A novel dairy-derived isolate that inhibits adipogenesis and significantly reduces weight gain in a high fat animal model

Rajic, Antonio; Dhulia, Janu; Hosking, Christopher G.; Autelitano, Dominic J.

doi:10.1016/j.idairyj.2010.02.002

Cited by 9 publications

(6 citation statements)

References 46 publications

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“…We already reported that oral administered bovine milk-derived α-lactalbumin had anti-inflammatory activity inhibiting by COX-2. 16) Recently, it has been reported that dairy protein affect expression of PPARγ mRNA 24,25) From these results, α-lactalbumin suppressed adipose tissue inflammation and the ameliorating effects of α-lactalbumin on glucose intolerance in GK rats might be mostly caused by enhancement of adiponectin. In addition, α-lactalbumin might improve insulin sensitivity via enhancement of adiponection in peripheral tissues, but we have no data about glucose uptake in peripheral tissued or hepatic glycogenesis induced by insulin.…”

Section: Discussionmentioning

confidence: 99%

Chronic Administration of Bovine Milk-Derived α-Lactalbumin Improves Glucose Tolerance <i>via</i> Enhancement of Adiponectin in Goto–Kakizaki Rats with Type 2 Diabetes

Yamaguchi

Takai

2014

Biological & Pharmaceutical Bulletin

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Inflammation has been implicated in development of the insulin resistance that leads to elevated blood sugar levels associated with type 2 diabetes. It is reported that salsalate, a common non-steroidal antiinflammatory drug, has been shown to decrease blood glucose concentration in some clinical study. Recently, we found that bovine milk-derived α-lactalbumin had anti-inflammatory activity caused by inhibiting cyclooxygenase-2. In this study, we investigated the effects of chronic administration of α-lactalbumin on glucose tolerance in Goto-Kakizaki (GK) rats, a model of type 2 diabetes. After 10 weeks administration of the α-lactalbumin (300 mg/kg, twice a day), oral glucose tolerance tests revealed significant decrements of blood glucose levels after glucose loading. However, significant differences of insulin levels were not observed among three GK rats groups after glucose loading. α-Lactalbumin treatment enhanced high molecular weight form of adiponectin and suppressed prostaglandin E2 levels in plasma. These results suggest that α-lactalbumin effectively decreased blood glucose levels after glucose loading in GK rat, and the decrements may be due to enhancement of adiponectin.Key words α-lactalbumin; diabetes; adiponectin; cyclooxygenase; prostaglandin Type 2 diabetes mellitus (formerly noninsulin-dependent diabetes mellitus (NIDDM)) is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. A number of lifestyle factors are known to be important to the development of type 2 diabetes, including: obesity (defined by a body mass index of greater than thirty), lack of physical activity, poor diet, stress, and urbanization. 1) Dietary factors also influence the risk of developing type 2 diabetes. Consumption of sugarsweetened drinks in excess is associated with an increased risk.2)

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Section: Discussionmentioning

confidence: 99%

Chronic Administration of Bovine Milk-Derived α-Lactalbumin Improves Glucose Tolerance <i>via</i> Enhancement of Adiponectin in Goto–Kakizaki Rats with Type 2 Diabetes

Yamaguchi

Takai

2014

Biological & Pharmaceutical Bulletin

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“…Although whey protein and its derivatives confer health benefits against several metabolic diseases (Patel, 2015), it has not been well established that whey protein prevents adipogenesis. Enriched whey protein fractions inhibit adipogenesis of 3T3-L1 (Rajic et al, 2010). More recently, D'Souza et al (D'Souza et al, 2020) demonstrated that whey protein hydrolyzed by pepsin and pancreatin enhances 3T3-L1 adipocyte differentiation and triacylglycerol accumulation.…”

Section: Ki 31-w and Ki 36-w Significantly Reduce Lipid Accumulation mentioning

confidence: 99%

Bioconversion Products of Whey by Lactic Acid Bacteria Exert Anti-Adipogenic Effect

Lee¹,

Hyun²,

Yoon³

et al. 2021

Food Sci Anim Resour

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“…As proteínas nos alimentos possuem funções além daquelas de nutrição. A maioria das atividades fisiológicas das proteínas são realizadas por sequências de peptídeos, oriundos de uma proteína original, que se tornam ativos quando são clivados (RIZZELLO et al, 2016). Peptídeos bioativos (PBA) são pequenas sequências de aminoácidos, geralmente de 2 a 30aa, e com massa molecular inferior a 15kDa.…”

Section: Peptídeos Bioativosunclassified

“…A Organização Mundial da Saúde (OMS), relata que 36 milhões de mortes, a cada ano, acontecem devido a ocorrência e complicações de DCNT. Embora menos potentes em seus efeitos quando comparados as drogas sintéticas, há evidências científicas da atividade de PBA com atividades anti-hipertensivas, antidiabéticas, antiobesidade e neutralizantes de radicais livres no organismo ( LI-CHAN; JIANG, https://proceedings.science/p/159577?lang=pt-br DOI: 10.17648/siics-2022-159577 2010; ; LI-CHAN, 2015;RIZZELLO et al, 2016;DE LIMA et al, 2017;MECHMECHE et al, 2017;MINE).…”

Section: Peptídeos Bioativosunclassified

Peptídeos Bioativos E Atividade Antiobesidade

Bellaver¹,

Kempka²

2023

Anais Do II Simpósio Internacional Interdisciplinar Dos Cursos Da Área Da Saúde

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É cada vez mais evidente o interesse de pesquisadores acerca do que é e como promover uma alimentação saudável. A dieta desempenha importante papel na prevenção e/ou retardamento da progressão de doenças crônicas como câncer, diabetes e doenças cardiovasculares, aumentando a conscientização da população acerca da dieta no seu bem-estar, sendo a crença no benefício dos alimentos à base para o aumento no interesse por alimentos nutracêuticos e funcionais (HSIEH; OFORI, 2010).O termo nutracêutico é uma combinação das palavras "nutrição" e "farmacêutico", sendo geralmente definido como um alimento ou de um alimento que fornece benefícios para a saúde, quando do seu consumo, incluindo a prevenção e/ou tratamento de patologias (PRABU et al., 2012). Embora não haja uma distinção clara entre alimentos funcionais e nutracêuticos, define-se alimentos funcionais como aqueles que se assemelham ou podem até ser alimentos convencionais que, quando consumidos como parte de uma dieta, demonstram ter benefícios fisiológicos na redução de doenças cônicas, por exemplo, além de desempenharem as funções básicas de nutrição (KAUR; DAS, 2011).Condições fisiológica podem alterar a rota de alimentos que, potencialmente, apresentam características funcionais, uma vez da diversa gama de reações que podem acontecer no organismo frente uma condição não controlada. A fim de se tentar garantir que as qualidades do alimento possam desempenham as devidas funções,

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A novel dairy-derived isolate that inhibits adipogenesis and significantly reduces weight gain in a high fat animal model

Cited by 9 publications

References 46 publications

Chronic Administration of Bovine Milk-Derived α-Lactalbumin Improves Glucose Tolerance <i>via</i> Enhancement of Adiponectin in Goto–Kakizaki Rats with Type 2 Diabetes

Chronic Administration of Bovine Milk-Derived α-Lactalbumin Improves Glucose Tolerance <i>via</i> Enhancement of Adiponectin in Goto–Kakizaki Rats with Type 2 Diabetes

Bioconversion Products of Whey by Lactic Acid Bacteria Exert Anti-Adipogenic Effect

Peptídeos Bioativos E Atividade Antiobesidade

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