A Novel Family of Biodegradable Poly(ester amide) Elastomers

Cheng, Hao; Hill, Paulina S.; Siegwart, Daniel J.; Vacanti, Nathaniel M.; Lytton-Jean, Abigail K. R.; Cho, Seung Woo; Ye, Anne; Langer, Robert; Anderson, Daniel G.

doi:10.1002/adma.201003482

Cited by 41 publications

(50 citation statements)

References 26 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7a). S-shaped behavior is commonly found in tensile tests of various elastomers (Cheng et al 2011; Kanyanta and Ivankovic 2010; Lee et al 2009). Elastomers, such as polyurethanes, are linear segmented copolymer chains and have a structure that consists of loosely coiled domains of polyesters and stiff domains of urethane linkages (Kanyanta and Ivankovic 2010; Oprea and Vlad 2006).…”

Section: Discussionmentioning

confidence: 99%

“…However, at some threshold stress, the coiled domains will untangle/slip past each other, which leads to large displacements with minimal increase in stress. Once the coiled domains have been straightened out, the material will exhibit strain stiffening as the straightened polyester and stiff domains now bear the load (Lee et al 2009; Cheng et al 2011). Our histology studies show that between the digested and undigested regions the ECM in some areas seems undisturbed (highlighted in green) while in other areas, the interconnecting elastic fibers and SMCs are removed (Fig.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Progressive structural and biomechanical changes in elastin degraded aorta

Chow

Mondoñedo

Johnson

et al. 2012

Biomech Model Mechanobiol

View full text Add to dashboard Cite

Aortic aneurysm is an important clinical condition characterized by common structural changes such as the degradation of elastin, loss of smooth muscle cells, and increased deposition of fibrillary collagen. With the goal of investigating the relationship between the mechanical behavior and the structural/biochemical composition of an artery, this study used a simple chemical degradation model of aneurysm and investigated the progressive changes in mechanical properties. Porcine thoracic aortas were digested in a mild solution of purified elastase (5U/mL) for 6, 12, 24, 48, and 96 h. Initial size measurements show that disruption of the elastin structure leads to increased artery dilation in the absence of periodic loading. The mechanical properties of the digested arteries, measured with a biaxial tensile testing device, progress through four distinct stages termed (1) initial-softening, (2) elastomer-like, (3) extensible-but-stiff, and (4) collagen-scaffold-like. While stages 1, 3, and 4 are expected as a result of elastin degradation, the S-shaped stress versus strain behavior of the aorta resulting from enzyme digestion has not been reported previously. Our results suggest that gradual changes in the structure of elastin in the artery can lead to a progression through different mechanical properties and thus reveal the potential existence of an important transition stage that could contribute to artery dilation during aneurysm formation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Progressive structural and biomechanical changes in elastin degraded aorta

Chow

Mondoñedo

Johnson

et al. 2012

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…[14] In terms of addressing concerns on the weak mechanical strength of the existing elastomers, the introduction of urethane or amine groups into polyesters has proved to be an effective way for improving mechanical strength of polyester elastomers. [2, 5, 6, 9, 15] Increasing the cross-linking density may serve as another strategy. [1, 7] However, improving mechanical properties by increasing polymer cross-linking densities and introducing urethane/urea bonds in elastomers sacrafices the limited functional groups for future bioconjugation/functionalizion and also slows the material degradation rate.…”

mentioning

confidence: 99%

Click Chemistry Plays a Dual Role in Biodegradable Polymer Design

et al. 2013

View full text Add to dashboard Cite

“…Cheng et al developed a family of biodegradable PEA elastomers with excellent elasticity, good in vivo biocompatibility and a slow degradation rate,75 they also studied a poly(gamma‐glutamic acid)‐ graft ‐chondroitin sulfate‐ blend ‐poly(epsilon‐caprolactone) composite biomaterial as a scaffold for cartilage tissue engineering and reported excellent biodegradation and biocompatibility for chondrocytes and its potential as temporary substitutes for articular cartilage regeneration 76. Cai et al reported chemically modified poly(aspartic acid) (PAA) as potential biomaterials 77.…”

Section: Pharmaceutical and Biomedical Applicationmentioning

confidence: 99%

Biodegradable Polymers Derived From Amino Acids

Khan

Saravanan

Farah

et al. 2011

Macromolecular Bioscience

View full text Add to dashboard Cite

In the past three decades, the use of polymeric materials has increased dramatically for biomedical applications. Many α-amino acids derived biodegradable polymers have also been intensely developed with the main goal to obtain bio-mimicking functional biomaterials. Polymers derived from α-amino acids may offer many advantages, as these polymers: (a) can be modified further to introduce new functions such as imaging, molecular targeting and drugs can be conjugated chemically to these polymers, (b) can improve on better biological properties like cell migration, adhesion and biodegradability, (c) can improve on mechanical and thermal properties and (d) their degradation products are expected to be non-toxic and readily metabolized/excreted from the body. This manuscript focuses on biodegradable polymers derived from natural amino acids, their synthesis, biocompatibility and biomedical applications. It is observed that polymers derived from α-amino acids constitute a promising family of biodegradable materials. These provide innovative multifunctional polymers possessing amino acid side groups with biological activity and with innumerous potential applications.

show abstract

A Novel Family of Biodegradable Poly(ester amide) Elastomers

Cited by 41 publications

References 26 publications

Progressive structural and biomechanical changes in elastin degraded aorta

Progressive structural and biomechanical changes in elastin degraded aorta

Click Chemistry Plays a Dual Role in Biodegradable Polymer Design

Biodegradable Polymers Derived From Amino Acids

Contact Info

Product

Resources

About