A novel flower-shaped Ag@ZIF-67 chemiluminescence sensor for sensitive detection of CEA

Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

“…The synthesized system ATh/Mg/NC-0.8/TMB successfully detected ACh with a low LOD of 0.0001 U L −1 . Addressing antigens, Hou et al 95 devised a novel chemiluminescence sensing platform using Ag@ZIF-67 to detect carcinoembryonic antigens via base complementation between an aptamer and DNA strand. Their results showcased a wide linear detection range (0.0001–5 ng mL −1 ) and a low detection limit of 0.00453 ng mL −1 .…”

Simultaneous Assay of CA 72-4, CA 19-9, CEA and CA 125 in Biological Samples Using Needle Three-Dimensional Stochastic Microsensors

“…In comparison to other tools and methods proposed to date (including an ultrasensitive electrochemical immune sensor proposed for the assay of CA 72-4 by Yan et al [47]; an electrochemical sensor proposed for the simultaneous assay of CA19-9 and CA 72-4, which was based on tumor marker dual recognition via glycosyl imprinting and lectin-specific binding, proposed by Luo et al [48]; an ultrasensitive split-type electrochemical immunosensor based on the controlled-released strategy proposed by Li et al for the assay of CA 19-9 [49]; a photoelectrochemical immunosensor proposed by Gholamin et al for the assay of CA 19-9 [50]; a flower-shaped chemiluminescence-based sensor for the assay of CEA [51]; a magnetic copper silicate and boronic acid conjugate AuNCs@keratin-based electrochemical/fluorescent dual sensor proposed by Jin et al for the determination of CEA [52]; for the assay of CA 125, a hydrogel-based immunosensor proposed by Er et al [53]; and a label-free dual immunosensor proposed by Kamac et al [54]), the needle 3D stochastic microsensors proposed in this paper had the following advantages: The developed sensors exhibit reliable molecular recognition capabilities for CA 72-4, CA 19-9, CEA and CA 125, and they demonstrate wider working concentration ranges compared to those documented in the referenced papers. Additionally, the sensors achieve lower limits of determination and higher sensitivities, and their design, which does not involve the use of biomolecules, contributes to their enhanced stability over time.…”

Electrochemical study of the Cu²⁺ sensor based on ZIF-67/MWCNTs/Nafion

“…It is considered as an ideal material for electrode modification due to its large surface area, uniform distribution of pores and good adsorption properties. The cobalt-based imidazolate zeolite skeleton (ZIF-67) with rhombic dodecahedral structure is widely used in the field of sensors for food analysis [7,8], biomedicine [9,10], and environmental monitoring [11][12][13] due to its good adsorption capacity. Therefore, ZIF-67 was selected as an electrode modification material to construct an electrochemical sensing platform for detecting heavy metal ions.…”