A novel electrochemical sensor based on AuPd/UiO-66-NH<sub>2</sub>/GN composites for sensitive dopamine detection

Zhou, Ying; Li, Ruichun; Zhang, Guomei; Zhang, Yan; Zhang, Caihong; Shuang, Shaomin

doi:10.1039/d2an01538b

Cited by 19 publications

(6 citation statements)

References 51 publications

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“…In comparison to previously reported nanomaterial-modi ed dopamine sensors [34][35][36][37][38][39][40] (Table 1), the dopamine sensor fabricated utilizing PVP/rGO-MWCNT not only offers enhanced accuracy in dopamine content detection but also exhibits heightened sensitivity and reduced detection limits. Reproducibility is an important factor affecting the accuracy of DA detection.…”

Section: 7mentioning

confidence: 80%

An ultra-sensitive dopamine electrochemical sensor based on PVP/rGO-MWCNT composites

Jiang,

Luo,

Liu

et al. 2024

Preprint

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Dopamine (DA) is a neurotransmitter secreted by the brain that plays a variety of roles in the central nervous system. An imbalance in dopamine can cause a range of disease symptoms and negative effects, such as Parkinson's disease and arrhythmia. Detecting DA accurately and rapidly is therefore crucial for medical diagnosis and disease prevention. In this study, PVP and rGO-MWCNT were encapsulated using a hydrothermal method to form a composite material. The composite was then characterized using scanning electron microscopy (SEM). The three materials were combined, and based on this, a new DA electrochemical sensor was constructed. It is worth noting that the high specific surface area and high conductivity of rGO-MWCNT cooperate with the amphiphilic and stable dispersion of PVP, which further improves the electrochemical performance of the sensor for DA. Under optimal conditions, DA content is detected within a wide range and with a low detection limit which is explained by the electrochemical redox process of the sensor. In addition, the sensor shows satisfactory recovery and accuracy in detecting DA content in real human serum samples using the standard addition method.

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Section: 7mentioning

confidence: 80%

An ultra-sensitive dopamine electrochemical sensor based on PVP/rGO-MWCNT composites

Jiang,

Luo,

Liu

et al. 2024

Preprint

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“…The UiO-66 structure is characterized by robust connections between non-mineral blocks and organic linkers, a high coordination number, and sturdy O-Zr bonds. Their ability to be adjusted and adapted in both structure and function makes them attractive options for a wide range of uses, such as heterogeneous catalysis, gas adsorption, energy devices, sensing, and medical applications [42][43][44][45][46]. Recent studies indicated that the combination of MOFs with other nanostructures can not only enhance their electrical conductivity but also significantly improve the stability and electro-catalytic ability of modified electrodes [47][48][49].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Nanosensor for the Simultaneous Determination of Anticancer Drugs Epirubicin and Topotecan Using UiO-66-NH2/GO Nanocomposite Modified Electrode

Tajik,

Shams,

Beitollahi

et al. 2024

Biosensors

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In this work, UiO-66-NH2/GO nanocomposite was prepared using a simple solvothermal technique, and its structure and morphology were characterized using field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). An enhanced electrochemical sensor for the detection of epirubicin (EP) was proposed, which utilized a UiO-66-NH2/GO nanocomposite-modified screen-printed graphite electrode (UiO-66-NH2/GO/SPGE). The prepared UiO-66-NH2/GO nanocomposite improved the electrochemical performance of the SPGE towards the redox reaction of EP. Under optimized experimental conditions, this sensor demonstrates a remarkable limit of detection (LOD) of 0.003 µM and a linear dynamic range from 0.008 to 200.0 µM, providing a highly capable platform for sensing EP. Furthermore, the simultaneous electro-catalytic oxidation of EP and topotecan (TP) was investigated at the UiO-66-NH2/GO/SPGE surface utilizing differential pulse voltammetry (DPV). DPV measurements revealed the presence of two distinct oxidation peaks of EP and TP, with a peak potential separation of 200 mV. Finally, the UiO-66-NH2/GO/SPGE sensor was successfully utilized for the quantitative analysis of EP and TP in pharmaceutical injection, yielding highly satisfactory results.

