A novel DDS strategy, “dual-targeting”, and its application for antineovascular therapy

Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery

“…These results support the assumption that a specific ligand would have the capability to internalize the PEG-LP on the target cell surface but cannot exert significant effects on the cellular uptake of PEG-LPs and, in this regard, steric hindrance by PEG might be responsible for the suppression of cellular uptake. To ensure better cell selectivity or therapeutic efficacy, a dual-targeting system mediated by two types of specific ligands was used in previous studies [39][40]. The dual-targeting system had the ability to confer more efficient pharmacological effects than that of a single ligand version.…”

Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy

“…In addition, we employed a liposome with a diameter of 300 nm in the design of a dual-ligand formulation, not a 100 nm-diameter liposome, which is generally used for drug targeting to tumors [7][8][9]. We hypothesized that a large size would be more advantageous for targeting tumor endothelial cells than a small size by preventing the liposomes from extravasation to the tumor through permeable tumor blood vessels and would allow the liposomes to efficiently recognize the blood vessels.…”

“…It has been reported that ligand based liposomes that contain RGD or NGR motif peptides that are capable of targeting the neovasculatures can be used to deliver chemotherapeutic drugs [6][7][8][9]. The targeted liposomes showed efficient chemotherapeutic activity, particularly when the targeting was via internalizing ligands that facilitate the delivery of the therapeutic contents to an intracellular site of action via the endosome/lysosome pathway.…”

Molecular targeting of liposomal nanoparticles to tumor microenvironment

“…55 Decades of investigations on the molecular basis of angiogenesis have led to the discovery of several proteins expressed on solid tumor-associated angiogenic vessels, submit your manuscript | www.dovepress.com while they are barely detectable in established blood vessels. Examples of such proteins include α v integrins, the receptor for angiogenic growth factor, and other types of membranespanning molecules, such as transmembrane glycoprotein and aminopeptidase N.…”