A novel endoscopic delivery system for placement of a duodenal-jejunal implant for the treatment of obesity and type 2 diabetes

Fishman, Ezra; Melanson, Dave; Lamport, Ron; Levine, Andy

doi:10.1109/iembs.2008.4649708

Cited by 13 publications

(12 citation statements)

References 7 publications

(6 reference statements)

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“…It will allow ingested foodstuffs to flow through; however, they will not make contact with digestive enzymes until they have passed the distal end of the sleeve [100]. An early randomized control study showed promise for the device, demonstrating a modest short-term weight loss (19 % excess weight loss) compared to control, as well as improvements in fasting glucose and HbA1c albeit only after 3 months of follow-up [101].…”

Section: Medical Devicesmentioning

confidence: 97%

The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

Melvin

Roux

Docherty

2016

Curr Atheroscler Rep

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In addition to the role of gut hormones in the regulation of energy homeostasis, our understanding of the potential influence of enteroendocrine peptides in food reward pathways is evolving. So too is the role of gut derived hormones on energy expenditure. Gut-derived hormones have the ability to alter feeding behavior. Certain obesity therapies already manipulate this system; however, our evolving understanding of the effects of enteroendocrine signals on hedonic aspects of feeding and energy expenditure may be crucial in identifying future obesity therapies.

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Section: Medical Devicesmentioning

confidence: 97%

The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

Melvin

Roux

Docherty

2016

Curr Atheroscler Rep

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“…5) [41]. DJBS consists of a metallic anchor (Nitinol) that attaches the implant to the duodenum bulb and a 60 cm long GI liner that extends from duodenum to the proximal jejunum.…”

Section: Obesitymentioning

confidence: 99%

Endoscopic Accessories Used for More Advanced Endoluminal Therapeutic Procedures

Lee

2017

Clin Endosc

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Endoscopic accessories describe an extensive variety of auxiliary instruments used for diagnostic and therapeutic endoscopy. Various endoscopic accessories have been developed over the previous few decades and are mostly used for treating neoplastic lesions, such as early gastrointestinal (GI) carcinomas and premalignant lesions. Because of extensive research on natural orifice endoluminal surgery (NOTES) in the early 2000s and recent technological developments, new devices have been developed for various advanced endoluminal therapeutic procedures. In particular, a remarkable development of endoscopic management was achieved in the field of gastroesophageal reflux disease (GERD) and obesity. In both conditions, there is treatment gap between medical and surgical therapy. A large proportion of the patients who do not respond to medical treatment and lifestyle modification, still hesitate to directly undergo surgical treatment. To bridge this gap, endoscopic management has been receiving increasing attention. In this article, I review endoscopic and/or endoluminal devices used for the treatment of GERD and obesity with proposed mechanisms of their function.

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“…Pancreatic and bile secretions mix with the undigested nutrients at the distal end of the DJBL. The device is approved for a maximum treatment period of 12 months and is indicated for obese patients with T2DM …”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy and safety of the duodenal‐jejunal bypass liner in obese patients with type 2 diabetes mellitus: A case control study

Laubner

Riedel

Fink

et al. 2018

Diabetes Obesity Metabolism

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A novel endoscopic delivery system for placement of a duodenal-jejunal implant for the treatment of obesity and type 2 diabetes

Cited by 13 publications

References 7 publications

The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

Endoscopic Accessories Used for More Advanced Endoluminal Therapeutic Procedures

Comparative efficacy and safety of the duodenal‐jejunal bypass liner in obese patients with type 2 diabetes mellitus: A case control study

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