A novel coplanar probe design for fast scanning of edema in human brain tissue via dielectric measurements

Reinecke, Tobias; Hagemeier, Lars; Ahrens, Stephen F.; Doroschenko, Y.; Klintschar, Michael; Zimmermann, Stefan

doi:10.1016/j.snb.2015.06.002

Cited by 11 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Figure 9a-c shows the coplanar device used for brain tissue, the basic schematic of the device, and the base of the actual probe, respectively. [82] The effective permittivity is determined by measuring the phase shift of the transmitted electromagnetic wave, which then enables the determination of the water content and thus the extent of edema. Figure 9d shows the plot of permittivity against brain water content.…”

Section: Coplanar Probe (Copp)mentioning

confidence: 99%

See 1 more Smart Citation

Recent Technological Developments in the Diagnosis and Treatment of Cerebral Edema

Deshmukh

Dabbagh

Jiang

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Latest technological advancements in neurocritical care have translated to improved clinical outcomes and have paved the way for the effective diagnosis and treatment of cerebral edema. Effective management of cerebral edema has the potential to provide a personalized treatment by obtaining the complete pathophysiological information of the patient. The aims of this review are to inform the reader about the research and development in this field in the past decade as well as the materialization of scientific literature through patents. There is a growing interest in multimodal monitoring of the diseased brain as it provides a necessary means to implement effective intervention strategies. Although there is a gradual shift toward the adoption of noninvasive devices for research purposes, their clinical applications are hindered by their inaccuracies. However, the inherent risk of complication and high costs of implementation challenge the status quo. The role of neuroprotectants is explored and the combination of neurodiagnostic and neuroprotective approaches is proposed. Finally, the impacts of the current state of global affairs are discussed and it is predicted that the rising number of traumatic brain injury patents will inevitably translate to improvements in technologies to effectively address cerebral edema.

show abstract

Section: Coplanar Probe (Copp)mentioning

confidence: 99%

“…However, the author acknowledges that the sensor could be implemented in vivo upon sterilization. [82]…”

Section: Coplanar Probe (Copp)mentioning

confidence: 99%

Recent Technological Developments in the Diagnosis and Treatment of Cerebral Edema

Deshmukh

Dabbagh

Jiang

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

show abstract

“…2(a). It was originally designed for complex permittivity measurements of tissue in the MHz regime in order to determine the water content [22]. Based on the successful employment of this sensing principle, it was subsequently transferred to cell growth monitoring at low frequencies.…”

Section: Introductionmentioning

confidence: 99%

Continuous noninvasive monitoring of cell growth in disposable bioreactors

Reinecke

Biechele

Sobociński

et al. 2017

Sensors and Actuators B: Chemical

Self Cite

View full text Add to dashboard Cite

To ensure high quality output of biotechnological processes, relevant process parameters need to be monitored. As bioprocesses are increasingly executed in single use bioreactors, there is an increasing demand for new sensors applicable to these processes. In this work, we investigate different approaches for continuous non-invasive cell growth monitoring, especially for single use bioreactor applications. Therefore, the permittivity of the cell culture is used as a measure for the biomass. In a first step, a measuring procedure based on the transmission measurement of an electromagnetic wave is investigated. It appears that the penetration depth of this sensor is not sufficient for a noninvasive measurement through the polymer wall of a single use bioreactor. Therefore, alternative setups based on magnetic induction are investigated. The initial setup is very simple. It consists of a planar coil connected to an impedance analyzer. The coil is attached to the outside of the polymer foil of the single use bioreactor and an impedance spectrum is measured. To evaluate the sensor, E. coli cultivations are performed in a modified cultivation setup, which enables measurements through the polymer foil of a Sartorius BIOSTAT® CultiBag RM, and additionally allows sampling of culture medium for optical density reference measurements. The resonance peak of the coil in the impedance spectrum, is observed as measure for the optical density. Regardless of the simple sensor construction, we found a good correlation between optical density and the damping ratio of the resonance peak. However, the sensor signal shows saturation towards high optical densities. Therefore, an LTCC coil producing a higher magnetic flux density in the culture medium is investigated subsequently. This sensor shows a linear response up to high optical densities, but the sensitivity is reduced compared to the former used coil and therefore scattering of the data is increased. However, to increase the sensitivity, a linear variable differential transformer is realized. Using this setup, the influence of the primary magnetic flux is eliminated from the measuring voltage. This approach delivers the most promising results, as the sensor response is linear up to high optical densities and data scattering is low. Fig. 1. Four-electrode measurement without (left) and with (right) polymer foil (CST Simulation at 1 kHz with discrete port excitation (1 V Amplitude), 190000 Hexahedral Mesh cells and open (add space) boundaries).

show abstract

“…Weiterhin können sie als Tastkopf ausgeführt werden, wodurch eine Probenpräparation entfällt und schnelle zerstörungsfreie Messungen ermöglicht werden. In [8]…”

Section: Introductionunclassified

“…Da Γ und z jeweils abhängig von der effektiven Permittivität sind, kann diese nach[10] nummerisch aus (1) bestimmt werden. Weitere Ausführungen zu den Besonderheiten bei der Bestimmung der effektiven Permittivität bei Verwendung des beschriebenen Tastkopfs finden sich in[8]. Im Allgemeinen ist der Realteil einer Permittivität ein Maß für die Polarisierbarkeit des Materials und der Imaginärteil ein Maß für die dielektrischen Verluste.…”

unclassified

P9.2 - Einfache Kalibrierung von koplanaren Tastköpfen zur Messung der komplexen Permittivität

Reinecke¹,

Ahrens²,

Zimmermann³

2015

Tagungsband

Self Cite

View full text Add to dashboard Cite

A novel coplanar probe design for fast scanning of edema in human brain tissue via dielectric measurements

Cited by 11 publications

References 19 publications

Recent Technological Developments in the Diagnosis and Treatment of Cerebral Edema

Recent Technological Developments in the Diagnosis and Treatment of Cerebral Edema

Continuous noninvasive monitoring of cell growth in disposable bioreactors

P9.2 - Einfache Kalibrierung von koplanaren Tastköpfen zur Messung der komplexen Permittivität

Contact Info

Product

Resources

About