A novel design of hollow microneedle for blood sample collection

Le-Thanh, Hoa; Tran‐Minh, Nhut; Karlsen, Frank

doi:10.1109/nems.2014.6908843

Cited by 6 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these forces, piercing force, buckling force, and bending force have the most impact to determine the overall geometry of the needles [ 29 ]. One of the analogies of the microneedle to the natural needle is a female mosquito’s fascicle with a slender, long, and hollow tube that does not break during skin penetration [ 27 ]. Various shapes of microneedles have been reported by considering these forces, with some representative designs summarized in Table 1 .…”

Section: Designmentioning

confidence: 99%

“…Several mechanical safety tests are usually required to evaluate microneedle reliability, such as bending moment, buckling force, insertion force, etc. [ 2 , 3 , 16 , 19 , 25 , 26 , 27 , 28 ]. Finite element analysis by software such as ANSYS, COMSOL, ABAQUS etc., was also applied [ 1 , 2 , 3 , 11 , 15 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

“…The flow rate is directly proportional to the inner diameter and inversely proportional to the length of the microneedle [ 31 ]. The fluid flow analysis or computational fluid dynamic (CFD) analysis has been performed [ 1 , 2 , 9 , 26 , 27 , 29 , 30 , 31 , 32 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In-Plane Si Microneedles: Fabrication, Characterization, Modeling and Applications

Mamun

Zhao

2022

Micromachines

View full text Add to dashboard Cite

Microneedles are getting more and more attention in research and commercialization since their advancement in the 1990s due to the advantages over traditional hypodermic needles such as minimum invasiveness, low material and fabrication cost, and precise needle geometry control, etc. The design and fabrication of microneedles depend on various factors such as the type of materials used, fabrication planes and techniques, needle structures, etc. In the past years, in-plane and out-of-plane microneedle technologies made by silicon (Si), polymer, metal, and other materials have been developed for numerous biomedical applications including drug delivery, sample collections, medical diagnostics, and bio-sensing. Among these microneedle technologies, in-plane Si microneedles excel by the inherent properties of Si such as mechanical strength, wear resistance, biocompatibility, and structural advantages of in-plane configuration such as a wide range of length, readiness of integration with other supporting components, and complementary metal-oxide-semiconductor (CMOS) compatible fabrication. This article aims to provide a review of in-plane Si microneedles with a focus on fabrication techniques, theoretical and numerical analysis, experimental characterization of structural and fluidic behaviors, major applications, potential challenges, and future prospects.

show abstract

Section: Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In-Plane Si Microneedles: Fabrication, Characterization, Modeling and Applications

Mamun

Zhao

2022

Micromachines

View full text Add to dashboard Cite

show abstract

“…Besides improving the MN design and the manner of application, the hyaluronidase, an enzyme that degrades hyaluronic acid in the extracellular matrix of the skin, can be co-injected with the drug formulations to reduce the fluid flow resistance [30,90]. Recently, Le-Thanh et al [91] proposed a novel hollow blood collection MN design, in which the diameter of the conduit near the tip is larger than the diameter of the conduit in the body part.…”

Section: Drug Delivery Efficiency and Pain Of Mnsmentioning

confidence: 99%

Microneedle, bio-microneedle and bio-inspired microneedle: A review

2017

Journal of Controlled Release

321

198

View full text Add to dashboard Cite

Microneedles (MNs) are micro-scale needles used for drug delivery and other targets. Micro-scale size endows them with many advantages over hypodermic needles, including painlessness, minimal invasiveness and convenient operation, but it may also lead to risk of mechanical failures, which should be prevented in the clinical applications of MNs. The objective of this review is mainly to introduce studies on the mechanics problems with respect to MNs. Firstly, the basic knowledge of MNs is introduced in brief, so that readers can understand the basic characteristics of MNs. Secondly, researches on inserting behavior and mechanical performances of MNs are discussed. Thirdly, literatures on the drug delivery and the pain resulted from the insertion of MNs are overviewed. Finally, some bio-microneedles and bio-inspired MNs are introduced.

show abstract

“…This formula has been used in a number of studies to compute P cr of various cross‐section structures, such as tapered hollow microneedles [8] and square pyramid columns [11]. In our previous work [20], this approach was applied particularly for PMNs. In the work reported in this Letter, (1) was utilised to estimate P cr of two different designs of microneedles such as PMNs and TMNs:

P_{normalcr} = \frac{E π^{2}}{2 L^{3}} \int_{0}^{L} \sum_{i = 0}^{n} I (z) . \cos^{2} (\frac{π z}{2 L}) d z

The second failure mechanism is because of the transverse force, that is, bending force.…”

Section: Geometry Optimisation By Structural Analysismentioning

confidence: 99%

Optimal design of polymer‐based microneedle for improved collection of whole blood from human fingers

Thanh

Le‐The

Nguyen

et al. 2014

Micro & Nano Letters

Self Cite

View full text Add to dashboard Cite

A highly applicable theoretical model and a simple, inexpensive mould-based method is introduced to design and fabricate the pyramid-shaped SU-8 microneedle. The main purpose is to be able to extract blood at point-of-care sites from up to 80% of typical nurse-home patients with a disorder of blood circulation in fingers and toes (Raynaud's phenomenon). Geometry optimisation was conducted based on the study of fracture force, which can be accurately predicted by the proposed theoretical model. The accuracy of the proposed theoretical model was confirmed by the finite element study and practical measurement. For practical verification, measurement of fracture force was conducted on fabricated SU-8 microneedles, including a 1470 µm-tall pyramid-shaped microneedle and a 1515 µm-tall traditional-shaped microneedle. The measurement results confirmed the improved strength of the proposed pyramid-shaped microneedle, especially of the pyramidal tips, which can exhibit significantly higher applied force with 2.82 N compared with the 0.51 N bevel tip. Practical tests of skin penetrability on human fingers showed that the microneedles fabricated with the proposed geometry may be sharp and strong enough to safely puncture human skin and long enough to reach the blood vessels.

show abstract

A novel design of hollow microneedle for blood sample collection

Cited by 6 publications

References 7 publications

In-Plane Si Microneedles: Fabrication, Characterization, Modeling and Applications

In-Plane Si Microneedles: Fabrication, Characterization, Modeling and Applications

Microneedle, bio-microneedle and bio-inspired microneedle: A review

Optimal design of polymer‐based microneedle for improved collection of whole blood from human fingers

Contact Info

Product

Resources

About