A novel endoscopic full-thickness plicator for the treatment of GERD: a pilot study

Chuttani, Ram; Sud, Randhir; Sachdev, G K; Puri, Rajesh; Kozarek, Richard A.; Haber, Gregory B.; Pleskow, Douglas K.; Zaman, M Justin S; Lembo, Anthony

doi:10.1016/s0016-5107(03)02027-3

Cited by 72 publications

(53 citation statements)

References 15 publications

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“…Several studies have reported that these endoscopic techniques may reduce or eliminate PPI consumption in patients who demonstrate only partial response to PPI therapy. [85][86][87] Regardless, the role of endoscopic therapy in GERD has been under close scrutiny in last few years, because of untoward adverse effects and evidence of improvement of subjective parameters only, when compared with sham intervention. Further studies are needed to assess the role of endoscopic therapy in GERD in general and specifically in PPI failure patients.…”

Section: Treatmentmentioning

confidence: 99%

Systematic review: proton‐pump inhibitor failure in gastro‐oesophageal reflux disease – where next?

Fass¹,

Shapiro²,

Dekel³

et al. 2005

Aliment Pharmacol Ther

348

331

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SummaryProton‐pump inhibitor failure has become a common clinical dilemma in gastrointestinal clinics and has been increasingly encountered at the primary care level as well. Underlying mechanisms are diverse and may overlap. Most patients who have proton‐pump inhibitor failure are likely to originate from the non‐erosive reflux disease phenotype. Currently, available diagnostic modalities provide limited clues to the exact underlying cause. Treatment relies primarily on escalating dosing of proton‐pump inhibitors. However, new insights into the pathophysiology of proton‐pump inhibitor failure are likely to provide alternative therapeutic options.

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Section: Treatmentmentioning

confidence: 99%

Systematic review: proton‐pump inhibitor failure in gastro‐oesophageal reflux disease – where next?

Fass¹,

Shapiro²,

Dekel³

et al. 2005

Aliment Pharmacol Ther

348

331

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“…In this initial trial, one full-thickness plication was used. A pilot study on 7 patients also showed similar results but failed to show objective improvement of reflux [37]. Further studies with single vs. multiple plications are anticipated.…”

Section: Selection Criteria For Endoscopic Therapymentioning

confidence: 83%

Endoscopic Therapy for Gastroesophageal Reflux Disease: A Systematic Review

Sgouros¹,

Bergele²

2006

Digestion

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The high prevalence of gastroesophageal reflux disease (GERD) in Western societies has accelerated the need for new modalities of treatment. Currently, medical and surgical therapies are widely accepted among patients and physicians. The minimally invasive treatment revolution, however, has stimulated several new endoscopic techniques for GERD. Up to now, the data is limited and further studies are necessary to compare the advantages and disadvantages of the various endoscopic techniques to medical and laparoscopic management of GERD. This systematic review reports the efficacy and durability of various endoscopic therapies for GERD whilst the potential for widespread use of these techniques is also discussed. Despite the limited number of studies and remarkable differences between various trials, strict criteria were used for the pooled data presented and an effort was made to avoid bias by including only studies that used off-antisecretory medication scoring as baseline and intent to treat.

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“…Plicator device mimics the effects of conventional antireflux surgery by recreating the antireflux barrier, restoring the angle of his and by forming a one-way gastroesopheageal valve. 29 This procedure is free from serious complications and is reasonably tolerated. Another novel endoluminal technique is the endoluminal fundoplication technique.…”

Section: Endoluminal Antireflux Proceduresmentioning

confidence: 99%

What Should be the Approach in the Long-term Management of Patients with Gastroesophageal Reflux Disease?

Solih¹

2013

WJOLS

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A novel endoscopic full-thickness plicator for the treatment of GERD: a pilot study

Cited by 72 publications

References 15 publications

Systematic review: proton‐pump inhibitor failure in gastro‐oesophageal reflux disease – where next?

Systematic review: proton‐pump inhibitor failure in gastro‐oesophageal reflux disease – where next?

Endoscopic Therapy for Gastroesophageal Reflux Disease: A Systematic Review

What Should be the Approach in the Long-term Management of Patients with Gastroesophageal Reflux Disease?

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