A novel exogenous concentration-gradient collagen scaffold augments full-thickness articular cartilage repair

Mimura, Tomohiro; Imai, Shunsuke; Kubo, Michinori; Isoya, Eiji; Ando, Kosei; Okumura, Noriaki; Matsusue, Yoshitaka

doi:10.1016/j.joca.2008.02.003

Cited by 45 publications

(48 citation statements)

References 32 publications

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“…113 A recent method suggests a cell-recruitment-based approach with potential for zonal tissue development using a cell-free collagen gradient hydrogel scaffold to recruit MSCs. 114 Other natural materials from nonmammalian sources have been studied extensively in cartilage tissue engineering research, and have also been applied to generate matrix-based constructs with zonal properties. Agarose gels of different concentrations have been seeded with chondrocytes as a model for the depth-dependent mechanical properties of articular cartilage.…”

Section: Matrix-based Approachesmentioning

confidence: 99%

Tissue Engineering of Articular Cartilage with Biomimetic Zones

Klein

Malda

Sah

et al. 2009

Tissue Engineering Part B: Reviews

285

269

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Section: Matrix-based Approachesmentioning

confidence: 99%

Tissue Engineering of Articular Cartilage with Biomimetic Zones

Klein

Malda

Sah

et al. 2009

Tissue Engineering Part B: Reviews

285

269

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“…Recently, cell migration on gradient materials [9] and their potential applications in tissue regeneration [10,11] have attracted more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Gradient biomaterials and their influences on cell migration

et al. 2012

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Cell migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. The cells specifically migrate to destiny sites induced by the gradually varying concentration (gradient) of soluble signal factors and the ligands bound with the extracellular matrix in the body during a wound healing process. Therefore, regulation of the cell migration behaviours is of paramount importance in regenerative medicine. One important way is to create a microenvironment that mimics the in vivo cellular and tissue complexity by incorporating physical, chemical and biological signal gradients into engineered biomaterials. In this review, the gradients existing in vivo and their influences on cell migration are briefly described. Recent developments in the fabrication of gradient biomaterials for controlling cellular behaviours, especially the cell migration, are summarized, highlighting the importance of the intrinsic driving mechanism for tissue regeneration and the design principle of complicated and advanced tissue regenerative materials. The potential uses of the gradient biomaterials in regenerative medicine are introduced. The current and future trends in gradient biomaterials and programmed cell migration in terms of the long-term goals of tissue regeneration are prospected.

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“…Therefore, it has been used to treat fractures, articular defects, and soft tissue damage, and positive clinical results have been reported [Kagawa et al, 2012;Volpi et al, 2014;Kim et al, 2015]. As it is a gel, it can be applied to small defects or to fracture lines that cannot be filled by bone grafts or solid scaffolds, and it remains in the injected area because of its viscosity [Chaipinyo et al, 2004;Mimura et al, 2008;Jeong et al, 2013]. Although some spreading does occur, it is safe, as the main material that constitutes the human body is collagen; hence, atelocollagen does not cause an immune response and it is biodegradable [Yamaoka et al, 2010;Ye et al, 2016].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

Park

Shetty

Kim

et al. 2017

Cells Tissues Organs

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We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which was transplanted into bone defects. Radial shaft defects of about 10 mm in size were created in 30 New Zealand white rabbits. Ten rabbits in the control group were not treated further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate. The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.

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A novel exogenous concentration-gradient collagen scaffold augments full-thickness articular cartilage repair

Abstract: CG collagen scaffold recruits effectively the MSCs to the center of full-thickness cartilage defect and enhances regeneration of the full-thickness cartilage defect.

Cited by 45 publications

References 32 publications

Tissue Engineering of Articular Cartilage with Biomimetic Zones

Tissue Engineering of Articular Cartilage with Biomimetic Zones

Gradient biomaterials and their influences on cell migration

Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

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