A novel form of oxytocin in New World monkeys

Lee, Alex G.; Cool, David R.; Grunwald, William C.; Neal, Donald; Buckmaster, Christine L.; Cheng, Michelle Y.; Hyde, Shellie A.; Lyons, David M.; Parker, Karen J.

doi:10.1098/rsbl.2011.0107

Cited by 80 publications

(57 citation statements)

References 11 publications

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“…In these two species evidence for an unusual OT-like peptide was obtained -Pro 8 OT, confirming the recent report of Lee et al [20]. Pro rather than Leu at position 8…”

Section: Novel Eutherian Neurohypophysial Hormonessupporting

confidence: 80%

“…For tenrec and armadillo the (incomplete) genomic data suggest that there are additional genes/pseudogenes (see text). Marmoset reflects the position in some other, but not all, New World Monkeys [20].…”

Section: Fig2 Diagram Illustrating the Distribution And Organizatiomentioning

confidence: 99%

“…World monkeys and in the tree shrew (Tupaia belangeri) [20]. In all cases studied genes encoding the precursors of these peptides in Eutheria are adjacent on the same chromosome (chromosome 20 in man), arranged tail-to-tail (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Molecular evolution of the neurohypophysial hormone precursors in mammals: Comparative genomics reveals novel mammalian oxytocin and vasopressin analogues

Wallis

2012

General and Comparative Endocrinology

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Among vertebrates the neurohypophysial hormones show considerable variation. However, in eutherian mammals they have been considered rather conserved, with arginine vasopressin (AVP) and oxytocin (OT) in all species except pig and some relatives, where lysine vasopressin replaces AVP. The availability of genomic data for a wide range of mammals makes it possible to assess whether these peptides and their precursors may be more variable in Eutheria than previously suspected. A survey of these data confirms that AVP and OT occur in most eutherians, but with exceptions. In a New-World monkey (marmoset, Callithrix jacchus) and in tree shrew (Tupaia

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“…In these two species evidence for an unusual OT-like peptide was obtained -Pro 8 OT, confirming the recent report of Lee et al [20]. Pro rather than Leu at position 8…”

Section: Novel Eutherian Neurohypophysial Hormonessupporting

confidence: 80%

Section: Fig2 Diagram Illustrating the Distribution And Organizatiomentioning

confidence: 99%

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Molecular evolution of the neurohypophysial hormone precursors in mammals: Comparative genomics reveals novel mammalian oxytocin and vasopressin analogues

Wallis

2012

General and Comparative Endocrinology

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“…However, Lee and colleagues (8) reported a T > C change in four New World monkeys (NWms), Saimiri sciureus, Cebus apella, Callithrix jacchus, and Aotus nancimae, substituting leucine to proline at position 8 (OXT8Pro). This form was also found in Tupaia belangeri, a tree shrew species of Southeast Asia (8). OXT differs from its paralog vasopressin (AVP; Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly) at positions 3 and 8.…”

mentioning

confidence: 97%

Evolutionary pattern in the OXT-OXTR system in primates: Coevolution and positive selection footprints

Vargas-Pinilla

Paixão‐Côrtes

Paré

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Oxytocin is a nonapeptide involved in a wide range of physiologic and behavioral functions. Until recently, it was believed that an unmodified oxytocin sequence was present in all placental mammals. This study analyzed oxytocin (OXT) in 29 primate species and the oxytocin receptor (OXTR) in 21 of these species. We report here three novel OXT forms in the New World monkeys, as well as a more extensive distribution of a previously described variant (Leu8Pro). In structural terms, these OXTs share the same three low-energy conformations in solution during molecular dynamic simulations, with subtle differences in their side chains. A consistent signal of positive selection was detected in the Cebidae family, and OXT position 8 showed a statistically significant (P = 0.013) correlation with litter size. Several OXTR changes were identified, some of them promoting gain or loss of putative phosphorylation sites, with possible consequences for receptor internalization and desensitization. OXTR amino acid sites are under positive selection, and intramolecular and intermolecular coevolutionary processes with OXT were also detected. We suggest that some New World monkey OXT-OXTR forms can be correlated to male parental care through the increase of cross-reactivity with its correlated vasopressin system.OXT | OXTR | primates | coevolution | behavior

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“…Prior to water-land transition, IT was replaced by mesotocin (MT), which is mostly present in extant lungfish, amphibians, reptiles, and birds 57 . Finally, MT was replaced by OT in most mammals [58][59][60] . Cartilaginous fishes have evolved at least six OT-like peptides, including the mammalian OT form 61 .…”

Section: Introductionmentioning

confidence: 99%

Gene expression correlates of social evolution in coral reef butterflyfishes

Nowicki

Pratchett

Coker

et al. 2017

Preprint

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Pair bonding has independently evolved numerous times among vertebrates. The governing neural mechanisms of pair bonding have only been studied in depth in the mammalian model species, the prairie vole, Microtus ochrogaster. In this species, oxytocin (OT), arginine vasopressin (AVP), dopamine (DA), and opioid (OP) systems play key roles in signaling in the formation and maintenance of pair bonding by targeting specific social and reward-mediating brain regions. By contrast, the neural basis of pair bonding is poorly studied in other vertebrates, and especially those of early origins, limiting our understanding of the evolutionary history of pair bonding regulatory mechanisms. We compared receptor gene expression between pair bonded and solitary individuals across eight socio-functional brain regions. We found that in females, ITR and V1aR receptor expression varied in the lateral septum-like region (the Vv/Vl), while in both sexes D1R, D2R, and MOR expression varied within the mesolimbic reward system, including a striatum-like region (the Vc); mirroring sites of action in M. ochrogaster. This study provides novel insights into the neurobiology of teleost pair bonding. It also reveals high convergence in the neurochemical mechanisms governing pair bonding across actinopterygians and sarcopterygians, by repeatedly co-opting and similarly assembling deep neurochemical and neuroanatomical homologies that originated in ancestral osteithes.

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A novel form of oxytocin in New World monkeys

Cited by 80 publications

References 11 publications

Molecular evolution of the neurohypophysial hormone precursors in mammals: Comparative genomics reveals novel mammalian oxytocin and vasopressin analogues

Molecular evolution of the neurohypophysial hormone precursors in mammals: Comparative genomics reveals novel mammalian oxytocin and vasopressin analogues

Evolutionary pattern in the OXT-OXTR system in primates: Coevolution and positive selection footprints

Gene expression correlates of social evolution in coral reef butterflyfishes

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