A novel droplet-based approach to study phase transformations in lyotropic liquid crystalline systems

He, Vincent; Cadarso, Víctor J.; Seibt, Susanne; Boyd, Ben J.; Neild, Adrian

doi:10.1016/j.jcis.2023.03.011

Cited by 5 publications

(4 citation statements)

References 61 publications

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“…71,72 This approach offers a more comprehensive understanding of the nucleation and growth mechanisms involved in the formation of NPs within confined geometries. 73 Overall, miniaturization of the NPs synthesis process offers several advantages, as presented in Figure 1. For instance, microfluidic devices allow improving mixing and speeding up chemical reactions that take place in the micrometric channels, which leads to the generation of homogeneous NPs.…”

Section: Microfluidic Devicesmentioning

confidence: 99%

“…Furthermore, microfluidics advances have facilitated in situ NPs characterization by seamlessly integrating advanced analysis techniques, such as synchrotron small-angle X-ray scattering (SAXS) . This emerging application involves the combination of specially designed microfluidic devices with SAXS, creating a platform that allows for real-time detection of dynamic structural changes during the production of NPs. , This approach offers a more comprehensive understanding of the nucleation and growth mechanisms involved in the formation of NPs within confined geometries . Overall, miniaturization of the NPs synthesis process offers several advantages, as presented in Figure .…”

Section: Microfluidic Devicesmentioning

confidence: 99%

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Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Gimondi,

Ferreira,

Reis

et al. 2023

ACS Nano

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The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of diseases for which conventional therapies present serious limitations. Additionally, NPs can drastically improve early diagnosis and follow-up of many disorders. However, to harness their full capabilities, they must be precisely designed, produced, and tested in relevant models. Microfluidic systems can simulate dynamic fluid flows, gradients, specific microenvironments, and multiorgan complexes, providing an efficient and cost-effective approach for both NPs synthesis and screening. Microfluidic technologies allow for the synthesis of NPs under controlled conditions, enhancing batch-to-batch reproducibility. Moreover, due to the versatility of microfluidic devices, it is possible to generate and customize endless platforms for rapid and efficient in vitro and in vivo screening of NPs’ performance. Indeed, microfluidic devices show great potential as advanced systems for small organism manipulation and immobilization. In this review, first we summarize the major microfluidic platforms that allow for controlled NPs synthesis. Next, we will discuss the most innovative microfluidic platforms that enable mimicking in vitro environments as well as give insights into organism-on-a-chip and their promising application for NPs screening. We conclude this review with a critical assessment of the current challenges and possible future directions of microfluidic systems in NPs synthesis and screening to impact the field of nanomedicine.

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Section: Microfluidic Devicesmentioning

confidence: 99%

Section: Microfluidic Devicesmentioning

confidence: 99%

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Gimondi,

Ferreira,

Reis

et al. 2023

ACS Nano

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“…Solutions formed with amphiphilic molecules form micelles due to their self-assembly properties, and these micelles form ordered mesophases called lyotropic liquid crystals (LLCs) [1][2][3]. The micelles that come together may have packaging geometries to form cubic, lamellar, and hexagonal structures, depending on the interactions between them [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Polymer Additive on the Lyotropic Lamellar Phase Formed by Surfactants with Different Head Groups

Cukurkent,

MASALCI

2024

Preprint

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In this study, the effect of polyvinylpyrrolidone (PVP) polymer on lyotropic lamellar phases obtained using different types of surfactants, anionic and cationic, was compared. Three different methods were used to make these comparisons. The polarized microscope (POM) method was used to observe and compare morphological changes. It was observed that the texture structures of the lyotropic lamellae phases obtained by using anionic and cationic surfactants were different from each other. Structural changes were investigated by the small-angle X-ray scattering (SAXS) method. As the polymer concentration added to the lyotropic lamellae phase(s) increased, it was determined that the structural changes of the anionic and cationic samples were different from each other. The interactions of surfactant-polymer molecules with each other and their packaging were accordingly investigated by Fourier transform infrared spectroscopy (FTIR). How the polymer was added to the lyotropic lamellae phase and how the surfactant interacted with the chain and head groups was determined by examining the frequency shifts of the methylene chains and head groups. These frequency shifts provide information about trans-gauche transformations. Both polymers and lyotropic lamellae phases have wide biological and technological uses. For this reason, their use together, that is, the interactions of polymer doped-lamellar phases, is interesting and should be understood.

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“…As compared with thermotropic liquid crystals, the advantages of microfluidics for characterizing the behavior of lyotropic liquid crystals also attracted attention in the last decade [32,33]. Related research activities are more fundamental and recent and are mostly represented by publications of the last several years [34][35][36][37][38][39], where authors discussed the general aspects of orientation and the phase behavior of confined LLC systems. An interesting feature of LLC in microchannels is that they can be convenient models of biological anisotropic liquids in living capillary systems [40,41].…”

Section: Introductionmentioning

confidence: 99%

Molecular Orientation Behavior of Lyotropic Liquid Crystal–Carbon Dot Hybrids in Microfluidic Confinement

Bezrukov,

Galeeva,

Krupin

et al. 2024

IJMS

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Lyotropic liquid crystals represent an important class of anisotropic colloid systems. Their integration with optically active nanoparticles can provide us with responsive luminescent media that offer new fundamental and applied solutions for biomedicine. This paper analyzes the molecular-level behavior of such composites represented by tetraethylene glycol monododecyl ether and nanoscale carbon dots in microfluidic channels. Microfluidic confinement allows for simultaneously applying multiple factors, such as flow dynamics, wall effects, and temperature, for the precise control of the molecular arrangement in such composites and their resulting optical properties. The microfluidic behavior of composites was characterized by a set of analytical and modeling tools such as polarized and fluorescent microscopy, dynamic light scattering, and fluorescent spectroscopy, as well as image processing in Matlab. The composites were shown to form tunable anisotropic intermolecular structures in microchannels with several levels of molecular ordering. A predominant lamellar structure of the composites was found to undergo additional ordering with respect to the microchannel axis and walls. Such an alignment was controlled by applying shear and temperature factors to the microfluidic environment. The revealed molecular behavior of the composite may contribute to the synthesis of hybrid organized media capable of polarized luminescence for on-chip diagnostics and biomimetics.

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A novel droplet-based approach to study phase transformations in lyotropic liquid crystalline systems

Cited by 5 publications

References 61 publications

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Investigation of the Polymer Additive on the Lyotropic Lamellar Phase Formed by Surfactants with Different Head Groups

Molecular Orientation Behavior of Lyotropic Liquid Crystal–Carbon Dot Hybrids in Microfluidic Confinement

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