A novel desirability function for multi-response optimization and its application in chemical engineering

Marinković, V.

doi:10.2298/ciceq190715007m

Cited by 10 publications

(14 citation statements)

References 27 publications

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“…However, looking at all the results concurrently, it is evident that the proposed method outperforms the others to some extent. Similar observations were made in thе paper [29].…”

supporting

confidence: 88%

“…Obviously, any type of free-form transformation (exponential, power, logarithmic, logistic) may be employed as a desirability function [5,[24][25][26][27][28][29].…”

Section: Desirability Functionmentioning

confidence: 99%

“…Recently, a novel desirability function for multiresponse optimization was recommended [29], which is a smooth, nonlinear, and differentiable function at target points. This desirability function was defined as:…”

Section: Desirability Functionmentioning

confidence: 99%

“…In this paper, in order to compare the results of previous researches [39], [40], [41], and those obtained by using the novel desirability method [29], the original experiment and all the same conditions were utilized.…”

Section: Examplementioning

confidence: 99%

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Some applications of a novel desirability function in simultaneous optimization of multiple responses

Marinković¹

2021

FME Transactions

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In the framework of multi-response optimization techniques, the optimization methodology based on the desirability function is one of the most popular and most frequently used methodologies by researchers and practitioners in engineering, chemistry, technology and many other fields of science and technique. Numerous desirability functions have been introduced to improve the performance of this optimization methodology. Recently, a novel desirability function for multi-response optimization is proposed, which is smooth, nonlinear, and differentiable, and thus more suitable for applying some of the more efficient gradient-based optimization methods. This paper evaluates the performance of the proposed method through six real examples. After a comparative analysis of the results, it is shown that the proposed method in a certain measure outperforms the other competitive optimization methods.

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“…However, looking at all the results concurrently, it is evident that the proposed method outperforms the others to some extent. Similar observations were made in thе paper [29].…”

supporting

confidence: 88%

“…Obviously, any type of free-form transformation (exponential, power, logarithmic, logistic) may be employed as a desirability function [5,[24][25][26][27][28][29].…”

Section: Desirability Functionmentioning

confidence: 99%

Section: Desirability Functionmentioning

confidence: 99%

Section: Examplementioning

confidence: 99%

See 2 more Smart Citations

Some applications of a novel desirability function in simultaneous optimization of multiple responses

Marinković¹

2021

FME Transactions

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“…The previously reported FRAP activity from Croatian propolis ranged between 40 and 1337.22 µmol Fe 2+ /g [54].…”

Section: Effect Of Operating Conditions On Frap-ec 50 Responsementioning

confidence: 86%

Simultaneous Optimization of Extraction Yield, Phenolic Compounds and Antioxidant Activity of Moroccan Propolis Extracts: Improvement of Ultrasound-Assisted Technique Using Response Surface Methodology

et al. 2022

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Propolis has given rise to refreshing interest in recent years in the field of conventional medicine. Its extraction represents an important process that requires optimal conditions, which strongly affect the yield of extraction, total polyphenols, flavonoid content, and radical scavenging capacity markers. The objective of the present study was to optimize the ultrasound-assisted extraction conditions of Moroccan propolis. The studied responses were the extraction yield, total polyphenols, flavonoid contents (TPC, TFC), and antioxidant activity of the extract evaluated by DPPH-IC50 and FRAP-EC50 assays. The response surface methodology (RSM) and specifically the Box–Behnken design (BBD) were used, taking into account three variables: sonication time (min), solvent/propolis ratio (mL/g), and ethanol concentration (%). After the realization of experiments and data analysis, optimal response values were 15.39%, 192 mg GAE/g of propolis,45.15 mg QEq/g, 29.8 µg/mL, and 128.3 µmol Fe2+/g for extraction yield, TPC, TFC, DPPH-IC50, and FRAP-EC50, respectively. Besides, optimal ultrasound extraction conditions were 15 min for sonication time, 30 mL/g for solvent/propolis ratio, and 40% for ethanol concentration. All obtained experimental values were in good agreement with the predicted values, suggesting that using an experimental design in the ultrasound-assisted extraction process and optimization was prudently chosen.

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Design of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity

Assaggaf,

Jeddi,

Mrabti

et al. 2024

Sci Rep

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The development of novel antioxidant compounds with high efficacy and low toxicity is of utmost importance in the medicine and food industries. Moreover, with increasing concerns about the safety of synthetic components, scientists are beginning to search for natural sources of antioxidants, especially essential oils (EOs). The combination of EOs may produce a higher scavenging profile than a single oil due to better chemical diversity in the mixture. Therefore, this exploratory study aims to assess the antioxidant activity of three EOs extracted from Cymbopogon flexuosus, Carum carvi, and Acorus calamus in individual and combined forms using the augmented-simplex design methodology. The in vitro antioxidant assays were performed using DPPH and ABTS radical scavenging approaches. The results of the Chromatography Gas-Mass spectrometry (CG-MS) characterization showed that citral (29.62%) and niral (27.32%) are the main components for C. flexuosus, while d-carvone (62.09%) and d-limonene (29.58%) are the most dominant substances in C. carvi. By contrast, β-asarone (69.11%) was identified as the principal component of A. calamus (30.2%). The individual EO exhibits variable scavenging activities against ABTS and DPPH radicals. These effects were enhanced through the mixture of the three EOs. The optimal antioxidant formulation consisted of 20% C. flexuosus, 53% C. carvi, and 27% A. calamus for DPPHIC50. Whereas 17% C. flexuosus, 43% C. carvi, and 40% A. calamus is the best combination leading to the highest scavenging activity against ABTS radical. These findings suggest a new research avenue for EOs combinations to be developed as novel natural formulations useful in food and biopharmaceutical products.

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A novel desirability function for multi-response optimization and its application in chemical engineering

Cited by 10 publications

References 27 publications

Some applications of a novel desirability function in simultaneous optimization of multiple responses

Some applications of a novel desirability function in simultaneous optimization of multiple responses

Simultaneous Optimization of Extraction Yield, Phenolic Compounds and Antioxidant Activity of Moroccan Propolis Extracts: Improvement of Ultrasound-Assisted Technique Using Response Surface Methodology

Design of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity

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