A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial

Nasimi, Nasrin; Sohrabi, Zahra; Dabbaghmanesh, Mohammad Hossein; Eskandari, Mohammad Hadi; Bedeltavana, Alireza; Famouri, Mandana; Talezadeh, Pedram

doi:10.1016/j.jamda.2020.08.035

Cited by 21 publications

(51 citation statements)

References 43 publications

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“…Although we intended to include both RCTs and quasi-experimental studies, the final 11 included studies were all RCTs ( Table 1 ). These RCTs were conducted from 2010 to 2021 in Greece ( Tsekoura et al, 2018 ), Turkey ( Sen et al, 2021 ), Japan ( Maruya et al, 2016 ), mainland China (two RCTs) ( Bo et al, 2019 ; Li et al, 2021 ), Taiwan (two RCTs) ( Chang et al, 2021 ; Lin et al, 2021 ), Finland ( Björkman et al, 2020 ), Iran ( Nasimi et al, 2021 ), Mexico ( Alemán-Mateo et al, 2012 ) and eight countries across Europe and North America ( Cramer et al, 2016 ). Eight RCTs had two arms, two RCTs had three arms, and the remaining RCT had four arms.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 1136 participants (aged 60–89 years) were included in the 11 RCTs, ranging from 40 to 328 in each individual study. All RCTs included older people of both sexes with sarcopenia, and the age criteria were older than 65 years in four RCTs ( Chang et al, 2021 ; Cramer et al, 2016 ; Lin et al, 2021 ; Nasimi et al, 2021 ), older than 60 years in four RCTs ( Alemán-Mateo et al, 2012 ; Li et al, 2021 ; Maruya et al, 2016 ; Tsekoura et al, 2018 ), older than 75 years in one RCT ( Björkman et al, 2020 ), 65–80 years in one RCT ( Sen et al, 2021 ) and 60–80 years in one RCT ( Bo et al, 2019 ) ( Table 1 ). The diagnostic criteria for sarcopenia varied in each study (Appendix Table 1) and were classified into three types: AWGS 2014 sarcopenia diagnostic criteria (used in five RCTs), EWGSOP 2010 criteria (used in three RCTs), and other criteria (used in three RCTs).…”

Section: Resultsmentioning

confidence: 99%

“…Details of the home-based non-pharmacological interventions for sarcopenia are provided in Appendix Table 2 according to the TIDieR checklist ( Hoffmann et al, 2016 ). The interventions were categorized into three types: home-based exercise intervention ( Chang et al, 2021 ; Maruya et al, 2016 ; Sen et al, 2021 ; Tsekoura et al, 2018 ), home-based nutritional intervention ( Alemán-Mateo et al, 2012 ; Björkman et al, 2020 ; Bo et al, 2019 ; Cramer et al, 2016 ; Lin et al, 2021 ; Nasimi et al, 2021 ), and home-based combined exercise and nutritional intervention ( Li et al, 2021 ). Although we found some studies of mind-body interventions for sarcopenia in our preliminary search, the limited studies did not meet our inclusion criteria ( Pandya, 2019 ; Zhu et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Health maintenance through home-based interventions for community-dwelling older people with sarcopenia during and after the COVID-19 pandemic: A systematic review and meta-analysis

Kor

Sui

et al. 2023

Experimental Gerontology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Health maintenance through home-based interventions for community-dwelling older people with sarcopenia during and after the COVID-19 pandemic: A systematic review and meta-analysis

Kor

Sui

et al. 2023

Experimental Gerontology

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“…Nasimi et al have investigated the efficacy of a HMB-fortified yogurt compared to plain yogurt in community older adults with sarcopenia (N = 66) [29]. Fortified yogurt consumption resulted in a significant improvement in gait speed, handgrip strength and physical component of health-related quality of life.…”

Section: Nutritional Therapy As Reactive Strategymentioning

confidence: 99%

Role of muscle-targeted nutritional therapy: new data

Cereda

Veronese

Caccialanza

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewTo provide an updated overview of recent efficacy data on the use of muscle-targeted nutritional therapy, which should consider the optimization of protein and essential amino acids intakes, possibly in combination with supplementation with vitamin D (correction of deficiency/insufficiency status) and v-3 fatty acids. Recent findingsIntervention studies conducted in the last years in different healthcare settings and heterogeneous patient populations support the use of muscle-targeted oral nutritional supplementation to improve muscle mass, function and physical performance in patients with sarcopenia. Higher efficacy is likely to be achieved in combination with individually tailored resistance exercise training programs and when nutritional therapy and the provision of specific nutrients result in an adequate protein-calorie balance. However, not only a reactive but also a pro-active application of this therapy could be proposed as evidence exists on the maintenance of or improvement in the same outcome variables in patients at risk of losing skeletal muscle mass.

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“…Decreased levels of insulin-like growth factor-1 (IGF-1) were reported in age-related conditions such as sarcopenia [ 58 , 59 ], diabetes, cardiovascular diseases, frailty, and the like [ 60 , 61 ] (117, 121 of 4). Activation of the receptors for IGF-1 can upregulate the PI3K/AKT pathway, and this can promote cell survival and decrease cell senescence [ 62 ].…”

Section: Olive Oilmentioning

confidence: 99%

Trends in Natural Nutrients for Oxidative Stress and Cell Senescence

Omidifar

Moghadami

Mousavi

et al. 2021

Oxidative Medicine and Cellular Longevity

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Due to the increase in the aged population and increased life expectancy, the underlying mechanisms involved in the aging process and cell senescence and the ways for modulating these processes in age-related diseases become important. One of the main mechanisms involved in aging and cell senescence, especially in the diseases related to aging, is the oxidative stress process and the following inflammation. Hence, the effects of antioxidants are highlighted in the literature due to their beneficial impacts on inhibiting telomere shortening or DNA damage and other processes related to aging and cell senescence in age-related diseases. Dietary components, foods, and dietary patterns rich in antioxidants can modulate the aging process and delay the progression of some chronic diseases such as cardiovascular diseases, diabetes, and Alzheimer’s disease. Foods high in polyphenols, vitamin C, or carotenoids, olive oil, seeds, nuts, legumes, dietary supplements such as CoQ10, and some other dietary factors are the most important nutritional sources that have high antioxidant contents which can positively affect cell senescence and disease progression. Plant dietary patterns including Mediterranean diets can also inhibit telomere shortening following oxidative damages, and this can delay cell aging and senescence in age-related diseases. Further, olive oil can inhibit protein aggregation in Alzheimer’s disease. It can be concluded that nutrition can delay the process of cell senescence in age-related diseases via inhibiting oxidative and inflammatory pathways. However, more studies are needed to better clarify the underlying mechanisms of nutrition and dietary components on cell senescence, aging, and disease progression, especially those related to age.

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A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial

Cited by 21 publications

References 43 publications

Health maintenance through home-based interventions for community-dwelling older people with sarcopenia during and after the COVID-19 pandemic: A systematic review and meta-analysis

Health maintenance through home-based interventions for community-dwelling older people with sarcopenia during and after the COVID-19 pandemic: A systematic review and meta-analysis

Role of muscle-targeted nutritional therapy: new data

Trends in Natural Nutrients for Oxidative Stress and Cell Senescence

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