A novel electroanalytical nanosensor based on MWCNT/Fe2O3 nanoparticles for the determination of antiparkinson drug ropinirole

Abstract

A carbon paste electrode modified by -COOH functionalized multiwalled carbon nanotubes and Fe 2 O 3 nanoparticles was prepared for the determination of antiparkinson drug ropinirole using adsorptive stripping differential pulse and square wave voltammetric methods. The results showed that the modified electrode significantly enhanced the oxidation peak current of ropinirole. Effects of pH, scan rate, and electrolyte type on the determination of ropinirole were analyzed. Ropinirole gave two irreversible anodic peaks at modified electrode in pH 6.0 phosphate buffer solution; studies were realized for the peak which was more positive potential (peak 2). Limit of detection values were 1.30×10 −3 μg mL −1 and 4.08×10 −4 μg mL −1 for peak 2 with adsorptive stripping differential pulse and square wave voltammetric methods, respectively. The proposed methods were applied to analysis of pharmaceutical dosage form containing ropinirole. The recovery studies with values of 105.50 and 100.88 % showed the accuracy of these methods. The number of transferred electrons was investigated.

Voltammetric behaviors of an emerging pollutant benzotriazole on multiwall carbon nanotubes (MWNTs)—Nafion modified electrode in various pH mediums

“…There is a linear relationship between the peak current and the square root of scan rate (v 1/2 ) in the range from 10 to 150 mV s −1 (inset (a) of Fig. 5), demonstrating that the process of BTA transfer to the MWNTs-Nafion/GCE surface is diffusion controlled and irreversible [29], and the importance of the rate-determining step in the reduction reaction. The linear regression equation is expressed as −i/ 10 −4 A = −1.98 + 0.997v 1/2 /(mV s −1 ) 1/2 (r = 0.996).…”

Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode

“…Its oral bioavailability is approximately 55%, and the peak serum concentration occurs between 3 and 8 hours (3). Electrochemical methods, particularly voltammetry, are frequently preferred because they are simple, cheap, sensitive and reliable; also, their short analysis time makes them more popular (4). Carbon-based materials are commonly used as electrode materials in voltammetric studies because they match the specifications of an ideal electrode material, which is expected to be stable over time, have low residual current and a wide potential range (5).…”

Voltammetric Determination of Vardenafil on Modified Electrodes Constructed by Graphite, Metal Oxides and Functionalized Multi-Walled Carbon Nanotubes

“…Among these are their low operational cost, higher selectivity and sensitivity, higher accuracy and consistency as NH 2 -MWCNT/ZnO/GPE well as easier use and the ability of miniaturization. [3][4][5][6] The sensitivity and selectivity of the electrochemical quantification depend on various factors, but the most important and vital of them are the electrodes used. Up to now, several methods were recommended for the determination of vardenafil such as atomic emission spectroscopy, 7 liquid chromatography with UV detection, [8][9][10] fluorescence detection, 11 chemiluminescence detection, 12 tandem mass spectrometry, [13][14] gas chromatography/mass spectrometry 15 and voltammetry.…”

“…Similar to ZnO nanoparticles, CNTs also have a good biocompatibility which makes them preferable in biosensing applications. 4,25 In this work, two voltammetric techniques (SWSV and DPSV) were suggested for sensitive determination of vardenafil using modified electrode based on graphite, metal oxide (ZnO) and -NH 2 functionalized multi-walled carbon nanotubes. The proposed modified electrode has remarkable advantages such as in terms of simplicity of paste preparation, low cost, easy surface renewal, fairly good stability, low residual current, easy portability and miniaturization.…”