A Novel Diamond Microprobe for Neuro-Chemical and -Electrical Recording in Neural Prosthesis

Chan, Ho Yin; Aslam, D.M.; Wiler, James A.; Casey, B.E.

doi:10.1109/jmems.2009.2015493

Cited by 54 publications

(5 citation statements)

References 45 publications

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“…As a result, the CIC values are 526 μC cm –2 and 215 μC cm –2 for TiD 50 and TiD 30 , respectively. These values are very high and comparable to other diamond electrodes, such as the N-UNCD electrodes with a CIC value of 1 mC cm –2 and the iridium oxide electrode with a charge value of 4 mC cm –2 , − as presented in Table .…”

Section: Resultssupporting

confidence: 81%

Single-Step Fabrication Method toward 3D Printing Composite Diamond–Titanium Interfaces for Neural Applications

Mani

Ahnood

Peng

et al. 2021

ACS Appl. Mater. Interfaces

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Owing to several key attributes, diamond is an attractive candidate material for neural interfacing electrodes. The emergence of additivemanufacturing (AM) of diamond-based materials has addressed multiple challenges associated with the fabrication of diamond electrodes using the conventional chemical vapor deposition (CVD) approach. Unlike the CVD approach, AM methods have enabled the deposition of three-dimensional diamond-based material at room temperature. This work demonstrates the feasibility of using laser metal deposition to fabricate diamond−titanium hybrid electrodes for neuronal interfacing. In addition to exhibiting a high electrochemical capacitance of 1.1 mF cm −2 and a low electrochemical impedance of 1 kΩ cm 2 at 1 kHz in physiological saline, these electrodes exhibit a high degree of biocompatibility assessed in vitro using cortical neurons. Furthermore, surface characterization methods show the presence of an oxygenrich mixed-phase diamond−titanium surface along the grain boundaries. Overall, we demonstrated that our unique approach facilitates printing biocompatible titanium−diamond site-specific coating-free conductive hybrid surfaces using AM, which paves the way to printing customized electrodes and interfacing implantable medical devices.

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Section: Resultssupporting

confidence: 81%

Single-Step Fabrication Method toward 3D Printing Composite Diamond–Titanium Interfaces for Neural Applications

Mani

Ahnood

Peng

et al. 2021

ACS Appl. Mater. Interfaces

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show abstract

“…NDs: ND particles and thin-films have found applications in neurosciences as substrates for neuronal growth [ 125 – 127 ] and as microelectrode material [ 128 – 129 ], by virtue of their peculiar electrical and chemical properties and stability. Specht et al [ 125 ] were among the first to report on the suitability of ND as a substrate material.…”

Section: Reviewmentioning

confidence: 99%

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Monaco¹,

Giugliano²

2014

Beilstein J. Nanotechnol.

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SummaryThe search for advanced biomimetic materials that are capable of offering a scaffold for biological tissues during regeneration or of electrically connecting artificial devices with cellular structures to restore damaged brain functions is at the forefront of interdisciplinary research in materials science. Bioactive nanoparticles for drug delivery, substrates for nerve regeneration and active guidance, as well as supramolecular architectures mimicking the extracellular environment to reduce inflammatory responses in brain implants, are within reach thanks to the advancements in nanotechnology. In particular, carbon-based nanostructured materials, such as graphene, carbon nanotubes (CNTs) and nanodiamonds (NDs), have demonstrated to be highly promising materials for designing and fabricating nanoelectrodes and substrates for cell growth, by virtue of their peerless optical, electrical, thermal, and mechanical properties. In this review we discuss the state-of-the-art in the applications of nanomaterials in biological and biomedical fields, with a particular emphasis on neuroengineering.

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“…Boron doped diamond (BDD) has also been considered for long for neural interfacing, firstly for neurotransmitters detection since BDD is a very efficient electrode for analytical chemistry [15][16][17], and then for electrical sensing of cell activities [18,19]. Nitrogen-doped Ultrananocrystalline diamond electrode for retinal interfaces were developed and showed very promising result on rigid implants [20].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Monitoring the evolution of boron doped porous diamond electrode on flexible retinal implant by OCT and in vivo impedance spectroscopy

Hébert

Cottance

Dégardin

et al. 2016

Materials Science and Engineering: C

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A Novel Diamond Microprobe for Neuro-Chemical and -Electrical Recording in Neural Prosthesis

Cited by 54 publications

References 45 publications

Single-Step Fabrication Method toward 3D Printing Composite Diamond–Titanium Interfaces for Neural Applications

Single-Step Fabrication Method toward 3D Printing Composite Diamond–Titanium Interfaces for Neural Applications

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Monitoring the evolution of boron doped porous diamond electrode on flexible retinal implant by OCT and in vivo impedance spectroscopy

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