A novel electrochemical immunosensor for carcinoembryonic antigen based on Cu-MOFs-TB/polydopamine nanocarrier

Li, Jianbo; Shang, Yonghui; Xu, Jinqiong; Chen, Yi; Jia, Yarong; Zheng, Jianbin

doi:10.1016/j.jelechem.2020.114563

Cited by 21 publications

(11 citation statements)

References 36 publications

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“…Therefore, quantitative measurements of CEA in biological fluids such as blood and serum are critical for locating, and understanding the prognosis, staging, and recurrence of multiple cancers [ 197 , 198 , 199 , 200 , 201 ]. For electrochemical immunosensor/aptasensor assays, MNP-based probes which have strong biocompatibility and electrical conductivity are of great interest [ 201 , 202 , 203 , 204 , 205 ]. MNPs have superior efficiency as tags or labels for amplifying biomolecular interactions and as the enhancers of electrochemical signals [ 198 , 199 , 200 , 201 , 202 , 203 ].…”

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

“…For electrochemical immunosensor/aptasensor assays, MNP-based probes which have strong biocompatibility and electrical conductivity are of great interest [ 201 , 202 , 203 , 204 , 205 ]. MNPs have superior efficiency as tags or labels for amplifying biomolecular interactions and as the enhancers of electrochemical signals [ 198 , 199 , 200 , 201 , 202 , 203 ]. Depending upon the complexity and necessities, mono/bi/tri-metallic composites are utilized for constructing different types of ECBs with label-free or labeled, sandwich or non-sandwich strategies for CEA immunosensor/aptasensor [ 195 , 196 , 199 , 207 , 210 ].…”

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

“…The authors emphasized that the sensor could be used for the POCT of CEA from human serum. Aside from MNP–carbon material-based composites, metal oxide NPs, core shell MNPs, quantum dot NPs, graphene, MOF, etc., have extensively been studied as the electrode probes for fabricating both labeled or label-free sandwich immunosensing arrays for the ultrasensitive detection of CEA for early-stage cancer diagnoses [ 196 , 202 , 209 , 211 , 212 , 213 , 214 , 215 , 216 ].…”

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

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Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

Section: Mnp-based Ecbs For Biomolecule Detectionmentioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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“…53 In addition, the use of other 1D structural materials as the supporting framework, such as plant fiber, polydopamine nanotubes, etc., has also been proven to be an effective strategy. [54][55][56][57] Electrospinning technology offers another direct and efficient method distinct from chemical synthesis. It is currently a straightforward and effective means of producing nanofibers, with characteristics such as high specific surface area, porosity, and fiber uniformity, finding widespread applications across various fields.…”

Section: Morphology Design and Constructionmentioning

confidence: 99%

Structural and compositional analysis of MOF-derived carbon nanomaterials for the oxygen reduction reaction

Zhang,

Xu,

Zhang

et al. 2024

Chem. Commun.

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“…Liu et al revealed the synthesis of Cu MOFs by a hydrothermal method for establishing a sandwich-type sensor, as shown in Figure 11 [ 47 ]. Toluidine blue (TB)-loaded mesoporous Cu MOFs with PDA coating were employed as a signal transducer probe.…”

Section: Progress In Mof-based Biosensors For the Detection Of Ceamentioning

confidence: 99%

MOF-Based Biosensors for the Detection of Carcinoembryonic Antigen: A Concise Review

Ibrahim

Greish

2023

Molecules

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Cancer has been considered one of the most serious diseases in recent decades. Early diagnosis of cancer is a crucial step for expedited treatment. Ideally, detection of cancer biomarkers, which are usually elevated because of cancer, is the most straightforward approach to detecting cancer. Among these biomarkers, the carcinoembryonic antigen (CEA) is considered one of the most important tumor markers for colorectal cancer. The CEA has also been recognized as a biomarker for other types of cancers, including breast, gastric, ovarian, pancreatic, and lung cancers. Typically, conventional CEA testing depends on immunoassay approaches, which are known to be complex, highly expensive, and time consuming. Accordingly, various types of biosensors have been designed for the detection of cancer biomarkers. The main prerequisites of these biosensors are high sensitivity, fast response, and low cost. Many nanostructures have been involved in the design of biosensors, such as nanoparticles of certain metals and metal oxides that are further functionalized to contribute to the sensing of the biomarkers. Alternatively, metal organic frameworks (MOFs), which are extended crystalline structures comprising metal clusters surrounded by organic linkers, have been shown to be highly promising for the development of biosensors. The 3D structure of MOFs results in a combination of high surface area and high interconnected porosity, which are believed to facilitate their function in the design of a biosensor. This review briefly classifies and describes MOF-based biosensor trials that have been published recently for the aim of detecting CEA.

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A novel electrochemical immunosensor for carcinoembryonic antigen based on Cu-MOFs-TB/polydopamine nanocarrier

Cited by 21 publications

References 36 publications

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Structural and compositional analysis of MOF-derived carbon nanomaterials for the oxygen reduction reaction

MOF-Based Biosensors for the Detection of Carcinoembryonic Antigen: A Concise Review

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