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“…Dopamine equilibrium is vital for the maintenance of physical health and physiological processes . It not only regulates numerous physiological activities but also serves as an indicator for various disease diagnosis . Abnormal levels of DA may lead to various neurological disorders, such as epilepsy, Parkinson’s disease, Alzheimer’s disease, mania, and schizophrenia. − Moreover, DA as an intravenous medication may result in an elevation of blood pressure and heart rate .…”

Section: Introductionmentioning

confidence: 99%

Bovine Serum Albumin Template-Mediated Fabrication of Ruthenium Dioxide/Multiwalled Carbon Nanotubes: High-Performance Electrochemical Dopamine Biosensing in Human Serum

Lei,

Zhao,

Asif

et al. 2024

Langmuir

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The presence of abnormal dopamine (DA) levels may cause serious neurological disorders, therefore, the quantitative analysis of DA and its related research are of great significance for ensuring health. Herein, the bovine serum albumin (BSA) template method has been proposed for the preparation of catalytically high-performance ruthenium dioxide/multiwalled carbon nanotube (RuO2/MWCNT) nanocomposites. The incorporation of MWCNTs has improved the active surface area and conductivity while effectively preventing the aggregation of RuO2 nanoparticles. The outstanding electrocatalytic performance of RuO2/MWCNTs has promoted the electro-oxidation of DA at neutral pH. The electrochemical sensing platform based on RuO2/MWCNTs has demonstrated a wide linear range (0.5 to 111.1 μM), low detection limit (0.167 μM), excellent selectivity, long-term stability, and good reproducibility for DA detection. The satisfactory recovery range of 94.7% to 103% exhibited by the proposed sensing podium in serum samples signifies its potential for analytical applications. The aforementioned results reveal that RuO2/MWCNT nanostructures hold promising aptitude in the electrochemical sensor to detect DA in real samples, further offering broad prospects in clinical and medical diagnosis.

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A novel electrochemical sensor based on AuPd/UiO-66-NH₂/GN composites for sensitive dopamine detection

Abstract: Metal-organic frameworks (MOFs) has emerged as interesting nanomaterials owing to their large surface area, high porosity, tunable pore architecture and easy functionalization. However, its inferior electrical conductivity hinders its application...

Cited by 19 publications

References 51 publications

An ultra-sensitive dopamine electrochemical sensor based on PVP/rGO-MWCNT composites

An ultra-sensitive dopamine electrochemical sensor based on PVP/rGO-MWCNT composites

Electrochemical Nanosensor for the Simultaneous Determination of Anticancer Drugs Epirubicin and Topotecan Using UiO-66-NH2/GO Nanocomposite Modified Electrode

Bovine Serum Albumin Template-Mediated Fabrication of Ruthenium Dioxide/Multiwalled Carbon Nanotubes: High-Performance Electrochemical Dopamine Biosensing in Human Serum

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A novel electrochemical sensor based on AuPd/UiO-66-NH2/GN composites for sensitive dopamine detection

Abstract: Metal-organic frameworks (MOFs) has emerged as interesting nanomaterials owing to their large surface area, high porosity, tunable pore architecture and easy functionalization. However, its inferior electrical conductivity hinders its application...

Cited by 19 publications

References 51 publications

An ultra-sensitive dopamine electrochemical sensor based on PVP/rGO-MWCNT composites

An ultra-sensitive dopamine electrochemical sensor based on PVP/rGO-MWCNT composites

Electrochemical Nanosensor for the Simultaneous Determination of Anticancer Drugs Epirubicin and Topotecan Using UiO-66-NH2/GO Nanocomposite Modified Electrode

Bovine Serum Albumin Template-Mediated Fabrication of Ruthenium Dioxide/Multiwalled Carbon Nanotubes: High-Performance Electrochemical Dopamine Biosensing in Human Serum

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A novel electrochemical sensor based on AuPd/UiO-66-NH₂/GN composites for sensitive dopamine detection