A novel discharge risk model for patients hospitalised for acute decompensated heart failure incorporating N-terminal pro-B-type natriuretic peptide levels: a European coLlaboration on Acute decompeNsated Heart Failure: ÉLAN-HF Score

Abstract

In patients hospitalised for ADHF, the addition of the discharge NT-proBNP values as well as the change in NT-proBNP to known risk markers, generates a relatively simple yet robust discharge risk score that importantly improves the prediction of adverse events.

Competing Risk of Cardiac Status and Renal Function During Hospitalization for Acute Decompensated Heart Failure

“…However, when renal function declines more severely (sWRF: increase in creatinine of >0.5 mg/dl in combination with >25% increase in serum creatinine level between admission and discharge), 180-day mortality is significantly increased with 10%. As shown in previous studies, a decrease of more than 30% in NT-proBNP was associated with a 15% absolute lower mortality (20,22,23).…”

“…High levels of NT-proBNP and BNP predicts adverse events after discharge, while lower levels of NT-proBNP or BNP are related to better cardiac status and left ventricular (LV) function and outcome (20)(21)(22)(23).…”

Rationale and design of the ICON-RELOADED study: International Collaborative of N-terminal pro–B-type Natriuretic Peptide Re-evaluation of Acute Diagnostic Cut-Offs in the Emergency Department

“…18 M A N U S C R I P T ACCEPTED MANUSCRIPT 22 of ultrafiltration, hemofiltration, or dialysis that is specifically directed at treatment of heart failure…”

Cardio-renal syndrome

“…When renal function declines more severely (increase in creatinine of >0.5 mg/dL in combination with >25% increase in serum creatinine level between admission and discharge), 180-day mortality is significantly increased by 10%. Relief of congestion in acute HF with a decrease in N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels by more than 30% is associated with a 15% absolute lower mortality 11, 12 .…”