A novel colorimetric technique for estimating iron in magnetosomes of magnetotactic bacteria based on linear regression

Rajalakshmi, Arumugam; Anjukam, Elamaran; Ramesh, Manickam; Kuppuswamy, Kavitha; Puvanakrishnan, Rengarajulu; Ramesh, Balasubramanian

doi:10.1007/s00203-022-02901-1

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…In recent years, a particular interest is attracted to biogenic magnetic nanoparticles. Since “bacteria with motility directed by the local geomagnetic field have been observed in marine sediments” by Richard Blakemore in 1975 [ 12 ], a large number of studies have been carried out in order to determine the properties of such particles, or, so-called magnetosomes, which are the intracytoplasmic membrane vesicles, containing magnetic nanocrystal covered in a lipid bilayer with proteins [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. The most important applications of such biogenic nanoparticles include the biosensors for medical diagnostics, and cancer diagnostics, in particular, vehicles for target delivery of anticancer agents [ 21 ], hyperthermia treatment employing alternating electromagnetic field [ 22 ], and tumor diagnostics using magnetic resonance imaging (MRI) [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

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Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

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Section: Introductionmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

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Purification, Characterization, and Assessment of Anticancer Activity of Iron Oxide Nanoparticles Biosynthesized by Novel Thermophilic Bacillus tequilensis ASFS1‏

Satarzadeh,

Shakibaie,

Forootanfar

et al. 2024

Journal of Basic Microbiology

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Magnetic nanoparticles (MNPs), particularly iron oxide nanoparticles (IONPs), are a fascinating group of nanoparticles that have been considerably investigated for biomedical applications because of their superparamagnetic properties, biodegradable nature, and biocompatibility. A novel Gram‐positive moderately thermophilic bacterial strain, namely Bacillus tequilensis ASFS.1, was isolated and identified. This strain is capable of producing superparamagnetic Fe3O4 nanoparticles and exhibiting magnetotaxis behavior. This strain swimming behavior was investigated under static and dynamic environments, where it behaved very much similar to the magnetotaxis in magnetotactic bacteria. This study is the first report of a bacterium from the Bacillaceae family that has the potential to intracellular biosynthesis of IONPs. MNPs were separated by a magnetic and reproducible method which was designed for the first time for this study. In addition, UV‐visible spectrophotometer, Fourier‐transform infrared spectroscopy, vibrating sample magnetometer, field emission scanning electron microscopy (FESEM), X‐ray diffraction, and thermal gravimetric analysis were utilized to characterize the bio‐fabricated magnetite nanoparticles. Analysis of the particle size distribution pattern of the biogenic MNPs by FESEM imaging revealed the size range of 10–100 nm with the size range of 10–40 nm MNPs being the most frequent particles. VSM analysis demonstrated that biogenic MNPs displayed superparamagnetic properties with a high saturation magnetization value of 184 emu/g. After 24 h treatment of 3T3, U87, A549, MCF‐7, and HT‐29 cell lines with the biogenic MNPs, IC50 values were measured to be 339, 641, 582, 149, and 184 μg mL−1, respectively. This study presents the novel strain ASFS.1 capable of magnetotaxis by the aid of its magnetite nanoparticles and paving information on isolation, characterization, and in vitro cytotoxicity of its MNPs. The MNPs showed promising potential for biomedical applications, obviously subject to additional studies.

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Discovery of antibacterial biogenic magnetosome nanoparticles from Providencia sp. MTBPRB-1: Screening, purification and characterization

Rajalakshmi,

Ramesh,

Sai Thanga Abirami

et al. 2024

J Biosci

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A novel colorimetric technique for estimating iron in magnetosomes of magnetotactic bacteria based on linear regression

Cited by 3 publications

References 29 publications

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Purification, Characterization, and Assessment of Anticancer Activity of Iron Oxide Nanoparticles Biosynthesized by Novel Thermophilic Bacillus tequilensis ASFS1‏

Discovery of antibacterial biogenic magnetosome nanoparticles from Providencia sp. MTBPRB-1: Screening, purification and characterization

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