A novel explanation for isotretinoin-induced psychiatric problems and its practical implication

Ghanizadeh, Ahmad; Namazi, Mohammad Reza

doi:10.1111/j.1365-2230.2010.03895.x

Cited by 2 publications

(2 citation statements)

References 6 publications

(7 reference statements)

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“…Additionally, isotretinoin treatment, schizophrenia, and depression have each been associated with elevated homocysteine levels, prompting the suggestion that isotretinoin-induced homocysteine elevation may contribute to psychiatric side effects. 96 …”

Section: Methodsmentioning

confidence: 99%

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Suuberg¹

2019

Current Therapeutic Research

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Highlights Isotretinoin teratogenicity well established; psychiatric effects documented, controversial Disturbed retinoid signaling implicated in isotretinoin teratogenic and psychiatric effects Effect of genetics on susceptibility to psychiatric side effects is possible, not yet known Postnatal neurocognitive effects of isotretinoin not yet established

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Section: Methodsmentioning

confidence: 99%

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Suuberg¹

2019

Current Therapeutic Research

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“…83,94 , 95 Additionally, isotretinoin treatment, schizophrenia, and depression have each been associated with elevated homocysteine levels, prompting the suggestion that isotretinoin-induced homocysteine elevation may contribute to psychiatric side effects. 96 At least 1 author has suggested similarities between genetic intellectual disability syndromes (including forms of autism) and neuroteratogenic syndromes caused by isotretinoin; for example, observing that individuals with Fragile X syndrome and Williams syndrome show neuropsychological profiles similar to those of children exposed to isotretinoin during early embryogenesis. 97…”

Section: Other Psychiatric Case Reportsmentioning

confidence: 99%

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Suuberg¹

2018

SSRN Journal

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Background: An association between isotretinoin (13-cis-retinoic acid, sold under trade names including Accutane [Hoffmann-La Roche Inc, Basel, Switzerland]) and birth defects, depression, and suicide is well documented but controversial. A link to psychosis and exacerbation of bipolar symptoms is less extensively addressed in the literature. Objective: Given recent conceptualization of psychotic disorders as neurodevelopmental, and current interest in possible shared etiology of different neurodevelopmental disorders such as psychosis, autism, and intellectual disability, this review concurrently examines the literature on developmental (primarily teratogenic) and psychiatric side effects of isotretinoin exposure. The goal of concurrent review is to identify shared mechanisms in the literature that may inform future effort s to clarify the neurocognitive and psychiatric effects of isotretinoin exposure at different developmental stages or given different genetic backgrounds. Methods: Literature was obtained by PubMed search for the term isotretinoin in combination with each of the terms psychosis , psychiatric , and teratogenic . Resulting articles met inclusion criteria for review if they addressed psychiatric side effects of isotretinoin treatment or the neurobehavioral teratology of isotretinoin. Results: The association of isotretinoin exposure with prenatal developmental toxicity is well established. Although numerous reports also link isotretinoin treatment with psychiatric side effects, this association remains controversial. Conclusions:The extent to which isotretinoin influences pediatric and adult development and cognition, and whether and why certain individuals may be susceptible to psychiatric side effects, remains to be clarified.

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A novel explanation for isotretinoin-induced psychiatric problems and its practical implication

Cited by 2 publications

References 6 publications

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

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