A novel folic acid hydrogel loading β-cyclodextrin/camptothecin inclusion complex with effective antitumor activity

Ma, Mingfang; Shang, Wen-Qing; Jia, Ruxiao; Chen, Ruijiao; Zhao, Min; Wang, Chaoqun; Tian, Mingyan; Yang, Shulei; Hao, Aiyou

doi:10.1007/s10847-019-00962-2

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…According to the previous literature, Ma et al demonstrated that the β-CD-loaded folic acid hydrogel was more thermally stable than a hydrogel without β-CD. 25 Similarly, another study by Sharkir et al revealed that the addition of β-CD, in a chitosan/nano-hydroxyapatite complex, increased the thermal stability as compared to an unmodified sample. 26 These results indicate that the modification of β-CD on the CTS ENs can improve thermal stability due to chemical conjugation on the surface.…”

Section: Resultsmentioning

confidence: 95%

“…However, βCTS ENs seemed to withstand thermal decomposition better than unmodified CTS ENs. According to the previous literature, Ma et al demonstrated that the β-CD-loaded folic acid hydrogel was more thermally stable than a hydrogel without β-CD . Similarly, another study by Sharkir et al revealed that the addition of β-CD, in a chitosan/nano-hydroxyapatite complex, increased the thermal stability as compared to an unmodified sample .…”

Section: Resultsmentioning

confidence: 99%

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Facile Preparation of β-Cyclodextrin-grafted Chitosan Electrospun Nanofibrous Scaffolds as a Hydrophobic Drug Delivery Vehicle for Tissue Engineering Applications

Lee

Nah

et al. 2021

ACS Omega

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Despite advances in the bio-tissue engineering area, the technical basis to directly load hydrophobic drugs on chitosan (CTS) electrospun nanofibers (ENs) has not yet been fully established. In this study, we fabricated CTS ENs by using an electrospinning (ELSP) system, followed by surface modification using succinyl-beta-cyclodextrin (β-CD) under mild conditions. The β-CD-modified CTS (βCTS) ENs had slightly increased hydrophobicity compared to pristine CTS ENs as well as decreased residual amine content on the surface. Through FTIR spectroscopy and thermogravimetric analysis (TGA), we characterized the surface treatment physiochemically. In the drug release test, we demonstrated the stable and sustained release of a hydrophobic drug (e.g., dexamethasone) loaded on β-CD ENs. During in vitro biocompatibility assessments, the grafting of β-CD was shown to not reduce cell viability compared to pristine CTS ENs. Additionally, cells proliferated well on β-CD ENs, and this was confirmed by Factin fluorescence staining. Overall, the material and strategies developed in this study have the potential to load a wide array of hydrophobic drugs. This could be applied as a drug carrier for a broad range of tissue engineering applications.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%