A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis

Vanni, Francesca; Lopresti, Ludovica; Zurli, Vanessa; Kabanova, Anna; Cattaneo, Francesca; Sicuranza, Anna; Gozzetti, Alessandro; Gemma, Sandra; Zisterer, Daniela M.; Bocchia, Monica; Campiani, Giuseppe; Baldari, Cosima T.; Butini, Stefania; Ulivieri, Cristina

doi:10.1016/j.phrs.2021.105965

Cited by 2 publications

(1 citation statement)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The C13 carbon signal appeared at (160.5)ppm belonging to the carbonyl group, and the C14 carbon signal appeared at (151.78)ppm. The sign of the as in Figure -5.Oxazepines ring MA (3)(4)(5)(6) were prepared from the reaction of Schiff bases MA (1,2) with maleic anhydride or phthalic anhydride by cyclization addition reaction (2+5) profits conferring to the following mechanics to form a heptagon (22), in a reflux condition for (6-7) hours using dry dioxane as a solvent. Scheme-3 displays general mechanism: Scheme 3.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and cytotoxicity evaluation of pyrazole compounds bearing oxazepine core against breast cancer cells

Azzawi

Hussein

2022

ijhs

View full text Add to dashboard Cite

The research included the preparation of two Schiff bases MA1,2 starting from1-methyl-pyrazole-4-carbaldehyde with 4-chloroaniline or 4-amino antipyrine in equal moles in the presence of glacial acetic acid. Then xazepane rings MA (3-6) were prepared from MA1,2 with phthalic anhydride or maleic anhydride. The prepared chemical formulas were confirmed using FTIR, 1HNMR, and 13CNMR spectroscopy. The toxicity activity of the compound MA2 against breast cancer MDA and REF cells was tested at seven concentrations (400, 200, 100, 50, 25, 12.5, 6.25) ml/ µg. The study also showed the lowest inhibition rate for MDA cancer line cells at 6.25 µg/ml by (4%) and the highest inhibition rate at 400 µg/ml by 77%, and the study showed the compound with the highest toxicity in healthy cells (64%-80%).

show abstract