Abstract:During the prodromal stage of Alzheimer’s disease (AD), neurodegenerative changes can be identified by measuring volumetric loss in AD-prone brain regions on MRI. Cognitive assessments sensitive enough to measure the early brain-behavior manifestations of AD and correlate with biomarkers of neurodegeneration are needed to identify and monitor individuals at risk for dementia. Weak sensitivity to early cognitive change has been one major limitation of traditionally used assessment tools. In this study, we focus… Show more
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