“…The novel α-trifluoromethyl chalcones ( 2 – 7 ) and known 1 [ 12 ] , were synthesized from the related chalcones [ 13 , 14 , 15 , 16 ] including novel 10 and 11 , which were obtained by Claisen-Schmidt condensation of aryl methyl ketones and aromatic aldehydes. In target compounds 1 – 7 , the aromatic aldehyde was either unsubstituted or substituted with one of three electron withdrawing groups (F, CF 3 , or NO 2 ) or an electron donating group (NMe 2 ) for comparative purposes.…”