A novel fluorescence and resonance Rayleigh scattering probe based on quantum dots for the detection of albendazole

Qin, Li; Tan, Xuanping; Fu, Lingli; Qu, Lijun; Tang, Weiwei

doi:10.1039/c4ay02289k

Cited by 16 publications

(6 citation statements)

References 46 publications

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“…Lately, the research in nanoscience opened an even wider pathway in fluorescence studies involving ion pairing. Quantum dots (QDs) are prone to exchange electrons with their complementary partners (acceptors or donors) upon excitation that can be transduced into detectable fluorescent signals [70]. Thus, sensitive assay methods can be developed by using QDs capped with different ligands in ionized form.…”

Section: Fluorescence Spectroscopymentioning

confidence: 99%

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Ion-Pair Spectrophotometry in Pharmaceutical and Biomedical Analysis: Challenges and Perspectives

Florea¹,

Ilie²

2017

Spectroscopic Analyses - Developments and Applications

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Experimental and theoretical studies of the mechanisms that underlay ion-pair formation, their properties and applications in various fields have been and still are focused by researchers since the introduction of the concept in 1926, by Bjerrum. Ion pairs are distinct chemical entities, electrically neutral, formed between ions of opposite charge and held together by Coulomb forces, without formation of a covalent bond. Investigation methods used are various, from classical conductometric measurements to up-to-date methods, such as spectrophotometry, chromatography and capillary electrophoresis. In the pharmaceutical field, ion pairs were used to develop methods of separation, identification and assay for the active substances in complex matrices, to obtain pharmaceutical formulations with controlled release and to explain the mechanisms of transport and action for certain drugs. The chapter is an attempt to describe new trends in the spectrophotometry of ion pairs and their applications in the pharmaceutical field. The development of the concept and types of ion pairs are first presented; further, examples of applications using molecular absorption, fluorimetry and resonance light scattering spectrophotometry are presented. Based on the literature data and the authors' experience in the field, challenges and perspectives in the ion-pair spectrophotometry are also considered.

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Section: Fluorescence Spectroscopymentioning

confidence: 99%

“…An example is the determination method developed for albendazole, using glutathione-capped cadmium telluride QDs (GSH-CdTe QDs). Ion-pair equilibrium takes place between albendazole in cationic form and anionic sites at the QD surface, and the effect was a decrease of the fluorescence intensity of capped CdTe QDs [70].…”

Section: Fluorescence Spectroscopymentioning

confidence: 99%

Ion-Pair Spectrophotometry in Pharmaceutical and Biomedical Analysis: Challenges and Perspectives

Florea¹,

Ilie²

2017

Spectroscopic Analyses - Developments and Applications

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“…19 presented an ultrasensitive colorimetric/fluorescent sensor to detect Hg 2+ , and the detetion limits of the two modes were both below 10 nM. RRS, a convenient and sensitive molecular spectroscopy, can combine with fluorescence to develop some sensitive fluorescence and RRS dual-model methods 21,22 . For example, based on the changes of fluorescence and RRS intensity after the addition of albendazole (ABZ) to CdTe quantum dots system, Li et al .…”

Section: Introductionmentioning

confidence: 99%

“…For example, based on the changes of fluorescence and RRS intensity after the addition of albendazole (ABZ) to CdTe quantum dots system, Li et al . proposed a dual-model fluorescence/RRS technique to determine ABZ with the DL of nanogram level 21 . Fu et al .…”

Section: Introductionmentioning

confidence: 99%

A dual-model SERS and RRS analytical platform for Pb(II) based on Ag-doped carbon dot catalytic amplification and aptamer regulation

