A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking

Yao, Runhong; Nishii, Kazuhiro; Kito, Takumi; Teranishi, Toshio; Sugiyama, Tomohisa; Sakai, Kazuyoshi; Matsubara, Mamoru; Yamada, Kouji

doi:10.2535/ofaj.96.13

Cited by 7 publications

(8 citation statements)

References 24 publications

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“…Infrasound has been linked to several health problems, namely cardiovascular diseases, sleep disorders, behavioural and cognitive problems [11]. Vibrations alter the function of osteoblasts and osteoclasts, reducing bone resorption and stimulating bone growth [12]. Additionally, this form of stimulation appears to stimulate bone remodelling, implying it has an effect on bone mineralization [13].…”

Section: Discussionmentioning

confidence: 99%

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Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Zagalo¹,

Pereira²,

Casal³

et al. 2022

Preprint

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Introduction: The concentrations of some chemical elements may differ between healthy and diseased tissues. The knowledge of these differences is pivotal to understand the metabolic processes involved in both physiological and diseased states. The aim of this study was to evaluate the elemental composition of calcium (Ca) and phosphorus (P) in the bone of rats subjected to glucose intolerance and/or infrasound.Materials and Methods: X-ray fluorescence spectroscopy was applied in the concentration determination of Ca and P in samples of Wistar rat tibiae. Tibiae from glucose intolerant, non-intolerant, exposed and non-exposed to infrasound rats were analysed.Results: There was a significant decrease in bone P concentration in glucose intolerant rats compared to non-intolerant animals. Similarly, the Ca/P ratio was higher in glucose intolerant animals. There were no significant differences for bone Ca concentration in both studied groups, nor between animals exposed and non-exposed to infrasound in either studied element.Discussion and Conclusions: Glucose intolerant rats had lower bone P concentration and unaltered bone Ca concentration compared to non-glucose intolerant rats. Infrasound exposure was not associated to changes of bone Ca or P. The reduction of bone P concentration may be associated with the augmented risk of bone fractures in diabetes.

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Section: Discussionmentioning

confidence: 99%

“…Osteoblasts and osteoclasts functioning are affected by vibrations, suppressing bone resorption, and encouraging bone formation [12]. Furthermore, bone remodelling is apparently promoted by this type of stimulation, which indicates that it has an impact on bone mineralization [13].…”

Section: Introductionmentioning

confidence: 99%

Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Zagalo¹,

Pereira²,

Casal³

et al. 2022

Preprint

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“…Furthermore, 10 weeks of treadmill training was found to increase the dendritic arbor of the amygdala and hippocampus and enhance amygdala- and hippocampus-associated neuronal function in mice [11]. Taking into account the physiological characteristics of elderly individuals, a laboratory-designed shaking exercise has been developed and shown to be a safe and convenient method of physical exercise [12-14]. The shaking exercise focuses on increasing physical activity by increasing muscle contraction.…”

Section: Introductionmentioning

confidence: 99%

“…When the shaking exercise is applied in a mouse model, we can ensure that all mice in the experiment are exposed to the same external force from a 360° stimulation, thereby ensuring the objectivity of the experiment. Through experiments on mice, previous studies have proven that the shaking exercise can prevent a decline in lumbar [12] and thigh-bone mineral density [14], delaying the onset of arthritis [13] and slowing its progress.…”

Section: Introductionmentioning

confidence: 99%

Maintenance of the Amygdala-Hippocampal Circuit Function with Safe and Feasible Shaking Exercise Therapy in SAMP-10 Mice

Yao¹,

Nishii²,

Aizu³

et al. 2021

Dement Geriatr Cogn Disord Extra

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Introduction: Patients with dementia show reduced adaptive, behavioral, and physiological responses to environmental threats. Physical exercise is expected to delay brain aging, maintain cognitive function and, consequently, help dementia patients face threats and protect themselves skillfully. Methods: To confirm this, we aimed to investigate the effects of the shaking exercise on the avoidance function in the senescence-accelerated mouse-prone strain-10 (SAMP-10) model at the behavioral and tissue levels. SAMP-10 mice were randomized into 2 groups: a control group and a shaking group. The avoidance response (latency) of the mice was evaluated using a passive avoidance task. The degree of amygdala and hippocampal aging was evaluated based on the brain morphology. Subsequently, the association between avoidance response and the degree of amygdala-hippocampal aging was evaluated. Results: Regarding the passive avoidance task, the shaking group showed a longer latency period than the control group (p < 0.05), even and low intensity staining of ubiquitinated protein, and had a higher number of and larger neurons than those of the control group. The difference between the groups was more significant in the BA region of the amygdala and the CA1 region of the hippocampus (staining degree: p < 0.05, neuron size: p < 0.01, neuron counts: p < 0.01) than in other regions. Conclusions: The shaking exercise prevents nonfunctional protein (NFP) accumulation, neuron atrophy, and neuron loss; delays the aging of the amygdala and hippocampus; and maintains the function of the amygdala-hippocampal circuit. It thus enhances emotional processing and cognition functions, the memory of threats, the skillful confrontation of threats, and proper self-protection from danger.

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“…Safe and sustainable muscle activity could help them maintain a healthier metabolism and lifestyle. This work was based on a research-oriented shaking exercise method [5][6][7] in which subjects stand on a horizontal panel. Balance can be quickly achieved on flat surfaces; however, on a rocking medium, the body reacts to maintain balance without falling over.…”

Section: Introductionmentioning

confidence: 99%

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice

Yao

Nishii

Aizu

et al. 2020

Dement Geriatr Cogn Disord

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Introduction: The disabling effects of dementia, an incurable disease with little effect on mortality, affect society far more than many other conditions. Objective: The aim of this study was to stop or delay the onset of dementia using lowcost methods such as physical exercise. Methods: Senescence-accelerated model-prone (SAMP) 10 mice were made to perform a user-friendly shaking exercise for 25 weeks. The motor function and hippocampal functions (learning, spatial cognition) of the mice were evaluated using behavioral experiments. The degree of hippocampal aging was evaluated based on brain morphology. The association between behavioral performance of the mice and the degree of hippocampal aging was then evaluated. Results: The behavioral test results showed that the shaking group had higher motor coordination (p < 0.01) and motor learning (p < 0.05). Significantly higher performances in the learning ability were observed in the shaking group at a middle-period experiment (p < 0.05); the spatial cognitive functions also improved (p < 0.05). The shaking group showed delayed ageing of cells in the dentate gyrus (DG; area: p < 0.01) and cornu Ammonis (CA; area: p < 0.01) regions of the hippocampus. Conclusions: The shaking exercise enhances the activity of mice and reduces age-associated decreases in learning and spatial cognitive functions. Regarding hippocampal morphology, shaking exercise can prevent non-functional protein accumulation, cell atrophy, and cell loss. Specifically, shaking exercise protects cell growth and regeneration in the DG area and enhances the learning function of the hippocampus. Furthermore, shaking exercise maintained the spatial cognitive function of cells in the CA3 and CA1 regions, and prevented the chronic loss of CA2 transmission that decreased the spatial memory decline in mice.

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A novel device to prevent osteoporosis by promoting bone metabolism using a newly developed double-loading stimulation with vibration and shaking

Cited by 7 publications

References 24 publications

Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Impact of infrasound exposure and glucose intolerance on bone composition in Wistar rats

Maintenance of the Amygdala-Hippocampal Circuit Function with Safe and Feasible Shaking Exercise Therapy in SAMP-10 Mice

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice

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