblastoma cells in response to hepatocyte growth factor treatment [74]. On the other hand, in urothelial cancer TRPV1 downregulation rather than enhancement was found to correlate with more aggressive and invasive tumour phenotype suggesting that such downregulation may present an independent negative prognostic factor for bladder cancer patients [81].…”

Section: Ca 2þ Remodelling In Promotion Cell Migration and Metastasismentioning

confidence: 99%

“…The following Ca 2þ permeable channels have been implicated in the enhanced migration of various types of cancer cells (figure 3): TRPC1 [64], TRPM7 [65 -71], TRPM8 [43,72,73], TRPV1 [74], TRPV2 [75], TRPV6 [40], STIM1 and ORAI1 SOC constituents [13,[76][77][78][79], some types of VGCCs [35,80]. Owing to the presence of mechanical stimulusdependent and Mg-ATP-dependent modes of activation TRPM7 was especially implicated in providing spatially restricted Ca 2þ entry in response to local membrane stretch in front of migrating cells [66,69] as well as promoting m-calpain-mediated disassembly of peripheral adhesions under decreased intracellular Mg-ATP levels [65] typically found in hypoxic tumour conditions.…”

Section: Ca 2þ Remodelling In Promotion Cell Migration and Metastasismentioning

confidence: 99%

Remodelling of Ca²⁺transport in cancer: how it contributes to cancer hallmarks?

Prevarskaya

Ouadid-Ahidouch²,

Skryma

et al. 2014

Phil. Trans. R. Soc. B

223

195

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Cancer involves defects in the mechanisms underlying cell proliferation, death and migration. Calcium ions are central to these phenomena, serving as major signalling agents with spatial localization, magnitude and temporal characteristics of calcium signals ultimately determining cell's fate. Cellular Ca 2+ signalling is determined by the concerted action of a molecular Ca 2+ -handling toolkit which includes: active energy-dependent Ca 2+ transporters, Ca 2+ -permeable ion channels, Ca 2+ -binding and storage proteins, Ca 2+ -dependent effectors. In cancer, because of mutations, aberrant expression, regulation and/or subcellular targeting of Ca 2+ -handling/transport protein(s) normal relationships among extracellular, cytosolic, endoplasmic reticulum and mitochondrial Ca 2+ concentrations or spatio-temporal patterns of Ca 2+ signalling become distorted. This causes deregulation of Ca 2+ -dependent effectors that control signalling pathways determining cell's behaviour in a way to promote pathophysiological cancer hallmarks such as enhanced proliferation, survival and invasion. Despite the progress in our understanding of Ca 2+ homeostasis remodelling in cancer cells as well as in identification of the key Ca 2+ -transport molecules promoting certain malignant phenotypes, there is still a lot of work to be done to transform fundamental findings and concepts into new Ca 2+ transport-targeting tools for cancer diagnosis and treatment.

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“…Interesting candidates are members of the transient receptor potential (TRP) family of cation channels. We have recently shown that activation of the TRP vanilloid 1 channel (TRPVA) accelerates migration of human hepatoblastoma cells [44]. Here, we study the effect of TRP cation channel subfamily C member 1 (TRPC1) on migration of transformed renal epithelial (Madin-Darby canine kidney-focus (MDCK-F)) cells.…”

Section: Introductionmentioning

confidence: 99%

TRPC1 channels regulate directionality of migrating cells

Fabian

Fortmann

Dieterich

et al. 2008

Pflugers Arch - Eur J Physiol

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Cell migration depends on the generation of structural asymmetry and on different steps: protrusion and adhesion at the front and traction and detachment at the rear part of the cell. The activity of Ca 2+ channels coordinate these steps by arranging intracellular Ca 2+ signals along the axis of movement. Here, we investigated the role of the putative mechanosensitive canonical transient receptor potential channel 1 (TRPC1) in cell migration. We analyzed its function in transformed renal epithelial (Madin-Darby canine kidney-focus) cells with variation of TRPC1 expression. As shown by time lapse video microscopy, TRPC1 knockdown cells have partially lost their polarity and the ability to persistently migrate into a given direction. This failure is linked to the suppression of a local Ca 2+ gradient at the front of migrating TRPC1 knockdown cells, whereas TRPC1 overexpression leads to steeper Ca 2+ gradients. We propose that the Ca 2+ signaling events regulated by TRPC1 within the lamellipodium determine polarity and directed cell migration.

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A novel function of capsaicin-sensitive TRPV1 channels: Involvement in cell migration

Cited by 137 publications

References 58 publications

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Remodelling of Ca²⁺transport in cancer: how it contributes to cancer hallmarks?

TRPC1 channels regulate directionality of migrating cells

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A novel function of capsaicin-sensitive TRPV1 channels: Involvement in cell migration

Cited by 137 publications

References 58 publications

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Remodelling of Ca2+transport in cancer: how it contributes to cancer hallmarks?

TRPC1 channels regulate directionality of migrating cells

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Remodelling of Ca²⁺transport in cancer: how it contributes to cancer hallmarks?