A novel dicationic ionic liquids encompassing pyridinium hydrazone-phenoxy conjugates as antimicrobial agents targeting diverse high resistant microbial strains

Rezki, Nadjet; Al‐Sodies, Salsabeel A.; Ahmed, Hany E. A.; Ihmaid, Saleh; Messali, Mouslim; Ahmed, Sahar; Aouad, Mohamed Reda

doi:10.1016/j.molliq.2019.04.010

Cited by 30 publications

(26 citation statements)

References 36 publications

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“…All the ILs were completely soluble in methanol. Some of the ILs were soluble in water (1-4), isopropanol (3)(4)(5)(6)(7)(8) and acetone (1)(2)(3)(4)(5)(6). The synthesized ILs were insoluble in DMSO, acetonitrile, ethyl acetate, chloroform, toluene and hexane.…”

Section: Resultsmentioning

confidence: 99%

“…Some of the obtained ILs were characterized by very good deterrent properties and effectively limited the feeding of such globally important storage pests as the granary weevil (1,(3)(4)(5)(6)(7)(8) and khapra beetle (5)(6)(7)(8). The mentioned insects belong to two taxonomically distant super-families: Curculionoidea (weevils) and Bostrichoidea (khapra beetle).…”

Section: Resultsmentioning

confidence: 99%

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Third-generation ionic liquids with N-alkylated 1,4-diazabicyclo[2.2.2]octane cations and pelargonate anions

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Third-generation ionic liquids with N-alkylated 1,4-diazabicyclo[2.2.2]octane cations and pelargonate anions

et al. 2020

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“…A number of dicationic ILs have been tested for their antimicrobial activity (see Figure 30, Table 5, and Table S3 for several examples) [90,[136][137][138][139]. The high bactericidal activity of some of these ILs (in particular, nitro-substituted imidazolium salts) suggests their possible medical applications (see Table 5).…”

Section: Dicationic Ionic Liquidsmentioning

confidence: 99%

Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

Vereshchagin

Frolov

Egorova

et al. 2021

IJMS

152

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Quaternary ammonium compounds (QACs) belong to a well-known class of cationic biocides with a broad spectrum of antimicrobial activity. They are used as essential components in surfactants, personal hygiene products, cosmetics, softeners, dyes, biological dyes, antiseptics, and disinfectants. Simple but varied in their structure, QACs are divided into several subclasses: Mono-, bis-, multi-, and poly-derivatives. Since the beginning of the 20th century, a significant amount of work has been dedicated to the advancement of this class of biocides. Thus, more than 700 articles on QACs were published only in 2020, according to the modern literature. The structural variability and diverse biological activity of ionic liquids (ILs) make them highly prospective for developing new types of biocides. QACs and ILs bear a common key element in the molecular structure–quaternary positively charged nitrogen atoms within a cyclic or acyclic structural framework. The state-of-the-art research level and paramount demand in modern society recall the rapid development of a new generation of tunable antimicrobials. This review focuses on the main QACs exhibiting antimicrobial and antifungal properties, commercial products based on QACs, and the latest discoveries in QACs and ILs connected with biocide development.

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“…Cations with a longer alkyl chain (longer than octyl) possessed considerable antimicrobial activity against pathogenic microorganisms, enabling them to function as potent disinfectants. [58,59] Another factor that influences the interaction between an ionic liquid and the membrane lipid bilayer is molecular size. The latter is a function of chain length.…”

Section: Cytotoxicitymentioning

confidence: 99%

Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Nikfarjam

Ghomi

Agarwal

et al. 2021

Adv Funct Materials

148

120

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Excessive and unwarranted administration of antibiotics has invigorated the evolution of multidrug-resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short-lived ion-pair structures are highly tunable and have diverse applications. Apart from their unique physicochemical features, the newly discovered biological activities of ionic liquids have fascinated biochemists, microbiologists, and medical scientists. In particular, their antimicrobial properties have opened new vistas in overcoming the current challenges associated with combating antibioticresistant pathogens. Discussions regarding ionic liquid derivatives in monomeric and polymeric forms with antimicrobial activities are presented here. The antimicrobial mechanism of ionic liquids and parameters that affect their antimicrobial activities, such as chain length, cation/anion type, cation density, and polymerization, are considered. The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionic liquids.

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A novel dicationic ionic liquids encompassing pyridinium hydrazone-phenoxy conjugates as antimicrobial agents targeting diverse high resistant microbial strains

Cited by 30 publications

References 36 publications

Third-generation ionic liquids with N-alkylated 1,4-diazabicyclo[2.2.2]octane cations and pelargonate anions

Third-generation ionic liquids with N-alkylated 1,4-diazabicyclo[2.2.2]octane cations and pelargonate anions

Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

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