A novel fluorescence “turn off-on” sensor based on N-doped graphene quantum dots in amino acid ionic liquid medium and its application

Liu, Wei; Zhu, Xiashi

doi:10.1016/j.talanta.2019.01.008

Cited by 26 publications

(9 citation statements)

References 34 publications

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“…Further, we have utilized the prepared C-Dots for sensing of the protein samples by using the “chemical nose/tongue” method. − In earlier reports, C-Dots were used for sensing bioanalytes mostly based on the specific “on–off” method. , The “chemical nose/tongue” method provides an alternative to the specific sensing protocol. In this strategy, a sensor array is required to build with a certain level of selectivity.…”

Section: Results and Discussionmentioning

confidence: 99%

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In Situ Synthesis of Amino Acid Functionalized Carbon Dots with Tunable Properties and Their Biological Applications

Pandit

Behera

Sahoo

et al. 2019

ACS Appl. Bio Mater.

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Emissive carbon dots (C-Dots) are known for displaying versatile properties, which have been widely utilized in many applications such as bioimaging, light-emitting devices, and photocatalysis. Further functionalization can tune their physical and chemical properties, which play the key role in many biologically and chemically relevant applications. Amino acids provide an attractive means for introducing functionality with a structural diversity. In this work, water-soluble emissive C-Dots were synthesized from pyrolysis of citric acid in the presence of various amino acids under hydrothermal conditions. We established that the diverse functionality-bearing polyamides and the polyester backbone of C-Dots are the origin of optical properties with a high quantum yield. The amino acid based C-Dots were systematically characterized using various analytical methods to confirm the core structure as well as the functionality. The results show that, depending on functionalization, the quantum yield can be varied and enhanced up to 62% and surface charge and hydrophobicity can be tuned. Most importantly, we observed a correlation between the quantum yield and properties of the side chain residue of amino acids such as hydrophobicity index and volume. Furthermore, it was found that the synthesized, diversely functionalized C-Dots exhibit no cellular toxicity and can be used for cell imaging. Due to variable surface functionality, we have also applied these C-Dots for array-based protein sensing. Overall, based on this reported method, we can easily tune the optical as well as surface properties of C-Dots, which will be suitable for many future applications.

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Section: Results and Discussionmentioning

confidence: 99%

“…53−55 In earlier reports, C-Dots were used for sensing bioanalytes mostly based on the specific "on−off" method. 37,56 The "chemical nose/ tongue" method provides an alternative to the specific sensing protocol. In this strategy, a sensor array is required to build with a certain level of selectivity.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

In Situ Synthesis of Amino Acid Functionalized Carbon Dots with Tunable Properties and Their Biological Applications

Pandit

Behera

Sahoo

et al. 2019

ACS Appl. Bio Mater.

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“…Both Cu 2+ and levodopa can be quantified by fluorescence spectrophotometry. [ 247 ] And in a more macroscopic application, 1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)imide has been used to create an ultra‐sensitive, flexible pressure sensor skins. [ 245 ] As ionic liquids improve biosensor technology, the ability to detect markers of disease and tightly control drug doses will allow doctors to more easily and successfully treat disease.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Ionic Liquids in Biomedicine

2021

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The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

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“…Over the last few decades, some methods and strategies for monitoring pH, which include titration, electrochemistry, absorbance spectroscopy, etc., [ 13–21 ] have been reported. Among these methods, fluorescent probes have become highly promising as detection methods in biological research and clinical diagnosis due to their various advantages such as high fluorescence response, simple operation, superior sensitivity, and selectivity.…”

Section: Introductionmentioning

confidence: 99%

A novel aggregation‐induced emission fluorescent probe with large Stokes shift for sensitive detection of pH changes in live cells

Zhang

Wang

et al. 2022

Luminescence

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The detection of intracellular pH is crucial for elucidating the pathological process of cancers, as well as for medical diagnostic applications. Here, we developed an aggregation-induced emission active pH-responsive fluorescent probe (TPE-DCP) for sensitively detecting cell pH changes. The probe shows obvious pH-sensing properties at $615 nm, with a pKa value of 6.82 and a good linear pH response ranging from 8.5 to 4.5. TPE-DCP holds advantages such as excellent anti-interference performance, good photostability, and low cytotoxicity, and has been successfully used to image intracellular pH changes in cells.

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A novel fluorescence “turn off-on” sensor based on N-doped graphene quantum dots in amino acid ionic liquid medium and its application

Cited by 26 publications

References 34 publications

In Situ Synthesis of Amino Acid Functionalized Carbon Dots with Tunable Properties and Their Biological Applications

In Situ Synthesis of Amino Acid Functionalized Carbon Dots with Tunable Properties and Their Biological Applications

Recent Advances in Ionic Liquids in Biomedicine

A novel aggregation‐induced emission fluorescent probe with large Stokes shift for sensitive detection of pH changes in live cells

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