A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

Zhan, Yu-Rong; He, Xi; Huang, Zhi-Ying; Chen, Ping; Tian, Miao-Miao; Li, Guo-Hong; Yu, Xiao-Qi; Song, Xiang-Rong; Zhang, Ji

doi:10.1039/d3tb01531a

J. Mater. Chem. B

2023

DOI: 10.1039/d3tb01531a

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A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

Yu-Rong Zhan,

Xi He,

Zhi-Ying Huang

et al.

Abstract: The insufficient treatment of protein-based nanovaccines is largely attributed to their inadequate immunogenicity. Herein, we developed a novel fluoropolymer (PF) via the ring-opening polymerization and constructed the fluoropolymer-based nanovaccine for...

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2024

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Fluorinated Organic Polymers for Cancer Drug Delivery

Xin,

Lu,

Cao

et al. 2024

Advanced Materials

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In the realm of cancer therapy, the spotlight is on nanoscale pharmaceutical delivery systems, especially polymer‐based nanoparticles, for their enhanced drug dissolution, extended presence in the bloodstream, and precision targeting achieved via surface engineering. Leveraging the amplified permeation and retention phenomenon, these systems concentrate therapeutic agents within tumor tissues. Nonetheless, the hurdles of systemic toxicity, biological barriers, and compatibility with living systems persist. Fluorinated polymers, distinguished by their chemical idiosyncrasies, are poised for extensive biomedical applications, notably in stabilizing drug metabolism, augmenting lipophilicity, and optimizing bioavailability. Material science heralds the advent of fluorinated polymers that, by integrating fluorine atoms, unveil a suite of drug delivery merits: the hydrophobic traits of fluorinated alkyl chains ward off lipid or protein disruption, the carbon‐fluorine bond's stability extends the drug's lifecycle in the system, and a lower alkalinity coupled with a diminished ionic charge bolsters the drug's ability to traverse cellular membranes. This comprehensive review delves into the utilization of fluorinated polymers for oncological pharmacotherapy, elucidating their molecular architecture, synthetic pathways, and functional attributes, alongside an exploration of their empirical strengths and the quandaries they encounter in both experimental and clinical settings.This article is protected by copyright. All rights reserved

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Fluorinated Organic Polymers for Cancer Drug Delivery

Xin,

Lu,

Cao

et al. 2024

Advanced Materials

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Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Ding,

Agrawal,

Singh

et al. 2024

Polymers

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Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, the off-target effects of chemotherapy are known to produce side effects and dose-limiting toxicities. Novel delivery platforms based on natural and synthetic polymers with enhanced pharmacokinetic and therapeutic potential for the treatment of cancer have grown tremendously over the past 10 years. Polymers can facilitate selective targeting, enhance and prolong circulation, improve delivery, and provide the controlled release of cargos through various mechanisms, including physical adsorption, chemical conjugation, and/or internal loading. Notably, polymers that are biodegradable, biocompatible, and physicochemically stable are considered to be ideal delivery carriers. This biomimetic and bio-inspired system offers a bright future for effective drug delivery with the potential to overcome the obstacles encountered. This review focuses on the barriers that impact the success of chemotherapy drug delivery as well as the recent developments based on natural and synthetic polymers as platforms for improving drug delivery for treating cancer.

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A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

Abstract: The insufficient treatment of protein-based nanovaccines is largely attributed to their inadequate immunogenicity. Herein, we developed a novel fluoropolymer (PF) via the ring-opening polymerization and constructed the fluoropolymer-based nanovaccine for...

Cited by 2 publications

References 28 publications

Fluorinated Organic Polymers for Cancer Drug Delivery

Fluorinated Organic Polymers for Cancer Drug Delivery

Polymer-Based Drug Delivery Systems for Cancer Therapeutics

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