A novel enzyme-based antimicrobial system comprising iodide and a multicopper oxidase isolated from Alphaproteobacterium strain Q-1

Yuliana, Tri; Ebihara, Kyota; Suzuki, Miyoko; Shimonaka, Chie; Amachi, Seigo

doi:10.1007/s00253-015-6862-0

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…In contrast, the IOX/iodide system uses oxygen as an electron acceptor, making it a simpler and safer enzyme preparation method. Yuliana et al [44] examined the antimicrobial spectrum of the IOX/iodide system and found that it could completely kill various Gram-negative bacteria, Staphylococcus aureus, and Saccharomyces cerevisiae within 5 min. The system killed Aspergillus niger within 10 min.…”

Section: Potential Application Of Iodidimonasmentioning

confidence: 99%

The Genus Iodidimonas: From Its Discovery to Potential Applications

Amachi

Iino

2022

Microorganisms

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The genus Iodidimonas was recently proposed in the class Alphaproteobacteria. Iodidimonas strains are aerobic, mesophilic, neutrophilic, moderately halophilic, and chemo-organotrophic. They were first discovered in natural gas brine water containing a very high level of iodide (I−). They exhibited a unique phenotypic feature of iodide oxidation to form molecular iodine (I2). Iodidimonas was also enriched and isolated from surface seawater supplemented with iodide, and it is clearer now that their common habitats are those enriched with iodide. In such environments, Iodidimonas species seem to attack microbial competitors with the toxic form I2 to occupy their ecological niche. The iodide-oxidizing enzyme (IOX) purified from the Iodidimonas sp. strain Q-1 exhibited high catalytic efficiency for iodide and consisted of at least two proteins IoxA and IoxC. IoxA is a putative multicopper oxidase with four conserved copper-binding regions but is phylogenetically distinct from other bacterial multicopper oxidases. The IOX/iodide system could be used as a novel enzyme-based antimicrobial system which can efficiently kill Bacillus spores. Furthermore, the IOX/iodide system can be applied to the decolorization of recalcitrant dyes, where iodide may function as a novel inorganic natural redox mediator.

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Section: Potential Application Of Iodidimonasmentioning

confidence: 99%

The Genus Iodidimonas: From Its Discovery to Potential Applications

Amachi

Iino

2022

Microorganisms

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“…inhibited the growth of other sensitive bacteria in the environment, such as E. coli, as demonstrated by Zhao et al (2013). Later, Yuliana et al (2015) suggested that this iodide oxidizing enzyme could be utilized as a novel antimicrobial enzymatic system.…”

Section: Microbial Reduction Of Iodatementioning

confidence: 96%

Microbial involvement in iodine cycle: mechanisms and potential applications

Duborská,

Vojtková,

Matulová

et al. 2023

Front. Bioeng. Biotechnol.

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Stable iodine isotopes are essential for humans as they are necessary for producing thyroid gland hormones. However, there are hazardous radioactive iodine isotopes that are emitted into the environment through radioactive waste generated by nuclear power plants, nuclear weapon tests, and medical practice. Due to the biophilic character of iodine radionuclides and their enormous biomagnification potential, their elimination from contaminated environments is essential to prevent the spread of radioactive pollution in ecosystems. Since microorganisms play a vital role in controlling iodine cycling and fate in the environment, they also can be efficiently utilized in solving the issue of contamination spread. Thus, this paper summarizes all known on microbial processes that are involved in iodine transformation to highlight their prospects in remediation of the sites contaminated with radioactive iodine isotopes.

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“…Q-1. This IOX/iodide system is shown to have antimicrobial and sporicidal properties against wide variety of bacterial strains and spores (27). Because iodide-oxidation by an extracellular enzyme provides no metabolic energy to the microbe, it was proposed to be a strategy to kill other heterotrophic bacteria susceptible to iodine and gain dominance in iodide-rich waters (23, 28).…”

Section: Introductionmentioning

confidence: 99%

Iodidimonas, a bacterium unable to degrade hydrocarbons, thrives in a bioreactor treating oil and gas produced water

Acharya

Enalls

Walian³

et al. 2023

Preprint

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Iodidimonasis a genus recently described in bioreactors treating oil and gas produced water and in iodide rich brines. Besides the ability to oxidize iodine, little is known about the metabolic capabilities that enableIodidimonassp. to occupy this unique ecological niche. We isolated, characterized, and sequenced three strains belonging to theIodidimonasgenus from the sludge of a membrane bioreactor treating produced water. We describe the genomic features of these isolates and compare them with the only other four isolate genomes reported from this genus, as well as a metagenome-assembled genome from the source bioreactor. To survive in the produced water,Iodidimonasisolates had several genes associated with mitigating salinity, heavy metal and organic compound stress. While the isolates could utilize a wide variety of carbon substrates, they failed to degrade aliphatic or aromatic hydrocarbons, consistent with the lack of genes associated with common hydrocarbon degradation pathways in their genomes. We hypothesize these microbes may lead a scavenging lifestyle in the bioreactor and similar iodide-rich brines.ImportanceOccupying a niche habitat and having few representative isolates, genusIodidimonasis a relatively understudied Alphaproteobacterial group. This genus has garnered attention due to its ability to corrode pipes in iodine production facilities and generate iodinated organic compounds during treatment of oil and gas produced water. The iodinated organic compounds are likely to be carcinogenic and may pose issues with recycling the treated water. Hence, detailed characterization of the metabolic potential of these isolates is not only of economic importance, but also sheds light on adaptation of this microbe to its environmental niche.

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A novel enzyme-based antimicrobial system comprising iodide and a multicopper oxidase isolated from Alphaproteobacterium strain Q-1

Cited by 7 publications

References 10 publications

The Genus Iodidimonas: From Its Discovery to Potential Applications

The Genus Iodidimonas: From Its Discovery to Potential Applications

Microbial involvement in iodine cycle: mechanisms and potential applications

Iodidimonas, a bacterium unable to degrade hydrocarbons, thrives in a bioreactor treating oil and gas produced water

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