A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties

Lu, Qi; Wei, Daixu; Cheng, Jiejun; Xu, Jianrong; Zhu, Jun

doi:10.1016/j.jssc.2012.03.016

Cited by 8 publications

(5 citation statements)

References 42 publications

(47 reference statements)

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“…Lanthanide‐doped upconversion NPs (UCNPs) have been used as important biomaterials for fluorescence and MRI imaging . UCNPs transfer the energy of NPs from a lower energy to a higher energy through a multiphoton process.…”

Section: Introductionmentioning

confidence: 99%

“…Lanthanide-doped upconversion NPs (UCNPs)h ave been used as important biomaterialsf or fluorescencea nd MRI imaging. [5,6] UCNPs transfer the energy of NPs from al ower energy to ah igher energy through am ultiphoton process. Therefore, UCNPse xhibit several advantages for in vitro bioimaging because of their unique optical properties such as al ongl uminescencel ifetime, large anti-Stokes shift, low photobleaching, and high photostability.…”

Section: Introductionmentioning

confidence: 99%

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Rare‐Earth‐Based Nanoparticles with Simultaneously Enhanced Near‐Infrared (NIR)‐Visible (Vis) and NIR‐NIR Dual‐Conversion Luminescence for Multimodal Imaging

et al. 2016

Chemistry An Asian Journal

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Multifunctional NaGdF4 :Yb(3+),Er(3+),Nd(3+) @NaGdF4 :Nd(3+) core-shell nanoparticles (called Gd:Yb(3+),Er(3+),Nd(3+) @Gd:Nd(3+) NPs) with simultaneously enhanced near-infrared (NIR)-visible (Vis) and NIR-NIR dual-conversion (up and down) luminescence (UCL/DCL) properties were successfully synthesized. The resulting core-shell NPs simultaneously emitted enhanced UCL at 522, 540, and 660 nm and DCL at 980 and 1060 nm under the excitation of a 793 nm laser. The enhanced UCL and DCL can be explained by complex energy-transfer processes, Nd(3+) →Yb(3+) →Er(3+) and Nd(3+) →Yb(3+) , respectively. The effects of Nd(3+) concentration and shell thickness on the UCL/DCL properties were systematically investigated. The UCL and DCL properties of NPs were observed under the optimal conditions: a shell Nd(3+) content of 20 % and a shell thickness of approximately 5 nm. Moreover, the Gd:Yb(3+) ,Er(3+) ,Nd(3+) @Gd:20 % Nd(3+) NPs exhibited remarkable magnetic resonance imaging (MRI) properties similar to that of a clinical agent, Omniscan. Thus, the core-shell NPs with excellent UCL/DCL/magnetic resonance imaging (MRI) properties have great potential for both in vitro and in vivo multimodal bioimaging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rare‐Earth‐Based Nanoparticles with Simultaneously Enhanced Near‐Infrared (NIR)‐Visible (Vis) and NIR‐NIR Dual‐Conversion Luminescence for Multimodal Imaging

et al. 2016

Chemistry An Asian Journal

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“…[6,7] Therefore, several biocompatible nanomaterials have been designed to obtain multifunctional contrast agents. [8][9][10] As a kind of versatile materials, ZnO was cheap and biocompatible. [11] Various photoluminescent ZnO nanoparticles have been investigated and demonstrated their promising biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Lymph-Targeted ZnO:Gd@Hyaluronic Acid Nanospheres: Preparation and Application in Tumor Diagnose

Cheng¹,

Zhang²,

Zhu³

et al. 2016

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A novel multi-modal lymph-targeted contrast agent, ZnO:Gd@hyaluronic acid (HA) nanospheres, is prepared by Gd dopped ZnO quantum dot, modified by silica shell and grafted by HA molecule. The physicochemical properties are characterized and the lymphatic targeting is evaluated in vitro. Moreover, the contrast agent is used for in vivo lymphoma magnetic resonance imaging (MRI). The results show that the ZnO:Gd@HA nanospheres with 19% of quantum yield and 5.8 mM-1 •s-1 of relaxivity could be used for in vivo lymphatic targeting studies. Furthermore, they are highly targeted to lymph system in vitro and in vivo, and highlight their MRI in lymph tumor. Thus, the novel MRI contrast agent can be taken up selectively by lymphatic system and used as a potential multi-modal contrast agent in lymphatic system.

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“…7 Moreover, our group has made an effort to prepare multifunctional nanoprobes with MR and luminescent imaging based on quantum dot or upconverting nanoparticle, which is highly desirable due to their ability to be detected at two different modes, optical and T 1 -weighted magnetical imaging. 8,9 However, given recent advances in nanoprobes, the research on the design and synthesis of the multifunctional composites based on Gd-DTPA with high luminescent efficiency and biocompatibility still remains a great challenge.…”

Section: Introductionmentioning

confidence: 99%

One-step synthesis of surface passivated carbon microspheres for enhanced photoluminescence and their application in multifunctional magnetic-fluorescent imaging

et al. 2015

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A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties

Cited by 8 publications

References 42 publications

Rare‐Earth‐Based Nanoparticles with Simultaneously Enhanced Near‐Infrared (NIR)‐Visible (Vis) and NIR‐NIR Dual‐Conversion Luminescence for Multimodal Imaging

Rare‐Earth‐Based Nanoparticles with Simultaneously Enhanced Near‐Infrared (NIR)‐Visible (Vis) and NIR‐NIR Dual‐Conversion Luminescence for Multimodal Imaging

Multifunctional Lymph-Targeted ZnO:Gd@Hyaluronic Acid Nanospheres: Preparation and Application in Tumor Diagnose

One-step synthesis of surface passivated carbon microspheres for enhanced photoluminescence and their application in multifunctional magnetic-fluorescent imaging

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