A novel chondroitin sulfate decorated nano platinum for the treatment of osteoarthritis

Yin, Xiaoli; Wang, Lin-liang; Chu, Xiu-Cheng

doi:10.1016/j.msec.2017.04.028

Cited by 14 publications

(6 citation statements)

References 12 publications

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“… 91 Furthermore, the biodegradability of many green nanomaterials ensures their eventual natural decomposition, reducing the potential for long-term environmental pollution—a key consideration when contemplating the disposal of medical devices and implants. 92 …”

Section: The Applications Of Bioprinting Dds In Oa Therapymentioning

confidence: 99%

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Yang,

Liu,

Zhang

et al. 2023

IJN

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Bioprinting is an advanced technology that allows for the precise placement of cells and biomaterials in a controlled manner, making significant contributions in regenerative medicine. Notably, bioprinting-enabled biomaterials have found extensive application as drug delivery systems (DDS) in the treatment of osteoarthritis (OA). Despite the widespread utilization of these biomaterials, there has been limited comprehensive research summarizing the recent advances in this area. Therefore, this review aims to explore the noteworthy developments and challenges associated with utilizing bioprinting-enabled biomaterials as effective DDS for the treatment of OA. To begin, we provide an overview of the complex pathophysiology of OA, highlighting the shortcomings of current treatment modalities. Following this, we conduct a detailed examination of various bioprinting technologies and discuss the wide range of biomaterials employed in DDS applications for OA therapy. Finally, by placing emphasis on their transformative potential, we discuss the incorporation of crucial cellular components such as chondrocytes and mesenchymal stem cells into bioprinted constructs, which play a pivotal role in promoting tissue regeneration and repair.

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Section: The Applications Of Bioprinting Dds In Oa Therapymentioning

confidence: 99%

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Yang,

Liu,

Zhang

et al. 2023

IJN

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“…Although the oral drug delivery has been commercialized, there is still challenge in securing instability of delivery system to achieve its efficacy. As the moiety of nanoparticles, chondroitin sulfate displays the potential to increase delivery efficiency in joints while without leading to toxicity [122,123]. The hydrophilicity property of chondroitin sulfate-based nanoparticles increases water solubility of hydrophobic drugs, prolongs articular cavity retention, and promotes cartilage targeting [122,123].…”

Section: Chondroitin Sulfatementioning

confidence: 99%

Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Dai

Guo

et al. 2021

Nano-Micro Lett.

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Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge medical and socioeconomic burdens. Intra-articular administration of agents is clinically used for pain management. However, the effectiveness is inapparent caused by the rapid clearance of agents. To overcome this issue, nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic agents. Given the therapeutic programs are inseparable from pathological progress of osteoarthritis, an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders. In this review, we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release. Then, we review the interactions of nanoparticles with cartilage microenvironment and the rational design. Furthermore, we highlight advances in the therapeutic schemes according to the pathology signals. Finally, armed with an updated understanding of the pathological mechanisms, we place an emphasis on the development of “smart” bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals. We anticipate that the exploration of nanoparticles by balancing the efficacy, safety, and complexity will lay down a solid foundation tangible for clinical translation.

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“…In vitro cytotoxicity data showed the biocompatibility of PtNPs against osteoarthritis chondrocytes, which conrmed that the obtained nanoparticles may potentiate the treatment of osteoarthritis. 16…”

Section: Decorated Chondroitin Sulfate Nanoplatinum For the Treatmentmentioning

confidence: 99%

Chondroitin: a natural biomarker with immense biomedical applications

Pal

Saha²

2019

RSC Adv.

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A novel chondroitin sulfate decorated nano platinum for the treatment of osteoarthritis

Cited by 14 publications

References 12 publications

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Chondroitin: a natural biomarker with immense biomedical applications

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