A novel fast disintegrating tablet fabricated by three-dimensional printing

Yu, Deng‐Guang; Branford-White, Christopher; Yang, Yicheng; Zhu, Li‐Min; Welbeck, Edward William; Yang, Xiangliang

doi:10.3109/03639040903059359

Cited by 94 publications

(35 citation statements)

References 18 publications

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“…The friability revealed no variations and was demonstrated to be 0% for all the formulation. Unlike tablets generated from other 3D printed technologies such as EXT (Khaled et al, 2014a) and powder-based 3D printing (Katstra et al, 2000b;Yu et al, 2009), the friability of tablets generated using via FDM 3D printing tends to be very low or even zero (Goyanes et al, 2014a;Goyanes et al, 2015c;Pietrzak et al, 2015).…”

Section: Resultsmentioning

confidence: 93%

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Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Sadia

Sośnicka

Arafat

et al. 2016

International Journal of Pharmaceutics

268

147

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Abstract*Corresponding author: MAlbedAlhnan@uclan.ac.uk This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with various model drugs. It investigates the addition of nonmelting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of i) the nature of filler, ii) compatibility with the gears of the 3D printer and, and iii) polymer: filler ratio on the 3D printing process. A specially developed filament based on pharmaceutically approved methacrylic polymer (Eudragit E) and thermally stable filler, TCP (tribasic calcium phosphate) was optimised. Four model drugs (with different physicochemical properties were included into ready-to-use mechanically stable tablets with immediate release properties. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135 o C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet. Following the two thermal processes (hot melt extrusion (HME) and fused deposition modelling (FDM) 3D printing), drug contents were 94.22%, 88.53%, 96.51% and 93.04% for 5-ASA, captopril, theophylline and prednisolone respectively. XRPD indicated that a fraction of 5-ASA, theophylline and prednisolone remained in the crystalline form whilst captopril was in amorphous form. By combining the advantages of thermally stable pharmaceutically approved polymers and fillers, this unique approach provides a low cost production method for on demand manufacturing of individualised dosage forms.

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Section: Resultsmentioning

confidence: 93%

“…However, the technology produces tablets of poor mechanical properties and surface imperfections (Katstra et al, 2000b;Pham and Gault, 1998;Yu et al, 2009). Powderspecialised facilities with potential wastage are less suitable for small-scale production in a community or hospital pharmacies (Huang et al, 2013).…”

mentioning

confidence: 99%

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Sadia

Sośnicka

Arafat

et al. 2016

International Journal of Pharmaceutics

268

147

View full text Add to dashboard Cite

show abstract

“…Yu et al (2007) employed the method to construct a methacrylic or ethylcellulose matrix tablet to achieve a linear release of diclofenac sodium (59). The ability to construct complex formulation designs, even ones with loose powders in its inner regions, was also demonstrated using PB 3D printing (37,61). A PB 3D printed core-shell structure containing the drug pseudoephedrine hydrochloride was also constructed and drug release was shown to be nearly at zero order (60).…”

Section: A Stereolithographic 3d Printing (Sla)mentioning

confidence: 99%

“…This was exhibited in their higher friability values (3.55 %) (37) compared to conventional tablets (81,97). However, significant improvement have been achieved through a more resistant shell structure in a shell-core tablet design (37).…”

Section: Nevertheless Pietrzak Et Al (2014) Showed Improved Tablet mentioning

confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such as extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, including design flexibility and control and manufacture which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

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“…Unlike conventional tablets which break unequally and lose its mass after splitting, the precise control over the geometry and amount of these ingredients can lead to the tablets with intended dissolution profiles based on the patient. Focusing on the patient-centric drug product development, the release profiles of chlorpheniramine and acetaminophen tablets were modified 12,13 . By means of 3D printing technology, dosage form adjustment according to the patient's body weight and lifestyle has been also applied to multifunctional drug delivery systems.…”

Section: Application In Pharmaceutical Field Drug Dosage and Deliverymentioning

confidence: 99%

Usage of 3d Printer Technology in Medical and Pharmaceutical Fields: A Review

Beskan¹,

Yapar²

2019

Univ J Pharm Res

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Along with the developing technology, 3D printers have found broad applications in medical and pharmaceutical fields. Precise digital control over layer by layerprinting given by 3D printers allows drugs, cosmetics and medical devices like prostheses to be personalized for treatment. Additionaly, the physical structure of 3D printed productsand theirvisualization is effective on surgical planning, educational and research applications alleviating the endeavior of surgeons,students and scientists, respectively. Since FDA’s first 3D printed drug approval in 2015, the research for new approaches has been growing although the manufacturers need regularity certainty. However this technology exists for a long time and it is of public interest now due to the approval of 3-D printed tablet and other medical devices and also with the advent of USFDA’s guidance on technical considerations specific to devices using additive manufacturing which encompasses 3-dimensional (3D) printing has triggered many thoughts about this technology which needs to be considered for successful delivery of intended product. As for 3D organ printing, it remains the great expectation albeit some attempts. This review is aimed at giving brief explanations about 3D printing achievements and applications in medical and pharmaceutical fields.

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A novel fast disintegrating tablet fabricated by three-dimensional printing

Abstract: 3DP process is able to offer novel methods for preparing FDTs.

Cited by 94 publications

References 18 publications

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Usage of 3d Printer Technology in Medical and Pharmaceutical Fields: A Review

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