volume 32, issue 44, P11802-11809 1993
DOI: 10.1021/bi00095a008
View full text
|
|
Share
Keliang Liu, H. Todd Miles, Joe Frazier, V. Sasisekharan

Abstract: We show here for the first time that a stable parallel double helix with Hoogsteen pairing can exist independently of the triple helix of which it is a component part. The experiments employ DNA oligonucleotides with mixed sequences of normal bases. These duplexes are distinct from previously reported ribopolynucleotide helices containing bulky substituents which prevent Watson-Crick pairing as well as from parallel duplexes with Donohue, or reversed Watson-Crick, pairing. Stoichiometry is established by mixin…

expand abstract