A Novel Contributor to Endometrial Receptivity: Endometrial Microbiota

Abstract

CitationTohma YA, Esin S. A novel contributor to endometrial receptivity: Endometrial microbiota. Gynecol Obstet Res Open

Biologia Futura: endometrial microbiome affects endometrial receptivity from the perspective of the endometrial immune microenvironment

“…Nonetheless, the mechanism by which the human endometrial microbiome affects embryo implantation remains unclear (Hashimoto and Kyono 2019;Franasiak et al 2016). The synchronization of the development of high-quality embryos and an acceptable endometrium is crucial for the success of embryo implantation (Tohma and Esin 2017). About one-third of implantation failures are caused by embryo quality, whereas the rest are due to poor endometrial receptivity (Idelevich and Vilella 2020).…”

“…The human endometrium is maintained by the equilibrium of several components, including the microbiome, cellular immune response, and cytokines that affect endometrial receptivity (Hashimoto and Kyono 2019;Al-Nasiry et al 2020;Benner et al 2018;Molina et al 2020;Kayama et al 2020;Zhou et al 2018;Khalesi et al 2019;Trush et al 2020;Fu et al 2020;Łaniewski et al 2017;Pekmezovic et al 2019). The balance of inflammatory factors is important for the regulation of blastocyst adhesion in the epithelial endometrial wall (Bardos et al 2019;Tohma and Esin 2017). A non-Lactobacillus-dominated endometrium status may break the balance and trigger an inflammatory response in the endometrium, which would affect endometrial receptivity (Hashimoto and Kyono 2019;Moreno and Simon 2018;Haahr et al 2020).…”