A Novel Experimental Method for Penile Augmentation Urethroplasty With a Combination of Buccal Mucosa and Amniotic Membrane in a Rabbit Model

Güneş, Mustafa; Altok, Muammer; Özmen, Özlem; Umul, Mehmet; Güneş, Alime; Baş, Ercan; Özyıldız, Zafer; Sönmez, Tolga Taha; Orhan, Hikmet

doi:10.1016/j.urology.2016.10.061

Cited by 11 publications

(15 citation statements)

References 27 publications

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“…Among the most widely used regenerative materials is the placental tissue. The high biocompatibility and low immunogenicity with the presence of several GFs (PDGF-BB, TGF-beta1, bFGF, VEG and TIMP) and cyto kines/chemo kines in amnion recommends its use as alternative or a tissue engineering scaffold in a variety of medical fields, including ophthalmology, gynaecology, urology, pediatrics, neurosurgery, plastic surgery, oral/maxillofacial surgery, wound care (42)(43)(44) .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the amnion structure is similar to the pulp tissue in several aspects. Both of them are soft connective tissues with the presence of monolayer cells in their peripheral zone, i.e., odontoblasts in the pulp tissue and epithelial cells in AM, which gives a notable distinguished similarity (42) . Moreover, accessibility and lower costs can be considered as advantages of the amniotic membrane in comparison with other membranes.…”

Section: Discussionmentioning

confidence: 99%

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Clinical, Radiographical and Histopathological Evaluation of Amniotic Membrane Allograft Pulpotomy in Primary teeth

Beltagy

Yasser

2019

Egyptian Dental Journal

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Background: A novel dehydrated Human Amniotic Membrane (dHAM) allograft is a placental based scaffold that has been widely used in a verity of medical fields due to its unique regenerative ability in wound healing. Objective: To evaluate clinically, radiographically, and histopathologically the efficacy of dehydrated Human Amniotic Membrane allograf as a pulpotomy agent in primary teeth. Materials and Methods: I-Clinical and radiographical evaluation: This split-mouth, randomized clinical trial was conducted on 40 deeply carious primary molars indicated for pulpotomy. They were selected from 16 healthy children aged 4-8 years. They were randomly allocated into two equal groups (20 molars/each). Group 1: dHAM pulpotomy in one quadrant and Group 2: Formocresol (FC) pulpotomy in the contralateral. All molars were treated with the conventional pulpotomy technique. All patients were recalled for clinical and radiographical evaluation at 3, 6, and 9 months post-treatment. II-Histopathological assessment: A total of 30 healthy lower first primary molars and canines that indicated for serial extraction were selected for histopathological evaluation. The dHAM allograft and formocresol pulpotomies were performed (12 teeth/each group), where the other 6 teeth were used as a control. Six teeth from each experimental group were extracted at post-treatment intervals; one and three months. The samples were prepared for histopathological evaluation. All data were subjected to the exact test. Fisher exact test and Monte Carlo test were also used. The level of significance was set at P<0.05. Results: I-Clinical and radiographic results: The overall clinical success rates for both groups were 100%, whereas the overall radiographic success rates for dHAM and FC groups were 100% and 85%, respectively, but the difference was not statistically significant (p>0.05). II-Histopathological results: The overall evaluation at 1-month interval showed better histopathological criteria for dHAM group than FC group, but the difference was only significantly better on the degree of the inflammatory response (p<0.05). Whereas at 3-month interval, the dHAM group displayed significantly better histopathological criteria compared to the FC group (p<0.05). Conclusion: The dHAM allograft with its regenerative, biologic biocompatibility properties and its ability to deliver growth factors has shown successful outcome comparable to gold standard formocresol. Hence, it can be recommended as an alternative promising pulpotomy agent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical, Radiographical and Histopathological Evaluation of Amniotic Membrane Allograft Pulpotomy in Primary teeth

Beltagy

Yasser

2019

Egyptian Dental Journal

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“…The advantages of these processed grafts are that they retain their biologically active growth/regulatory factors over a prolonged shelf life ( 5 , 6 ). This has led to extensive use of dHACM across a variety of fields including ophthalmology, pediatric neurosurgery, gynecology, plastic surgery, wound care, oral/maxillofacial surgery, and urology ( 7 ).…”

mentioning

confidence: 99%

“…There has been a great deal of interest in dHACM as a means of improving outcomes in urological surgery. Studies have highlighted favourable applications in reconstructive surgery, radical prostatectomy, fistula repair, and surgical correction of Peyronie’s disease ( 7 , 14 - 21 ). Burgers et al ( 14 ) were one of the first groups to look at a potential application of amniotic grafts in urology.…”

mentioning

confidence: 99%

“…Amniotic grafts been successfully used in urethral reconstruction in a small number of reports ( 17 ). Unfortunately, amniotic membrane alone is too weak to support augmentation urethroplasty and becomes deformed or tears when used as anastomotic tissue ( 7 ). As such, simultaneous use of dHACM with an additional supportive graft may allow for expanded use in the field of reconstructive urology.…”

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confidence: 99%

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Amnion/chorion grafts and their applications in urology

Akerman

Kovac²

2017

Transl. Androl. Urol.

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Application of amniotic membranes in reconstructive surgery of internal organs—A systematic review and meta‐analysis

Maljaars

Bendaoud

Kastelein

et al. 2022

J Tissue Eng Regen Med

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Amniotic membrane (AM) has great potential as a scaffold for tissue regeneration in reconstructive surgery. To date, no systematic review of the literature has been performed for the applications of AM in wound closure of internal organs. Therefore, in this systematic review and meta‐analysis, we summarize the literature on the safety and efficacy of AM for the closure of internal organs. A systematic search was performed in MEDLINE‐PubMed database and OVID Embase to retrieve human and controlled animal studies on wound closure of internal organs. The Cochrane Risk of Bias tool for randomized clinical trials and the SYRCLE risk of bias tool for animal studies were used. Meta‐analyses (MAs) were conducted for controlled animal studies to assess efficacy of closure, mortality and complications in subjects who underwent surgical wound closure in internal organs with the application of AM. Sixty references containing 26 human experiments and 36 animal experiments were included. The MAs of the controlled animal studies showed comparable results with regard to closure, mortality and complications, and suggested improved mechanical strength and lower inflammation scores after AM application when compared to standard surgical closure techniques. This systematic review and MAs demonstrate that the application of AM to promote wound healing of internal organs appears to be safe, efficacious, and feasible.

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A Novel Experimental Method for Penile Augmentation Urethroplasty With a Combination of Buccal Mucosa and Amniotic Membrane in a Rabbit Model

Cited by 11 publications

References 27 publications

Clinical, Radiographical and Histopathological Evaluation of Amniotic Membrane Allograft Pulpotomy in Primary teeth

Clinical, Radiographical and Histopathological Evaluation of Amniotic Membrane Allograft Pulpotomy in Primary teeth

Amnion/chorion grafts and their applications in urology

Application of amniotic membranes in reconstructive surgery of internal organs—A systematic review and meta‐analysis

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