1996
DOI: 10.1073/pnas.93.13.6635
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A novel function for Myc: inhibition of C/EBP-dependent gene activation.

Abstract: We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present evidence that Myc downregulates these genes by inhibiting the function of C/EBP transcription factors. Detailed examination of the inhibitory mechanism shows that amino-terminal sequences of v-Myc… Show more

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Cited by 58 publications
(70 citation statements)
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“…The analyses clearly revealed association of p110 gagÀmyc with C/EBP proteins in MC29-transformed cells (Figure 5f), confirming and extending previous circumstantial evidence for possible direct interaction between these proteins (Mink et al, 1996;Hartl et al, 2003).…”
Section: Ws5 a Direct Transcriptional Target Of Myc F Reiter Et Alsupporting
confidence: 87%
See 1 more Smart Citation
“…The analyses clearly revealed association of p110 gagÀmyc with C/EBP proteins in MC29-transformed cells (Figure 5f), confirming and extending previous circumstantial evidence for possible direct interaction between these proteins (Mink et al, 1996;Hartl et al, 2003).…”
Section: Ws5 a Direct Transcriptional Target Of Myc F Reiter Et Alsupporting
confidence: 87%
“…C/EBPa is a multifunctional transcription factor that is involved in the specification of the differentiated phenotype through gene activation, but was recently also implicated in the acceleration of cell proliferation and activation of metastasis related genes (Heckman et al, 2003;Liu et al, 2004;Wang and Timchenko, 2005). Notably, functional interactions of Myc with the C/EBPb protein have been reported previously (Mink et al, 1996;Hartl et al, 2003).…”
Section: Ws5 a Direct Transcriptional Target Of Myc F Reiter Et Almentioning
confidence: 99%
“…Recently, transient transfection reporter assays demonstrate that in 3T3-L1 cells, ectopic Myc expression can abrogate the C/EBPa mediated activation of gadd45 transcription associated with adipocyte di erentiation (Constance et al, 1996). In addition, Mink et al show ectopic v-Myc can suppress the expression of myelomonocytic speci®c genes by inhibiting both the expression and the function of C/ EBPa transcription factors (Mink et al, 1996) C/EBPa is predominantly expressed in di erentiated cells (Birkenmeier et al, 1989), hence the role of C/EBPa in the G0/G1-associated up-regulation, or Mycmediated repression of gadd45 in cycling cells, remains unclear. Indeed, Myc may repress gadd45 directly by interacting with components of the core transcription complex, indirectly in an enhancer-dependent manner or by a yet unknown mechanism of action.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, oncogenic transcription factors may directly or indirectly in¯uence the activity of other transcriptional regulators and thereby amplify functional alterations in the complex transcription factor network leading to a profound disturbance of cellular proliferation control (Miao and Curran, 1994;Mink et al, 1996). The deregulation of several AP-1 responsive genes, like those encoding the metalloproteases stromelysin or type I collagenase, Fos-related antigen Fra-1, or ornithine decarboxylase, has been implicated in the c-fos-dependent malignant progression of skin tumors (Saez et al, 1995) or the fos-induced transformation of rat ®broblasts (Miao and Curran, 1994).…”
Section: Target Genes and Cell Transformationmentioning
confidence: 99%