Wang

Huang

Wen

et al. 2019

Sci Rep

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Several carbon dots doping with diferent elements (Ca, Ag, Au) were fabricated and their catalytic properties had been investigated in this paper. It was found that the Ag-doped carbon dots (CD Ag ) had played a role of mimic enzyme on the reaction of HAuCl 4 -H 2 O 2 and generated nanogold particles with surface enhanced Raman scattering (SERS) and resonance Rayleigh scattering (RRS) effects. The aptamer (Apt) can be adsorbed on the CD Ag surface and cause the catalysis weakening. When the target Pb(II) was added, it would combine with the Apt to produce firm complexes Pb-Apt and desorb CD Ag , which caused its catalytic effect restore. The formed nanogold had a strong RRS peak (at 375 nm) and a high SERS peak (at 1615 cm −1 ) in the presence of molecular probe (Victoria blue B, VBB). The dual-model signals of SERS and RRS increased linearly with Pb(II) concentration increase within the scope of 0.006–0.46 μmol/L and 0.01–0.46 μmol/L. And their detection limits respectively were 0.0032 μmol/L and 0.0048 μmol/L Pb(II).

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“…Recent studies indicated it as having antitumor effect in various forms of cancer [18] and Alzheimer disease [29]. Thus, elucidation of action mechanism, obtaining pharmaceutical forms with controlled release [15] and development of new rapid and sensitive assay methods are studies of great interest [12]. The completion of the analytical profile of pharmaceutical substances with the ability to form ion pairs with various counterions is useful mainly for drug control but also for pharmaceutical technology, by obtaining new formulations with predictable biodisponibility, and in pharmacological studies, ion pairing being one of the mechanisms of the absorption [6].…”

Section: Introductionmentioning

confidence: 99%

A New Non-Extractive Ion-Pair Spectrophotometric Method for the Assay of Albendazole

Florea¹

2019

FARMACIA

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The paper presents a new non-extractive spectrophotometric method for the assay of albendazole (ABZ) as ion pair with Congo red (CR). A soluble and stable ion pair (ABZ-CR) with an absorption maximum at 294 nm was obtained using a 2•10 -8 M CR concentration and Britton Robinson (BR) buffer with pH = 2.5. The method is linear in the range 2.5 -4.7 µg/mL, with limits of detection and quantification of 0.09 µg/mL and 0.28 µg/mL, respectively. The proposed method was applied to the assay of ABZ in bulk pharmaceutical substance. Because CR is a dye with pharmacological applications used as model in biochemical studies, the research also focused on the mechanism of interaction with ABZ. Spectral changes and physicochemical constants (conductivity, dielectric constant) indicated that ABZ-CR ion pairing takes place at the surface of CR aggregates by electrostatic and charge transfer interactions. RezumatLucrarea prezintă o nouă metodă spectrofotometrică non-extractivă de dozare a albendazolului (ABZ) ca pereche de ioni cu roșu de Congo (CR). Perechea de ioni (ABZ-CR), solubilă și stabilă, cu maxim de absorbție la 294 nm s-a obținut folosind o concentrație de CR de 2•10 -8 M și soluție tampon Britton-Robinson (BR) cu pH = 2,5. Metoda este liniară pe domeniul de concentrații 2,5 -4,7 µg/mL, cu limita de detecție de 0,09 µg/mL și limita de cuantificare de 0,28 µg/mL. Metoda a fost aplicată la dozarea substanței farmaceutice ABZ. Deoarece CR este un indicator cu proprietăți farmacologice și folosit ca model în studiile de biochimie, studiul a avut în vedere și stabilirea mecanismului de interacțiune cu ABZ. Modificările spectrale și constantele fizico-chimice (conductivitate, constantă dielectrică) au aratat că perechea de ioni ABZ-CR se formează la suprafața agregatelor de CR prin interacțiuni electrostatice și transfer de sarcină.

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A novel fluorescence and resonance Rayleigh scattering probe based on quantum dots for the detection of albendazole

Abstract: Glutathione (GSH)-capped CdTe QDs with diameters of 3 nm were synthesised.

Cited by 16 publications

References 46 publications

Ion-Pair Spectrophotometry in Pharmaceutical and Biomedical Analysis: Challenges and Perspectives

Ion-Pair Spectrophotometry in Pharmaceutical and Biomedical Analysis: Challenges and Perspectives

A dual-model SERS and RRS analytical platform for Pb(II) based on Ag-doped carbon dot catalytic amplification and aptamer regulation

A New Non-Extractive Ion-Pair Spectrophotometric Method for the Assay of Albendazole

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