A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

Gao, Long; Zhou, Yanling; Peng, Jinliang; Xu, Chen; Xu, Qing; Xing, Min; Chang, Jiang

doi:10.1038/s41427-019-0168-0

Cited by 122 publications

(84 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Here, we investigated the effects on the freezing temperature of hydrogels. Hydrogels are cross-linked hydrophilic polymers, swollen by large amounts of water, which have wide applications for tissue engineering and drug delivery and cryopreservation [27][28][29]. Inspired by adhesive proteins in mussels [30,31], the highly hydrophilic polysaccharide sodium alginate (SA) is attached onto substrates, forming hydrogel coatings.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels as Durable Anti-Icing Coatings Inhibit and Delay Ice Nucleation

et al. 2020

View full text Add to dashboard Cite

The accumulation of ice on surfaces brings dangerous and costly problems to our daily life. Thus, it would be desirable to design anti-icing coatings for various surfaces. We report a durable anti-icing coating based on mussel-inspired chemistry, which is enabled via fabricating a liquid water layer, achieved by modifying solid substrates with the highly water absorbing property of sodium alginate. Dopamine, the main component of the mussel adhesive protein, is introduced to anchor the sodium alginate in order to render the coating applicable to all types of solid surfaces. Simultaneously, it serves as the cross-linking agent for sodium alginate; thus, the cross-linking degree of the coatings could be easily varied. The non-freezable and freezable water in the coatings with different cross-link degrees all remain liquid-like at subzero conditions and synergistically fulfill the aim of decreasing the temperature of ice nucleation. These anti-icing coatings display excellent stability even under harsh conditions. Furthermore, these coatings can be applied to almost all types of solid surfaces and have great promise in practical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Hydrogels as Durable Anti-Icing Coatings Inhibit and Delay Ice Nucleation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The trend seen here was similar to the results published by Yu et al, who similarly fabricated Si-incorporated GelMa and tested its potential in regeneration of tissue defects [ 34 ]. In addition, Gao et al fabricated a dual Si-incorporated sodium alginate hydrogel and showed that this hydrogel could promote in vivo wound healing as compared to a placebo [ 26 ]. It was shown in their study that the rapid ion exchanges on the surfaces of Si-GelMa hydrogels make the micro-environment alkaline, thus enhancing tissue–hydrogel interaction and integration.…”

Section: Resultsmentioning

confidence: 99%

“…The growth factors not only contribute to the attraction between endothelial cell and fibroblasts but also enhance the secretion of extracellular matrix (ECM)-related proteins from these cells [ 25 ]. Furthermore, it had been previously reported that BG can release calcium ions gradually, which may contribute to the better adhesion of hydrogels with native tissues in subsequent chelation reactions [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Calcium Silicate-Activated Gelatin Methacrylate Hydrogel for Accelerating Human Dermal Fibroblast Proliferation and Differentiation

Lin

Lee

et al. 2020

Polymers

View full text Add to dashboard Cite

Wound healing is a complex process that requires specific interactions between multiple cells such as fibroblasts, mesenchymal, endothelial, and neural stem cells. Recent studies have shown that calcium silicate (CS)-based biomaterials can enhance the secretion of growth factors from fibroblasts, which further increased wound healing and skin regeneration. In addition, gelatin methacrylate (GelMa) is a compatible biomaterial that is commonly used in tissue engineering. However, it has low mechanical properties, thus restricting its fullest potential for clinical applications. In this study, we infused Si ions into GelMa hydrogel and assessed for its feasibility for skin regeneration applications by observing for its influences on human dermal fibroblasts (hDF). Initial studies showed that Si could be successfully incorporated into GelMa, and printability was not affected. The degradability of Si-GelMa was approximately 20% slower than GelMa hydrogels, thus allowing for better wound healing and regeneration. Furthermore, Si-GelMa enhanced cellular adhesion and proliferation, therefore leading to the increased secretion of collagen I other important extracellular matrix (ECM) remodeling-related proteins including Ki67, MMP9, and decorin. This study showed that the Si-GelMa hydrogels were able to enhance the activity of hDF due to the gradual release of Si ions, thus making it a potential candidate for future skin regeneration clinical applications.

show abstract

“…Hydrogels, similar to the ECM, have been widely studied and used in cartilage tissue engineering. [ 4,5 ] Cartilaginous ECM is mainly composed of natural polymers such as collagen and proteoglycans. [ 6 ] Gelatin (Gel) is a denatured product from collagen.…”

Section: Introductionmentioning

confidence: 99%

A Biomimetic Hybrid Hydrogel Based on the Interactions between Amino Hydroxyapatite and Gelatin/Gellan Gum

Wang

et al. 2020

Macro Materials & Eng

View full text Add to dashboard Cite

In this work, a gelatin (Gel)‐oxidized gellan gum (OG)/amino hydroxyapatite (mHap) hybrid hydrogel with Schiff base linkages is reported. The mHap is obtained by modifying hydroxyapatite with tetraethyl orthosilicate and 3‐aminopropyl‐triethoxysilane. The effects of different mHap contents on the structure, morphology, and properties of hydrogels are particularly investigated. Scanning electron microscopy coupled with energy dispersion spectroscopy reveals that mHap of around 100 nm is uniformly distributed inside the hydrogel with interconnected porous structures. Notably, the hydrogel with 1 wt% mHap possesses the highest compressive stress (2.01 ± 0.10 MPa) at 90% strain, as well as the lowest equilibrium swelling ratio (97% ± 5%) and degradation rate than other hydrogels. Besides, an ultra‐high compressive stress equivalent to 91% of the initial stress can be obtained by this hydrogel after 50 loading‐unloading cycles (85% strain). Meanwhile, after being swollen, this improved hydrogel also exhibits better structural stability than Gel‐OG hydrogel. The in vitro 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay further shows that all hydrogels are nontoxic against mouse fibroblasts. This work provides a biomimetic strategy to construct the organic/inorganic hydrogels with excellent interactions, elasticity, reversibility, and biocompatibility, which is of great importance for the practical applications in cartilage tissue engineering.

show abstract

A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

Cited by 122 publications

References 38 publications

Hydrogels as Durable Anti-Icing Coatings Inhibit and Delay Ice Nucleation

Hydrogels as Durable Anti-Icing Coatings Inhibit and Delay Ice Nucleation

Calcium Silicate-Activated Gelatin Methacrylate Hydrogel for Accelerating Human Dermal Fibroblast Proliferation and Differentiation

A Biomimetic Hybrid Hydrogel Based on the Interactions between Amino Hydroxyapatite and Gelatin/Gellan Gum

Contact Info

Product

Resources

About