A novel Electrospinning Procedure for the Production of Straight Aligned and Winded Fibers

Errico, Cesare; Chiellini, Federica; Detta, Nicola; Piras, Anna Maria; Puppi, Dario; Chiellini, Emo

doi:10.5101/nbe.v3i4.p222-226

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Moreover, different morphological parameters of electrospun fibers assemblies, such as fiber size, inter‐fiber distance and fiber alignment, can be varied by acting on processing parameters (e.g. polymer concentration, flow rate, spinneret inner diameter, applied voltage, distance between spinneret and collector, and auxiliary electrodes) …”

Section: Nano/microfibrous Scaffolds Fabricationmentioning

confidence: 99%

Nano/microfibrous polymeric constructs loaded with bioactive agents and designed for tissue engineering applications: A review

et al. 2014

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Nano/microfibrous polymeric constructs present various inherent advantages, such as highly porous architecture and high surface to volume ratio, making them attractive for tissue engineering purposes. Electrospinning is the most preferred technique for the fabrication of polymeric nanofibrous assemblies that can mimic the physical functions of native extracellular matrix greatly favoring cells attachment and thus influencing their morphology and activities. Different approaches have been developed to apply polymeric microfiber fabrication techniques (e.g. wet-spinning) for the obtainment of scaffolds with a three-dimensional network of micropores suitable for effective cells migration. Progress in additive manufacturing technology has led to the development of complex scaffold's shapes and microfibrous structures with a high degree of automation, good accuracy and reproducibility. Various loading methods, such as direct blending, coaxial electrospinning and microparticles incorporation, are enabling to develop customized strategies for the biofunctionalization of nano/microfibrous scaffolds with a tailored kinetics of release of different bioactive agents, ranging from small molecules, such as antibiotics, to protein drugs, such as growth factors, and even cells. Recent activities on the combination of different processing techniques and loading methods for the obtainment of biofunctionalized polymeric constructs with a complex multiscale structure open new possibilities for the development of biomimetic scaffolds endowed with a hierarchical architecture and a sophisticated release kinetics of different bioactive agents. This review is aimed at summarizing current advances in technologies and methods for manufacturing nano/microfibrous polymeric constructs suitable as tissue engineering scaffolds, and for their combination with different bioactive agents to promote tissue regeneration and therapeutic effects.

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Section: Nano/microfibrous Scaffolds Fabricationmentioning

confidence: 99%

Nano/microfibrous polymeric constructs loaded with bioactive agents and designed for tissue engineering applications: A review

et al. 2014

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Drug release kinetics of electrospun fibrous systems

Puppi

Chiellini

2018

Core-Shell Nanostructures for Drug Delivery and Theranostics

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A novel method for biopolymer surface nanostructuring by platinum deposition and subsequent thermal annealing

et al. 2012

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A novel procedure for biopolymer surface nanostructuring with defined surface roughness and pattern dimension is presented. The surface properties of sputtered platinum layers on the biocompatible polymer poly(l-lactic acid) (PLLA) are presented. The influence of thermal treatment on surface morphology and electrical resistance and Pt distribution in ca. 100 nm of altered surface is described. The thickness, roughness and morphology of Pt structures were determined by atomic force microscopy. Surface sheet resistance was studied by a two-point technique. It was the sequence of Pt layer sputtering followed by thermal treatment that dramatically changed the structure of the PLLA’s surface. Depending on the Pt thickness, the ripple-like and worm-like patterns appeared on the surface for thinner and thicker Pt layers, respectively. Electrokinetic analysis confirmed the Pt coverage of PLLA and the slightly different behaviour of non-annealed and annealed surfaces. The amount and distribution of platinum on the PLLA is significantly altered by thermal annealing.

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A novel Electrospinning Procedure for the Production of Straight Aligned and Winded Fibers

Cited by 3 publications

References 13 publications

Nano/microfibrous polymeric constructs loaded with bioactive agents and designed for tissue engineering applications: A review

Nano/microfibrous polymeric constructs loaded with bioactive agents and designed for tissue engineering applications: A review

Drug release kinetics of electrospun fibrous systems

A novel method for biopolymer surface nanostructuring by platinum deposition and subsequent thermal annealing

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