A novel CRISPR/Cas12a biosensor for sensitive detection of Helicobacter pylori from clinical patients

Yu, Luxin; Lan, Huatao; Zhang, Yanting; Yi, Hai; Shu, Weitong; Cui, Kai; He, Wanjun; Chen, Mei; Huang, Qianying; Li, Li; Huang, Kaisong; Chen, Zhangquan; Jiang, Dan; Xu, Guangxian

doi:10.1016/j.snb.2024.135818

Sensors and Actuators B: Chemical

2024

DOI: 10.1016/j.snb.2024.135818

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A novel CRISPR/Cas12a biosensor for sensitive detection of Helicobacter pylori from clinical patients

Luxin Yu,

Huatao Lan,

Yanting Zhang

et al.

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CRISPR-Based Biosensors for Medical Diagnosis: Readout from Detector-Dependence Detection Toward Naked Eye Detection

Hu,

Yin,

Bai

et al. 2024

Biosensors

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The detection of biomarkers (such as DNA, RNA, and protein) plays a vital role in medical diagnosis. The CRISPR-based biosensors utilize the CRISPR/Cas system for biometric recognition of targets and use biosensor strategy to read out biological signals without the employment of professional operations. Consequently, the CRISPR-based biosensors demonstrate great potential for the detection of biomarkers with high sensitivity and specificity. However, the signal readout still relies on specialized detectors, limiting its application in on-site detection for medical diagnosis. In this review, we summarize the principles and advances of the CRISPR-based biosensors with a focus on medical diagnosis. Then, we review the advantages and progress of CRISPR-based naked eye biosensors, which can realize diagnosis without additional detectors for signal readout. Finally, we discuss the challenges and further prospects for the development of CRISPR-based biosensors.

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CRISPR-Based Biosensors for Medical Diagnosis: Readout from Detector-Dependence Detection Toward Naked Eye Detection

Hu,

Yin,

Bai

et al. 2024

Biosensors

View full text Add to dashboard Cite

show abstract

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A novel CRISPR/Cas12a biosensor for sensitive detection of Helicobacter pylori from clinical patients

Cited by 1 publication

References 33 publications

CRISPR-Based Biosensors for Medical Diagnosis: Readout from Detector-Dependence Detection Toward Naked Eye Detection

CRISPR-Based Biosensors for Medical Diagnosis: Readout from Detector-Dependence Detection Toward Naked Eye Detection

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