A novel closed-loop EEG-tDCS approach to promote responsiveness of patients in minimally conscious state: A study protocol

Martens, Géraldine; Ibanez-Soria, David; Barra, Alice; Soria-Frisch, Aureli; Piarulli, Andrea; Gosseries, Olivia; Salvador, Ricardo; Rojas, Alexis Sossa; Nitsche, Michael A.; Kroupi, Eleni; Laureys, Steven; Ruffini, Giulio; Thibaut, Aurore

doi:10.1016/j.bbr.2021.113311

Cited by 15 publications

(12 citation statements)

References 47 publications

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“…Targeting additional or other cortical networks that have been implicated in FOG, including the limbic [34][35][36] and/or cerebellar locomotor networks, 8,37 may thus be needed to exert an optimal effect on FOG. Future trials may also consider using tDCS optimization techniques to tailor interventions to individual brain anatomy 38,39 and consider possible effects of peripheral nerve stimulation. 40 The tDCS intervention was well tolerated and well attended within the intensive 2-week phase.…”

Section: Discussionmentioning

confidence: 99%

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Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial

et al. 2021

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A BS T RA C T : Background: Treatments of freezing of gait (FOG) in Parkinson's disease are suboptimal.Objective: The aim of this study was to evaluate the effects of multiple sessions of transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex and primary motor cortex (M1) on FOG. Methods: Seventy-seven individuals with Parkinson's disease and FOG were enrolled in a double-blinded randomized trial. tDCS and sham interventions comprised 10 sessions over 2 weeks followed by five once-weekly sessions. FOG-provoking test performance (primary outcome), functional outcomes, and self-reported FOG severity were assessed.Results: Primary analyses demonstrated no advantage for tDCS in the FOG-provoking test. In secondary analyses, tDCS, compared with sham, decreased self-reported FOG severity and increased daily living step counts. Among individuals with mild-to-moderate FOG severity, tDCS improved FOG-provoking test time and self-report of FOG. Conclusions: Multisession tDCS targeting the left dorsolateral prefrontal cortex and M1 did not improve laboratory-based FOG-provoking test performance. Improvements observed in participants with mild-tomoderate FOG severity warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

“…severity, functional outcomes, and subjective FOG severity MDS-UPDRS-III 38(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) …”

mentioning

confidence: 99%

Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial

et al. 2021

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“…Several studies (three studies about two targets 10,28,29 and two studies about multi-targets 15,19 ) have attempted to use multi-target therapy for pDoC.…”

Section: Multi-targetmentioning

confidence: 99%

An update on noninvasive neuromodulation in the treatment of patients with prolonged disorders of consciousness

Wan,

Zhang,

et al. 2024

CNS Neurosci Ther

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BackgroundWith the improvement of emergency techniques, the survival rate of patients with severe brain injury has increased. However, this has also led to an annual increase in the number of patients with prolonged disorders of consciousness (pDoC). Hence, recovery of consciousness is an important part of treatment. With advancing techniques, noninvasive neuromodulation seems a promising intervention. The objective of this review was to summarize the latest techniques and provide the basis for protocols of noninvasive neuromodulations in pDoC.MethodsThis review summarized the advances in noninvasive neuromodulation in the treatment of pDoC in the last 5 years.ResultsVariable techniques of neuromodulation are used in pDoC. Transcranial ultrasonic stimulation (TUS) and transcutaneous auricular vagus nerve stimulation (taVNS) are very new techniques, while transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are still the hotspots in pDoC. Median nerve electrical stimulation (MNS) has received little attention in the last 5 years.ConclusionsNoninvasive neuromodulation is a valuable and promising technique to treat pDoC. Further studies are needed to determine a unified stimulus protocol to achieve optimal effects as well as safety.

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“…Pairing neuroimaging techniques, such as EEG or fMRI, with brain stimulation can assist in timing stimulation to an optimal brain state. TMS or tDCS (Leite et al, 2017; Martens et al, 2021) paired with electroencephalography (EEG), which measures ongoing neural activity at a millisecond timescale, can also synchronize stimulation to an optimal brain state (Zrenner et al, 2018). In both TMS and tDCS a targeted network can be excited or inhibited by an ongoing task or intervention concurrent with the NIBS intervention (Esse Wilson, Quinn, et al, 2018; Esse Wilson, Trumbo, et al, 2018; Li et al, 2019; Parmar et al, 2021; Salehinejad et al, 2021; Sathappan et al, 2019).…”

Section: Future Directionsmentioning

confidence: 99%

The use of noninvasive brain stimulation techniques in autism spectrum disorder

Oberman,

Francis,

Lisanby

2023

Autism Research

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Noninvasive brain stimulation (NIBS) techniques, including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), have recently emerged as alternative, nonpharmacological interventions for a variety of psychiatric, neurological, and neurodevelopmental conditions. NIBS is beginning to be applied in both research and clinical settings for the treatment of core and associated symptoms of autism spectrum disorder (ASD) including social communication deficits, restricted and repetitive behaviors, irritability, hyperactivity, depression and impairments in executive functioning and sensorimotor integration. Though there is much promise for these targeted device‐based interventions, in other disorders (including adult major depressive disorder (MDD) and obsessive compulsive disorder (OCD) where rTMS is FDA cleared), data on the safety and efficacy of these interventions in individuals with ASD is limited especially in younger children when neurodevelopmental interventions typically begin. Most studies are open‐label, small scale, and/or focused on a restricted subgroup of individuals with ASD. There is a need for larger, randomized controlled trials that incorporate neuroimaging in order to develop predictive biomarkers of treatment response and optimize treatment parameters. We contend that until such studies are conducted, we do not have adequate estimates of the safety and efficacy of NIBS interventions in children across the spectrum. Thus, broad off‐label use of these techniques in this population is not supported by currently available evidence. Here we discuss the existing data on the use of NIBS to treat symptoms related to ASD and discuss future directions for the field.

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A novel closed-loop EEG-tDCS approach to promote responsiveness of patients in minimally conscious state: A study protocol

Cited by 15 publications

References 47 publications

Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial

Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial

An update on noninvasive neuromodulation in the treatment of patients with prolonged disorders of consciousness

The use of noninvasive brain stimulation techniques in autism spectrum disorder

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