Abstract:43 44 A novel bio-active scaffold for enhancing wounded meniscus healing has been developed by 45 combination of High mobility group box 1 protein (HMGB1) and kartogenin (KGN) with 46 alginate gel. The properties of the bio-active scaffold were also investigated using an in vitro cell 47 culture model and in vivo rat wounded meniscus healing model. This HMGB1-KGN-containing 48 bioactive scaffold released HMGB1 and KGN into wound area and kept high concentrations of 49 HMGB1 and KGN in the system for more than … Show more
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