A Novel Cryogenic Approach to 3D Printing Cytocompatible, Conductive, Hydrogel-Based Inks

Naseri, Aida Shoushtari Zadeh; Fay, Cormac; Nattestad, Andrew; Ryder, Gregory; Sayyar, Sepidar; Yue, Zhilian; Liu, Xiao; Officer, David L.; Wallace, Gordon G.

doi:10.1089/3dp.2022.0169

Cited by 2 publications

(5 citation statements)

References 59 publications

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“…Additionally, the introduction of a cryogenic 3D printing method for conductive hydrogel inks has produced cytocompatible, conductive scaffolds suitable for tissue engineering applications [91].…”

Section: Stretchable and Conductive Hydrogelsmentioning

confidence: 99%

“…The creation of stretchable and conductive hydrogels, which maintain mechanical flexibility and electrical conductivity under stress, presents its own set of challenges [89,90,92]. Further optimization is necessary for their integration with biological tissues for applications in bioelectronics and tissue engineering [91,93]. Issues of scalability, reproducibility, self-healing efficiency, degradation rates, and environmental impact remain significant hurdles [21,94,[98][99][100].…”

Section: Limitations Of Using 3d Printed Hydrogelsmentioning

confidence: 99%

“…Innovations are merging hydrogels with materials like liquid metals [94,100] and conducting polymers [93,95], aiming to surpass current limitations and augment functionality. The development of next-generation implantable devices is being driven by advanced manufacturing techniques [21,89,91] and biohybrid interfaces [93]. Additionally, the exploration of smart sensing systems for health monitoring and environmental sensing [96,97] emphasizes the quest for sustainable and biodegradable solutions [99].…”

Section: Stretchable and Conductive Hydrogelsmentioning

confidence: 99%

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Three-Dimensional Printing Strategies for Enhanced Hydrogel Applications

Omidian,

Mfoafo

2024

Gels

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This study explores the dynamic field of 3D-printed hydrogels, emphasizing advancements and challenges in customization, fabrication, and functionalization for applications in biomedical engineering, soft robotics, and tissue engineering. It delves into the significance of tailored biomedical scaffolds for tissue regeneration, the enhancement in bioinks for realistic tissue replication, and the development of bioinspired actuators. Additionally, this paper addresses fabrication issues in soft robotics, aiming to mimic biological structures through high-resolution, multimaterial printing. In tissue engineering, it highlights efforts to create environments conducive to cell migration and functional tissue development. This research also extends to drug delivery systems, focusing on controlled release and biocompatibility, and examines the integration of hydrogels with electronic components for bioelectronic applications. The interdisciplinary nature of these efforts highlights a commitment to overcoming material limitations and optimizing fabrication techniques to realize the full potential of 3D-printed hydrogels in improving health and well-being.

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Section: Stretchable and Conductive Hydrogelsmentioning

confidence: 99%

Section: Limitations Of Using 3d Printed Hydrogelsmentioning

confidence: 99%

Section: Stretchable and Conductive Hydrogelsmentioning

confidence: 99%

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Three-Dimensional Printing Strategies for Enhanced Hydrogel Applications

Omidian,

Mfoafo

2024

Gels

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“…The design of the printer, generated using open-source 3D CAD software (FreeCAD, 1.8.4), is shown in Figure 2. The 3D Cartesian movement was achieved through the foundation of an open-source 3D printer (ME2, Me3D Pty Ltd., North Wollongong, NSW, Australia), with modifications made to remove the heated extrusion system and enhance the z-axis [44,46]. The print base was developed with a holder specifically designed to fit a standard petri dish, serving as a clean print base solution.…”

Section: Fabrication System Design 221 3d Printer Designmentioning

confidence: 99%

“…As interest in 3D printing expanded, there was a corresponding demand for additional materials. Typically, this was left to industrial entities, but there are a few exceptions where low-cost 3D printers were proposed for metals [41,42], ceramics [43], and bio-related materials [44][45][46].…”

Section: Introductionmentioning

confidence: 99%

Cost-Effective 3D Printing of Silicone Structures Using an Advanced Intra-Layer Curing Approach

Fay,

2023

Technologies

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We present an advanced, low-cost 3D printing system capable of fabricating intricate silicone structures using commercially available off-the-shelf materials. Our system used a custom-designed, motorised syringe pump with a driving lead screw and excellent control of material extrusion to accommodate the high viscosity of silicone printing ink, which is composed of polydimethylsiloxane (PDMS), diluent, and a photo-initiator (LAP). We modified an open-source desktop 3D printer to mount the syringe pump and programmed it to deposit controlled intricate patterns in a layer-by-layer fashion. To ensure the structural integrity of the printed objects, we introduced an intra-layer curing approach that fused the deposited layers using a custom-built UV curing system. Our experiments demonstrated the successful fabrication of silicone structures at different infill percentages, with excellent resolution and mechanical properties. Our low-cost solution (costing less than USD 1000 and requiring no specialised facilities or equipment) shows great promise for practical applications in areas such as micro-fluidics, prosthesis, and biomedical engineering based on our initial findings of 300 μm width channels (with excellent scope for smaller channels where desirable) and tunable structural properties. Our work represents a significant advance in low-cost desktop 3D printing capabilities, and we anticipate that it could have a broad impact on the field by providing these capabilities to scholars without the means to purchase expensive fabrication systems.

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A Novel Cryogenic Approach to 3D Printing Cytocompatible, Conductive, Hydrogel-Based Inks

Cited by 2 publications

References 59 publications

Three-Dimensional Printing Strategies for Enhanced Hydrogel Applications

Three-Dimensional Printing Strategies for Enhanced Hydrogel Applications

Cost-Effective 3D Printing of Silicone Structures Using an Advanced Intra-Layer Curing Approach

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